Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01

Autor: Weiner, J., Suwalski, P., Holtgrewe, M., Rakitko, A., Thibeault, C., Müller, M., Patriki, D., Quedenau, C., Krüger, U., Ilinsky, V., Popov, I., Balnis, J., Jaitovich, A., Helbig, E.T., Lippert, L.J., Stubbemann, P., Real, L.M., Macías, J., Pineda, J.A., Fernandez-Fuertes, M., Wang, X., Karadeniz, Z., Saccomanno, J., Doehn, J.M., Hübner, R.H., Hinzmann, B., Salvo, M., Blueher, A., Siemann, S., Jurisic, S., Beer, J.H., Rutishauser, J., Wiggli, B., Schmid, H., Danninger, K., Binder, R., Corman, V.M., Mühlemann, B., Arjun Arkal, R., Fragiadakis, G.K., Mick, E., Calfee, C.S., Erle, D.J., Hendrickson, C.M., Kangelaris, K.N., Krummel, M.F., Woodruff, P.G., Langelier, C.R., Venkataramani, U., García, F., Zyla, J., Drosten, C., Braun, A., Jones, T.C., Suttorp, N., Witzenrath, M., Hippenstiel, S., Zemojtel, T., Skurk, C., Wolfgang, P., Borodina, T., Ripke, S., Sander, L.E., Beule, D., Landmesser, U., Guettouche, T., Kurth, F., Heidecker, B.

BACKGROUND: Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, there has been increasing urgency to identify pathophysiological characteristics leading to severe clinical course in patients infected with severe acute respiratory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=mdc______med::b35f4f8300be7c9234ed733d1e9cca14
http://edoc.mdc-berlin.de/20913/7/20913suppl.zip

Highly multiplexed immune repertoire sequencing links multiple lymphocyte classes with severity of response to COVID-19.

Autor: Dannebaum R; Roche Sequencing Solutions Pleasanton, CA 94588, United States., Suwalski P; Department of Cardiology, Charité Universitätsmedizin Berlin, Berlin, DE 10117, Germany., Asgharian H; Roche Sequencing Solutions Pleasanton, CA 94588, United States., Du Zhipei G; Roche Sequencing Solutions Pleasanton, CA 94588, United States., Lin H; Roche Sequencing Solutions Pleasanton, CA 94588, United States., Weiner J; Core Unit Bioinformatics Berlin, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, DE 10178, Germany., Holtgrewe M; Core Unit Bioinformatics Berlin, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, DE 10178, Germany., Thibeault C; Department of Infectious Diseases and Respiratory Medicine, Charité Universitätsmedizin Berlin, DE 12203, Germany., Müller M; Department of Cardiology, Charité Universitätsmedizin Berlin, Berlin, DE 10117, Germany., Wang X; Department of Cardiology, Charité Universitätsmedizin Berlin, Berlin, DE 10117, Germany., Karadeniz Z; Department of Cardiology, Charité Universitätsmedizin Berlin, Berlin, DE 10117, Germany., Saccomanno J; Department of Infectious Diseases and Respiratory Medicine, Charité Universitätsmedizin Berlin, DE 12203, Germany., Doehn JM; Department of Infectious Diseases and Respiratory Medicine, Charité Universitätsmedizin Berlin, DE 12203, Germany., Hübner RH; Department of Infectious Diseases and Respiratory Medicine, Charité Universitätsmedizin Berlin, DE 12203, Germany., Hinzmann B; Signature Diagnostics GmbH, DE 14473, Germany., Blüher A; Signature Diagnostics GmbH, DE 14473, Germany., Siemann S; Signature Diagnostics GmbH, DE 14473, Germany., Telman D; Roche Sequencing Solutions Pleasanton, CA 94588, United States., Suttorp N; Department of Infectious Diseases and Respiratory Medicine, Charité Universitätsmedizin Berlin, DE 12203, Germany., Witzenrath M; Department of Infectious Diseases and Respiratory Medicine, Charité Universitätsmedizin Berlin, DE 12203, Germany., Hippenstiel S; Department of Infectious Diseases and Respiratory Medicine, Charité Universitätsmedizin Berlin, DE 12203, Germany., Skurk C; Department of Cardiology, Charité Universitätsmedizin Berlin, Berlin, DE 10117, Germany., Poller W; Department of Cardiology, Charité Universitätsmedizin Berlin, Berlin, DE 10117, Germany., Sander LE; Department of Infectious Diseases and Respiratory Medicine, Charité Universitätsmedizin Berlin, DE 12203, Germany., Beule D; Core Unit Bioinformatics Berlin, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, DE 10178, Germany., Kurth F; Department of Infectious Diseases and Respiratory Medicine, Charité Universitätsmedizin Berlin, DE 12203, Germany., Guettouche T; Roche Sequencing Solutions Pleasanton, CA 94588, United States., Landmesser U; Department of Cardiology, Charité Universitätsmedizin Berlin, Berlin, DE 10117, Germany.; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Germany., Berka J; Roche Sequencing Solutions Pleasanton, CA 94588, United States., Luong K; Roche Sequencing Solutions Pleasanton, CA 94588, United States., Rubelt F; Roche Sequencing Solutions Pleasanton, CA 94588, United States., Heidecker B; Department of Cardiology, Charité Universitätsmedizin Berlin, Berlin, DE 10117, Germany.

