Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Hira L, Nakhasi"'
Autor:
Kumar Avishek, Mirza A. Beg, Kavita Vats, Avinash Kumar Singh, Ranadhir Dey, Kamaleshwar P. Singh, Rajesh Kumar Singh, Sreenivas Gannavaram, V. Ramesh, Mohmad Sadik A. Mulla, Upendra Bhatnagar, Sanjay Singh, Hira L. Nakhasi, Poonam Salotra, Angamuthu Selvapandiyan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Centrin1 gene deleted Leishmania donovani parasite (LdCen1 −/− ) was developed and extensively tested experimentally as an intracellular stage-specific attenuated and immunoprotective live parasite vaccine candidate ex vivo using human P
Externí odkaz:
https://doaj.org/article/73ff0db110c94aabb0c13d03ddf5653b
Autor:
Ranadhir Dey, Jalal Alshaweesh, Kamaleshwar P. Singh, Patrick Lypaczewski, Subir Karmakar, Laura Klenow, Kayla Paulini, Swarnendu Kaviraj, Shaden Kamhawi, Jesus G. Valenzuela, Sanjay Singh, Shinjiro Hamano, Abhay R. Satoskar, Sreenivas Gannavaram, Hira L. Nakhasi, Greg Matlashewski
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract The leishmanin skin test was used for almost a century to detect exposure and immunity to Leishmania, the causative agent of leishmaniasis, a major neglected tropical disease. Due to a lack of antigen used for the intradermal injection, the
Externí odkaz:
https://doaj.org/article/11c3719514794468adb0c66ddc329d73
Autor:
Greta Volpedo, Timur Oljuskin, Blake Cox, Yulian Mercado, Candice Askwith, Nazli Azodi, Matthew Bernier, Hira L. Nakhasi, Sreenivas Gannavaram, Abhay R. Satoskar
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108502- (2023)
Summary: Cutaneous leishmaniasis (CL) is characterized by extensive skin lesions, which are usually painless despite being associated with extensive inflammation. The molecular mechanisms responsible for this analgesia have not been identified. Throu
Externí odkaz:
https://doaj.org/article/4bf860590ede4681a76816146cf835c2
Autor:
Francys Avendaño-Rangel, Gabriela Agra-Duarte, Pedro B. Borba, Valdomiro Moitinho, Leslye T. Avila, Larissa O. da Silva, Sayonara M. Viana, Rohit Sharma, Sreenivas Gannavaram, Hira L. Nakhasi, Camila I. de Oliveira
Publikováno v:
Vaccines, Vol 12, Iss 3, p 310 (2024)
Immunization with various Leishmania species lacking centrin induces robust immunity against a homologous and heterologous virulent challenge, making centrin mutants a putative candidate for a leishmaniasis vaccine. Centrin is a calcium-binding cytos
Externí odkaz:
https://doaj.org/article/b4adae6e682d4013afe28c0f38a39e1e
Autor:
Konstantinos Karagiannis, Sreenivas Gannavaram, Chaitenya Verma, Thalia Pacheco-Fernandez, Parna Bhattacharya, Hira L. Nakhasi, Abhay R. Satoskar
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113097- (2023)
Summary: Although phagocytic cells are documented targets of Leishmania parasites, it is unclear whether other cell types can be infected. Here, we use unbiased single-cell RNA sequencing (scRNA-seq) to simultaneously analyze host cell and Leishmania
Externí odkaz:
https://doaj.org/article/9b1ee9ec4bf04ba89c4a87f600095aeb
Autor:
Subir Karmakar, Greta Volpedo, Wen-Wei Zhang, Patrick Lypaczewski, Nevien Ismail, Fabiano Oliveira, James Oristian, Claudio Meneses, Sreenivas Gannavaram, Shaden Kamhawi, Shinjiro Hamano, Jesus G. Valenzuela, Greg Matlashewski, Abhay R. Satoskar, Ranadhir Dey, Hira L. Nakhasi
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-9 (2022)
Abstract Leishmaniasis is one of the top neglected tropical diseases with significant morbidity and mortality in low and middle-income countries (LMIC). However, this disease is also spreading in the developed world. Currently, there is a lack of eff
Externí odkaz:
https://doaj.org/article/26413e213d76441788ba0d0d2b589f6a
Autor:
Pravin R. Kaldhone, Nazli Azodi, Hannah L. Markle, Neetu Dahiya, Caitlin Stewart, John Anderson, Scott MacGregor, Michelle Maclean, Hira L. Nakhasi, Sreenivas Gannavaram, Chintamani Atreya
Publikováno v:
Microorganisms, Vol 12, Iss 2, p 280 (2024)
Violet–blue light of 405 nm in the visible spectrum at a dose of 270 J/cm2 alone has been shown to be an effective microbicidal tool for inactivating several bacteria, HIV-1, and Trypanosoma cruzi in ex vivo plasma and platelets. Unlike chemical- a
Externí odkaz:
https://doaj.org/article/b2a5ea4b3b474c2e9fa0fff8c3b3fd0b
Autor:
Greta Volpedo, Thalia Pacheco-Fernandez, Erin A. Holcomb, Wen-Wei Zhang, Patrick Lypaczewski, Blake Cox, Rebecca Fultz, Chelsea Mishan, Chaitenya Verma, Ryan H. Huston, Abigail R. Wharton, Ranadhir Dey, Subir Karmakar, Steve Oghumu, Shinjiro Hamano, Sreenivas Gannavaram, Hira L. Nakhasi, Greg Matlashewski, Abhay R. Satoskar
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-14 (2022)
Abstract Leishmaniasis is a neglected protozoan disease affecting over 12 million people globally with no approved vaccines for human use. New World cutaneous leishmaniasis (CL) caused by L. mexicana is characterized by the development of chronic non
Externí odkaz:
https://doaj.org/article/978c751f55954a559bd01abf5ad9b254
Autor:
Subir Karmakar, Nevien Ismail, Fabiano Oliveira, James Oristian, Wen Wei Zhang, Swarnendu Kaviraj, Kamaleshwar P. Singh, Abhishek Mondal, Sushmita Das, Krishna Pandey, Parna Bhattacharya, Greta Volpedo, Sreenivas Gannavaram, Monika Satoskar, Sanika Satoskar, Rajiv M. Sastry, Timur Oljuskin, Telly Sepahpour, Claudio Meneses, Shinjiro Hamano, Pradeep Das, Greg Matlashewski, Sanjay Singh, Shaden Kamhawi, Ranadhir Dey, Jesus G. Valenzuela, Abhay Satoskar, Hira L. Nakhasi
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Karmakar et al produced a dermotropic, live attenuated centrin gene-deleted Leishmania major (LmCen −/− ) vaccine against Visceral Leishmaniasis (VL). They demonstrated in hamsters that a single intradermal injection confers robust and durable pr
Externí odkaz:
https://doaj.org/article/b17a11a8c0a341a0abe1473e6b12a4ae
Autor:
Parna Bhattacharya, Sreenivas Gannavaram, Nevien Ismail, Ankit Saxena, Pradeep K. Dagur, Adovi Akue, Mark KuKuruga, Hira L. Nakhasi
Publikováno v:
Pathogens, Vol 12, Iss 4, p 534 (2023)
No human vaccine is available for visceral leishmaniasis (VL). Live attenuated centrin gene-deleted L. donovani (LdCen−/−) parasite vaccine has been shown to induce robust innate immunity and provide protection in animal models. Toll-like recepto
Externí odkaz:
https://doaj.org/article/ce954f59d47649aeac64fc072e4e623b