Zobrazeno 1 - 10
of 888
pro vyhledávání: '"Hippo/YAP"'
Autor:
Xiaowen Zhu, Pengxia Zhang
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background Recent evidence has demonstrated the vital roles of circular RNAs (circRNAs) in the progression of colorectal cancer (CRC); however, their functions and mechanisms in CRC need to be further explored. This study aimed to uncover th
Externí odkaz:
https://doaj.org/article/1f324f3bc2fb48db959e1be0e5f363b9
Autor:
Ye Fan, He‐Qin Zou
Publikováno v:
Kaohsiung Journal of Medical Sciences, Vol 40, Iss 10, Pp 890-902 (2024)
Abstract Glioma, a common malignancy, is characterized by high morbidity and mortality. Promoting ferroptosis can delay tumor progression. Here, we aimed to explore the underlying mechanism of ferroptosis in glioma. In vitro and in vivo experiments w
Externí odkaz:
https://doaj.org/article/1a5275400a1346bf98151c0375b5aa35
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The Hippo-Yes-associated protein (Hippo-YAP) signaling pathway, a conserved pathway that regulates organ size, participates in tumor progression. However, there are few comprehensive analyses of tumor prognosis and immunity. In the present s
Externí odkaz:
https://doaj.org/article/bc88c607fe234eb8b0a1484ee48b7e05
Autor:
Tong-Mei Zhang, Mai-Ning Jiao, Kun Yang, Hua-Lun Wang, Chang-Song Zhang, Shi-Hua Wang, Guan-Meng Zhang, He-Jing Miao, Jun Shen, Ying-Bin Yan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract To explore the role of YAP, a key effector of the Hippo pathway, in temporomandibular joint (TMJ) ankylosis. The temporal and spatial expression of YAP was detected via immunohistochemistry and multiplex immunohistochemistry on postoperative
Externí odkaz:
https://doaj.org/article/22b99e6ecfab4a8091cba4955c7d5fd7
Publikováno v:
Translational Oncology, Vol 49, Iss , Pp 102076- (2024)
Objectives: Triple-negative breast cancer (TNBC) is the deadliest subtype of breast cancer (BC). Tumor-derived extracellular vesicles (EVs) trigger tumor progression by promoting M2 polarization. Some lncRNAs can be encapsulated into EVs for intercel
Externí odkaz:
https://doaj.org/article/51bb4c896c06406893fbdbee72064193
Autor:
Li Xie, Hui Chen, Li Zhang, Yue Ma, Yuan Zhou, Yong-Yu Yang, Chang Liu, Yu-Li Wang, Ya-Jun Yan, Jia Ding, Xiao Teng, Qiang Yang, Xiu-Ping Liu, Jian Wu
Publikováno v:
Clinical and Molecular Hepatology, Vol 30, Iss 2, Pp 206-224 (2024)
Background/Aims Cholestatic liver diseases including primary biliary cholangitis (PBC) are associated with active hepatic fibrogenesis, which ultimately progresses to cirrhosis. Activated hepatic stellate cells (HSCs) are the main fibrogenic effector
Externí odkaz:
https://doaj.org/article/105246d534294e329a2787001f048cec
Autor:
Cho-Long Kim, Su-Bin Lim, Dong Hyun Kim, Ye Eun Sim, Li-Jung Kang, Su Jung Park, Hyungwoo Kim, Tae Hoon Roh, Jung-Soon Mo, Han-Sol Jeong
Publikováno v:
Translational Oncology, Vol 46, Iss , Pp 101971- (2024)
Cholangiocarcinoma (CCA) is a devastating malignancy characterized by aggressive tumor growth and limited treatment options. Dysregulation of the Hippo signaling pathway and its downstream effector, Yes-associated protein (YAP), has been implicated i
Externí odkaz:
https://doaj.org/article/bf71932560d04652b65216cc8f13714d
Publikováno v:
Molecular Medicine, Vol 29, Iss 1, Pp 1-17 (2023)
Abstract Background Shenqi Compound (SQC) has been used in clinic for several decades in the prevention and treatment of diabetes and its complications. But this is merely a heritage of experience. The primary aim of this study is to scientifically v
Externí odkaz:
https://doaj.org/article/fd1cd3bef2c74822a09133df25e1d9e0
Autor:
Li Zhang, Yong‐Yu Yang, Li Xie, Yuan Zhou, Zhenxing Zhong, Jia Ding, Zhong‐Hua Wang, Yu‐Li Wang, Xiu‐Ping Liu, Fa‐Xing Yu, Jian Wu
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 3, Pp n/a-n/a (2024)
Abstract Background and aims Liver regeneration retardation post partial hepatectomy (PH) is a common clinical problem after liver transplantation. Identification of key regulators in liver regeneration post PH may be beneficial for clinically improv
Externí odkaz:
https://doaj.org/article/867a9485c7ff4e6aa2d840d24e4f7ae6
Publikováno v:
Cells, Vol 13, Iss 16, p 1342 (2024)
From birth to adulthood, the mammalian heart grows primarily through increasing cardiomyocyte (CM) size, which is known as maturational hypertrophic growth. The Hippo-YAP signaling pathway is well known for regulating heart development and regenerati
Externí odkaz:
https://doaj.org/article/ca044dfa2e164160ab1bedc2fc8cce88