Publikováno v: EClinicalMedicine [EClinicalMedicine] 2022 Jun; Vol. 48, pp. 101438. Date of Electronic Publication: 2022 May 14.

Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01.

Autor: Weiner J; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Core Unit Bioinformatics Berlin, DE 10178, Germany., Suwalski P; Department of Cardiology, Charite Universitaetsmedizin Berlin, DE 12203, Germany.; Berliner Simulations- und Trainingszentrum, Charite, Berlin, DE 10117, Germany., Holtgrewe M; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Core Unit Genomics Berlin, DE 10178, Germany., Rakitko A; Genotek Ltd., Nastavnicheskii pereulok 17/1, R 105120 Moscow, Russian Federation., Thibeault C; Charite Universitaetsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine Berlin, DE 10117, Germany., Müller M; Department of Cardiology, Charite Universitaetsmedizin Berlin, DE 12203, Germany., Patriki D; Kantonsspital Baden AG, Department of Medicine, Baden, CH 5404, Switzerland., Quedenau C; Max Delbrueck Center for Molecular Medicine Berlin, DE 13125, Germany., Krüger U; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Core Unit Genomics Berlin, DE 10178, Germany., Ilinsky V; Genotek Ltd., Nastavnicheskii pereulok 17/1, R 105120 Moscow, Russian Federation., Popov I; Genotek Ltd., Nastavnicheskii pereulok 17/1, R 105120 Moscow, Russian Federation., Balnis J; Department of Molecular and Cellular Physiology, Albany Medical College, NY, USA., Jaitovich A; Department of Molecular and Cellular Physiology, Albany Medical College, NY, USA., Helbig ET; Charite Universitaetsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine Berlin, DE 10117, Germany., Lippert LJ; Charite Universitaetsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine Berlin, DE 10117, Germany., Stubbemann P; Charite Universitaetsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine Berlin, DE 10117, Germany., Real LM; Unidad Clínica de Enfermedades Infecciosas y Microbiología. Hospital Universitario de Valme, Sevilla, ES 41014, Spain., Macías J; Unidad Clínica de Enfermedades Infecciosas y Microbiología. Hospital Universitario de Valme, Sevilla, ES 41014, Spain., Pineda JA; Unidad Clínica de Enfermedades Infecciosas y Microbiología. Hospital Universitario de Valme, Sevilla, ES 41014, Spain., Fernandez-Fuertes M; Unidad Clínica de Enfermedades Infecciosas y Microbiología. Hospital Universitario de Valme, Sevilla, ES 41014, Spain., Wang X; Department of Cardiology, Charite Universitaetsmedizin Berlin, DE 12203, Germany., Karadeniz Z; Department of Cardiology, Charite Universitaetsmedizin Berlin, DE 12203, Germany., Saccomanno J; Charite Universitaetsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine Berlin, DE 10117, Germany., Doehn JM; Charite Universitaetsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine Berlin, DE 10117, Germany., Hübner RH; Charite Universitaetsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine Berlin, DE 10117, Germany., Hinzmann B; Roche Sequencing Solutions Pleasanton, USA 94588., Salvo M; Roche Sequencing Solutions Pleasanton, USA 94588., Blueher A; Roche Sequencing Solutions Pleasanton, USA 94588., Siemann S; Roche Sequencing Solutions Pleasanton, USA 94588., Jurisic S; Kantonsspital Baden AG, Department of Medicine, Baden, CH 5404, Switzerland., Beer JH; Kantonsspital Baden AG, Department of Medicine, Baden, CH 5404, Switzerland., Rutishauser J; Kantonsspital Baden AG, Department of Medicine, Baden, CH 5404, Switzerland., Wiggli B; Kantonsspital Baden AG, Department of Medicine, Baden, CH 5404, Switzerland., Schmid H; Kantonsspital Baden AG, Department of Medicine, Baden, CH 5404, Switzerland., Danninger K; Department of Cardiology and Intensive Care, Klinikum Wels-Grieskirchen, Wels, Austria., Binder R; Department of Cardiology and Intensive Care, Klinikum Wels-Grieskirchen, Wels, Austria., Corman VM; Charite Universitaetsmedizin Berlin, Institute of Virology Chariteplatz, 1 d-10117, Berlin, DE, 10117, Germany., Mühlemann B; Charite Universitaetsmedizin Berlin, Institute of Virology Chariteplatz, 1 d-10117, Berlin, DE, 10117, Germany., Arjun Arkal R; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; CoLabs, University of California San Francisco, San Francisco, CA, USA.; Department of Pathology, University of California, San Francisco, CA, USA., Fragiadakis GK; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; CoLabs, University of California San Francisco, San Francisco, CA, USA.; Division of Rheumatology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Mick E; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, University of California, San Francisco, CA, USA.; Division of Infectious Diseases, University of California, San Francisco, CA, USA.; Chan Zuckerberg Biohub, San Francisco, CA, USA., Comet C; COMET (COVID-19 Multiphenotyping for Effective Therapies) Consortium members are listed in the Supplementary Appendix 1., Calfee CS; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, University of California, San Francisco, CA, USA., Erle DJ; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; CoLabs, University of California San Francisco, San Francisco, CA, USA.; Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA.; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, University of California, San Francisco, CA, USA.; COMET (COVID-19 Multiphenotyping for Effective Therapies) Consortium members are listed in the Supplementary Appendix 1.; Lung Biology Center, University of California, San Francisco, CA, USA.; Department of Medicine, University of California, San Francisco, CA, USA., Hendrickson CM; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, University of California, San Francisco, CA, USA., Kangelaris KN; Department of Medicine, University of California, San Francisco, CA, USA., Krummel MF; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; Department of Pathology, University of California, San Francisco, CA, USA., Woodruff PG; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, University of California, San Francisco, CA, USA.; Department of Pathology, University of California, San Francisco, CA, USA.; Sandler Asthma Basic Research Center, University of California, San Francisco, CA, USA., Langelier CR; Division of Infectious Diseases, University of California, San Francisco, CA, USA.; Chan Zuckerberg Biohub, San Francisco, CA, USA., Venkataramani U; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; CoLabs, University of California San Francisco, San Francisco, CA, USA., García F; Hospital Universitario Clínico San Cecilio, Instituto de Investigación Ibs. Granada, Spain., Zyla J; Department of Data Science and Engineering, Silesian University of Technology, Gliwice, Poland., Drosten C; Charite Universitaetsmedizin Berlin, Institute of Virology Chariteplatz, 1 d-10117, Berlin, DE, 10117, Germany., Alice B; Charite Universitaetsmedizin Berlin, Dept. of Psychiatry and Psychotherapy Chariteplatz 1 d-10117 Berlin, DE 10117, Germany., Jones TC; Charite Universitaetsmedizin Berlin, Institute of Virology Chariteplatz, 1 d-10117, Berlin, DE, 10117, Germany.; German Center for Infection Research (DZIF), Associated Partner Site, 10117 Berlin, Germany.; Centre for Pathogen Evolution, Department of Zoology, University of Cambridge, Downing St., Cambridge, CB2 3EJ, U.K., Suttorp N; Charite Universitaetsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine Berlin, DE 10117, Germany., Witzenrath M; Charite Universitaetsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine Berlin, DE 10117, Germany., Hippenstiel S; Charite Universitaetsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine Berlin, DE 10117, Germany., Zemojtel T; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Core Unit Genomics Berlin, DE 10178, Germany., Skurk C; Department of Cardiology, Charite Universitaetsmedizin Berlin, DE 12203, Germany., Poller W; Department of Cardiology, Charite Universitaetsmedizin Berlin, DE 12203, Germany., Borodina T; Max Delbrueck Center for Molecular Medicine Berlin, DE 13125, Germany., Pa-Covid SG; Pa-COVID Study Group, Members are listed in the Supplementary Appendix 2., Ripke S; Charite Universitaetsmedizin Berlin, Dept. of Psychiatry and Psychotherapy Chariteplatz 1 d-10117 Berlin, DE 10117, Germany.; Massachusetts General Hospital, Analytic and Translational Genetics, Boston, MA 02114, USA.; Stanley Center for Psychiatry Research, Broad Institute of MIT and Harvard Cambridge MA 02142, USA., Sander LE; Charite Universitaetsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine Berlin, DE 10117, Germany., Beule D; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Core Unit Bioinformatics Berlin, DE 10178, Germany., Landmesser U; Department of Cardiology, Charite Universitaetsmedizin Berlin, DE 12203, Germany.; Berlin Institute of Health at Charité, Berlin, Germany., Guettouche T; Roche Sequencing Solutions Pleasanton, USA 94588., Kurth F; Charite Universitaetsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine Berlin, DE 10117, Germany., Heidecker B; Department of Cardiology, Charite Universitaetsmedizin Berlin, DE 12203, Germany.

