Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders

Autor: Ramírez, Sara, Haddad-Tóvolli, Roberta, Radosevic, Marija, Toledo, Miriam, Pané, Adriana, Alcolea, Daniel, Ribas, Vicent, Milà-Guasch, Maria, Pozo, Macarena, Obri, Arnaud, Eyre, Elena, Gómez-Valadés, Alicia G., Chivite, Iñigo, Van Eeckhout, Tomas, Zalachoras, Ioannis, Altirriba, Jordi, Bauder, Corinna, Imbernón, Mónica, Garrabou, Gloria, Garcia-Ruiz, Carmen, Nogueiras, Rubén, Soto, David, Gasull, Xavier, Sandi, Carmen, Brüning, Jens C., Fortea, Juan, Jiménez, Amanda, Fernández-Checa, José C., Claret, Marc, Universitat Autònoma de Barcelona

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Cell Metabolism
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname

Obesity and type 2 diabetes are associated with cognitive dysfunction. Because the hypothalamus is implicated in energy balance control and memory disorders, we hypothesized that specific neurons in this brain region are at the interface of metabolis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce1fdfcd2f01d390f531a67b900dc20
http://hdl.handle.net/2445/183707

Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis

Autor: Arnaud Obri, Angela R. Garcia-Rendueles, Giuseppe D'Agostino, Bence Rácz, Iñigo Chivite, Marc Schneeberger, Mehdi Boutagouga Boudjadja, Maria Milà-Guasch, Pau Gama-Perez, Ramon Gomis, Roberta Haddad-Tóvolli, Antonio Zorzano, Maria Teresa Alonso, Jordi Altirriba, Jonathan Rojo-Ruiz, Luis Varela, Tamas L. Horvath, Clara V. Alvarez, Monica Imbernon, Pablo M. Garcia-Roves, Alicia G. Gómez-Valadés, Marc Claret, Elena Eyre, Sara Ramírez, Rubén Nogueiras, Macarena Pozo

Publikováno v: Cell Metabolism
Dipòsit Digital de la UB
Universidad de Barcelona
Digital.CSIC. Repositorio Institucional del CSIC
instname
Gómez-valadés, A G, Pozo, M, Varela, L, Boudjadja, M B, Ramírez, S, Chivite, I, Eyre, E, Haddad-tóvolli, R, Obri, A, Milà-guasch, M, Altirriba, J, Schneeberger, M, Imbernón, M, Garcia-rendueles, A R, Gama-perez, P, Rojo-ruiz, J, Rácz, B, Alonso, M T, Gomis, R, Zorzano, A, D’agostino, G, Alvarez, C V, Nogueiras, R, Garcia-roves, P M, Horvath, T L & Claret, M 2021, ' Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis ', Cell Metabolism, vol. 33, no. 9, pp. 1820-1835.e9 . https://doi.org/10.1016/j.cmet.2021.07.008

Summary Appropriate cristae remodeling is a determinant of mitochondrial function and bioenergetics and thus represents a crucial process for cellular metabolic adaptations. Here, we show that mitochondrial cristae architecture and expression of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb60a2466d25edb8839ba2edaabee22
http://hdl.handle.net/2445/180330

New Insights of SF1 Neurons in Hypothalamic Regulation of Obesity and Diabetes

Autor: Rosalía Rodríguez-Rodríguez, Anna Fosch, Núria Casals, Sebastián Zagmutt

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 6186, p 6186 (2021)

Despite the substantial role played by the hypothalamus in the regulation of energy balance and glucose homeostasis, the exact mechanisms and neuronal circuits underlying this regulation remain poorly understood. In the last 15 years, investigations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e5d0a09d50de30da01c5ad6b5932e63
http://europepmc.org/articles/PMC8229730

Melanin-Concentrating Hormone acts through hypothalamic kappa opioid system and p70S6K to stimulate acute food intake

Autor: Miguel López, Roger A.H. Adan, Amparo Romero-Picó, Estrella Sanchez-Rebordelo, David González-Touceda, Monica Imbernon, Rubén Nogueiras, Clemence Blouet, Johan Fernø, Roberto Cabrera, Rafael Maldonado, Carlos Dieguez, Ana Senra, Cintia Folgueira, Margriet A. van Gestel

Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
instname
Neuropharmacology, 130, 62. Elsevier Limited

Melanin-Concentrating Hormone (MCH) is one of the most relevant orexigenic factors specifically located in the lateral hypothalamic area (LHA), with its physiological relevance demonstrated in studies using several genetically manipulated mice models

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6011dfba92c85604b4248a928842d2e1
https://doi.org/10.1016/j.neuropharm.2017.11.040

Hypothalamic Control of Systemic Glucose Homeostasis: The Pancreas Connection

Autor: Macarena Pozo, Marc Claret

Publikováno v: Trends in Endocrinology & Metabolism
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona

Maintenance of glucose homeostasis is mandatory for organismal survival. It is accomplished by complex and coordinated interplay between glucose detection mechanisms and multiple effector systems. The brain, in particular homeostatic regions such as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72e4b4466ad79d5ba0bed0be364ff460
https://pubmed.ncbi.nlm.nih.gov/29866501