Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Hira Lal Goel"'
Autor:
Dimpi Mukhopadhyay, Hira Lal Goel, Choua Xiong, Shivam Goel, Ayush Kumar, Rui Li, Lihua Julie Zhu, Jennifer L. Clark, Michael A. Brehm, Arthur M. Mercurio
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113347- (2023)
Summary: Understanding the cell biological mechanisms that enable tumor cells to persist after therapy is necessary to improve the treatment of recurrent disease. Here, we demonstrate that transient receptor potential channel 6 (TRPC6), a channel tha
Externí odkaz:
https://doaj.org/article/7444b6fcbf5240869afc18f3d3cac501
Autor:
Hira Lal Goel, Bryan Pursell, Leonard D. Shultz, Dale L. Greiner, Rolf A. Brekken, Craig W. Vander Kooi, Arthur M. Mercurio
Publikováno v:
Cell Reports, Vol 14, Iss 9, Pp 2193-2208 (2016)
Autocrine VEGF signaling is critical for sustaining prostate and other cancer stem cells (CSCs), and it is a potential therapeutic target, but we observed that CSCs isolated from prostate tumors are resistant to anti-VEGF (bevacizumab) and anti-VEGFR
Externí odkaz:
https://doaj.org/article/8c17537e827f446195f5c1b49e43bb2d
Autor:
Hira Lal Goel, Tatiana Gritsko, Bryan Pursell, Cheng Chang, Leonard D. Shultz, Dale L. Greiner, Jens Henrik Norum, Rune Toftgard, Leslie M. Shaw, Arthur M. Mercurio
Publikováno v:
Cell Reports, Vol 7, Iss 3, Pp 747-761 (2014)
Although the α6β1 integrin has been implicated in the function of breast and other cancer stem cells (CSCs), little is known about its regulation and relationship to mechanisms involved in the genesis of CSCs. We report that a CD44high/CD24low popu
Externí odkaz:
https://doaj.org/article/4e1a162adbeb445b9041895eb6512251
Autor:
Hira Lal Goel, Bryan Pursell, Cheng Chang, Leslie M. Shaw, Junhao Mao, Karl Simin, Prashant Kumar, Craig W. Vander Kooi, Leonard D. Shultz, Dale L. Greiner, Jens Henrik Norum, Rune Toftgard, Charlotte Kuperwasser, Arthur M. Mercurio
Publikováno v:
EMBO Molecular Medicine, Vol 5, Iss 4, Pp 488-508 (2013)
Abstract The characterization of cells with tumour initiating potential is significant for advancing our understanding of cancer and improving therapy. Aggressive, triple‐negative breast cancers (TNBCs) are enriched for tumour‐initiating cells (T
Externí odkaz:
https://doaj.org/article/5c5c12d73f9b40ce892c14ae1500217b
Autor:
Thomas J. FitzGerald, Lucia R. Languino, Dario C. Altieri, Hira Lal Goel, Michael R. Alavian, Mai Vue, Jiayi Huang, Tao Wang
cRGD PC-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d62a53e16526927344ec26ccaadca1
https://doi.org/10.1158/1541-7786.22514479.v1
https://doi.org/10.1158/1541-7786.22514479.v1
Autor:
Arthur M. Mercurio, Stephen R. Plymate, Roger J. Davis, Robert L. Vessella, Peter S. Nelson, Ilsa M. Coleman, Pradip Roy-Burman, Helty Adisetiyo, Chung-Cheng Hsieh, Hualin Simon Xi, Stephen Lyle, Irwin Leav, Bryan Pursell, Cheng Chang, Hira Lal Goel
PDF file - 819K, List of primer sequences for semi-quantitative and quantitative PCR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf73393db3013b6384478cc00eef3b5c
https://doi.org/10.1158/2159-8290.22528323
https://doi.org/10.1158/2159-8290.22528323
Autor:
Arthur M. Mercurio, Stephen R. Plymate, Roger J. Davis, Robert L. Vessella, Peter S. Nelson, Ilsa M. Coleman, Pradip Roy-Burman, Helty Adisetiyo, Chung-Cheng Hsieh, Hualin Simon Xi, Stephen Lyle, Irwin Leav, Bryan Pursell, Cheng Chang, Hira Lal Goel
PDF file - 504K, Response of xenografts of human prostate cancer specimens to IGF-1R inhibition as a function of NRP2 expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295edcca33a65a6ce1108ff9fdef3db9
https://doi.org/10.1158/2159-8290.22528326.v1
https://doi.org/10.1158/2159-8290.22528326.v1
Autor:
Arthur M. Mercurio, Stephen R. Plymate, Roger J. Davis, Robert L. Vessella, Peter S. Nelson, Ilsa M. Coleman, Pradip Roy-Burman, Helty Adisetiyo, Chung-Cheng Hsieh, Hualin Simon Xi, Stephen Lyle, Irwin Leav, Bryan Pursell, Cheng Chang, Hira Lal Goel
PDF file - 454K, Role of JNK/c-Jun in regulating NRP2 expression in prostate carcinoma cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3efccae0f6307b050a11fd5c4d33e409
https://doi.org/10.1158/2159-8290.22528335
https://doi.org/10.1158/2159-8290.22528335
Autor:
Arthur M. Mercurio, Stephen R. Plymate, Roger J. Davis, Robert L. Vessella, Peter S. Nelson, Ilsa M. Coleman, Pradip Roy-Burman, Helty Adisetiyo, Chung-Cheng Hsieh, Hualin Simon Xi, Stephen Lyle, Irwin Leav, Bryan Pursell, Cheng Chang, Hira Lal Goel
PDF file - 1.8MB, Evaluation of insulin signaling in prostate tumors and cell lines as a function of NRP2 expression and role of VEGF in regulation of Bmi-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::234d2f155ca4325ac0e5289d5af835d8
https://doi.org/10.1158/2159-8290.22528329.v1
https://doi.org/10.1158/2159-8290.22528329.v1
Autor:
Arthur M. Mercurio, Stephen R. Plymate, Roger J. Davis, Robert L. Vessella, Peter S. Nelson, Ilsa M. Coleman, Pradip Roy-Burman, Helty Adisetiyo, Chung-Cheng Hsieh, Hualin Simon Xi, Stephen Lyle, Irwin Leav, Bryan Pursell, Cheng Chang, Hira Lal Goel
We show that the VEGF receptor neuropilin-2 (NRP2) is associated with high-grade, PTEN-null prostate cancer and that its expression in tumor cells is induced by PTEN loss as a consequence of c-Jun activation. VEGF/NRP2 signaling represses insulin-lik
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0392679cb4149d201f91278b922d2110
https://doi.org/10.1158/2159-8290.c.6545694
https://doi.org/10.1158/2159-8290.c.6545694