Publikováno v: EClinicalMedicine [EClinicalMedicine] 2021 Oct; Vol. 40, pp. 101099. Date of Electronic Publication: 2021 Sep 02.

1800P Concordance between treatment-naive tissue and circulating tumour DNA (ctDNA) in late stage non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC)

Autor: Woestmann, C., Jiang, J., Palma, J.F., Ju, C., Heussel, C.P., Kriegsmann, M., Yaung, S., Thomas, M., Meister, M., Schneider, M., Herth, F., Muley, T., Wehnl, B., Hinzmann, B.

Publikováno v: In Annals of Oncology September 2020 31 Supplement 4:S1041-S1042

Innovative Tumor Tissue Dissection Tool for Molecular Oncology Diagnostics.

Autor: Javey M; Roche Sequencing Solutions, Pleasanton, California. Electronic address: mana.javey@roche.com., Reinsch C; Signature Diagnostics, Potsdam, Germany., Feldkamp M; Signature Diagnostics, Potsdam, Germany., Siemann S; Signature Diagnostics, Potsdam, Germany., Blüher A; Signature Diagnostics, Potsdam, Germany., Woestmann C; Signature Diagnostics, Potsdam, Germany., Cai L; Roche Sequencing Solutions, Pleasanton, California., Tran I; Roche Sequencing Solutions, Pleasanton, California., May T; Roche Sequencing Solutions, Pleasanton, California., Havnar C; Genentech Inc., South San Francisco, California., Lo AA; Genentech Inc., South San Francisco, California., Hinzmann B; Signature Diagnostics, Potsdam, Germany., Heilek G; Roche Sequencing Solutions, Pleasanton, California. Electronic address: gabrielle.heilek@roche.com., Palma JF; Roche Sequencing Solutions, Pleasanton, California.

Publikováno v: The Journal of molecular diagnostics : JMD [J Mol Diagn] 2021 Apr; Vol. 23 (4), pp. 399-406. Date of Electronic Publication: 2021 Jan 23.