Zobrazeno 1 - 10
of 435
pro vyhledávání: '"Hipsc cms"'
Autor:
Linda Starnes, Andrew Hall, Damla Etal, Anna-Lina Cavallo, Piotr Grabowski, John Gallon, Michelle Kha, Ryan Hicks, Amy Pointon
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
Creation of disease models utilizing hiPSCs in combination with CRISPR/Cas9 gene editing enable mechanistic insights into differential pharmacological responses. This allows translation of efficacy and safety findings from a healthy to a diseased sta
Externí odkaz:
https://doaj.org/article/e132b887164947bbaa01aa31e0c55474
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-17 (2024)
Abstract Background Acute cardiac injury caused by coronavirus disease 2019 (COVID-19) increases mortality. Acute cardiac injury caused by COVID-19 requires understanding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) directly infec
Externí odkaz:
https://doaj.org/article/a8790900c1754606bf27dec3246eb193
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 17, p 9627 (2024)
Acute myocardial infarction (MI) is a sudden, severe cardiac ischemic event that results in the death of up to one billion cardiomyocytes (CMs) and subsequent decrease in cardiac function. Engineered cardiac tissues (ECTs) are a promising approach to
Externí odkaz:
https://doaj.org/article/737910db080242d7beff07b2eb519fed
Autor:
Changzhu Li, Yang Zhang, Jingling Shen, Hairong Bao, Yue Zhao, Desheng Li, Sijia Li, Yining Liu, Jiming Yang, Zhiwen Zhou, Kangyi Gao, Lexin Zhao, Yao Pei, Yanjie Lu, Zhenwei Pan, Benzhi Cai
Publikováno v:
Advanced Science, Vol 11, Iss 11, Pp n/a-n/a (2024)
Abstract Cardiomyocyte maturation is the final stage of heart development, and abnormal cardiomyocyte maturation will lead to serious heart diseases. CXXC zinc finger protein 1 (Cfp1), a key epigenetic factor in multi‐lineage cell development, rema
Externí odkaz:
https://doaj.org/article/0a81858492eb4ffe99491a74c358ee28
Publikováno v:
Genes and Diseases, Vol 10, Iss 5, Pp 2151-2166 (2023)
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have attracted attention in the field of regenerative medicine due to their potential ability to repair damaged hearts. However, the immature phenotype of these cells limits their
Externí odkaz:
https://doaj.org/article/ed52fc8c95c34a11931994ba9da70c4e
Autor:
Huiwen Liu, Li Wang, Hao Xu, Bin Tan, Qin Yi, Hongrong Deng, Yunxia Chen, Bolin He, Jie Tian, Jing Zhu
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-20 (2023)
Abstract Background Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are seed cells that can be used for alternative treatment of myocardial damage. However, their immaturity limits their clinical application. Mitochondrial deve
Externí odkaz:
https://doaj.org/article/f50fca79db404ec5ab27ae3e6935d67a
Autor:
Giovanna Nasilli, Arie O. Verkerk, Molly O’Reilly, Loukia Yiangou, Richard P. Davis, Simona Casini, Carol Ann Remme
Publikováno v:
Biomedicines, Vol 12, Iss 6, p 1212 (2024)
A sodium current (INa) reduction occurs in the setting of many acquired and inherited conditions and is associated with cardiac conduction slowing and increased arrhythmia risks. The sodium channel blocker mexiletine has been shown to restore the tra
Externí odkaz:
https://doaj.org/article/fe7447100f724815a62f685b1a775531
Autor:
Marion Pierre, Mohammed Djemai, Charles-Albert Chapotte-Baldacci, Valérie Pouliot, Jack Puymirat, Mohamed Boutjdir, Mohamed Chahine
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Myotonic dystrophy type 1 (DM1) is a genetic disorder that causes muscle weakness and myotonia. In DM1 patients, cardiac electrical manifestations include conduction defects and atrial fibrillation. DM1 results in the expansion of a CTG transcribed i
Externí odkaz:
https://doaj.org/article/0d13b5b54edd48f48866811e646083ee
Autor:
Bozhidar Baltov, Stanislav Beyl, Igor Baburin, Jakob Reinhardt, Phillip Szkokan, Aleksandra Garifulina, Eugen Timin, Udo Kraushaar, Olivier Potterat, Matthias Hamburger, Philipp Kügler, Steffen Hering
Publikováno v:
Toxicology Reports, Vol 10, Iss , Pp 589-599 (2023)
Guidelines for preclinical drug development reduce the occurrence of arrhythmia-related side effects. Besides ample evidence for the presence of arrhythmogenic substances in plants, there is no consensus on a research strategy for the evaluation of p
Externí odkaz:
https://doaj.org/article/fda309defa0a4cfd8025cc81e3d736a8
Autor:
C. Altrocchi, K. Van Ammel, M. Steemans, M. Kreir, F. Tekle, A. Teisman, D. J. Gallacher, H. R. Lu
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Cardiotoxicity is one of the leading causes of compound attrition during drug development. Most in vitro screening platforms aim at detecting acute cardio-electrophysiological changes and drug-induced chronic functional alterations are
Externí odkaz:
https://doaj.org/article/d44739f6216b4c15814380bf7c3a9f7c