A functional sgRNA-CRISPR screening method for generating murine RET and NTRK1 rearranged oncogenes.

Autor: Schubert L; Departments of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO80045, USA., Le AT; Departments of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO80045, USA., Hinz TK; Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, CO80045, USA., Navarro AC; Departments of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO80045, USA., Nelson-Taylor SK; Departments of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO80045, USA., Nemenoff RA; Departments of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO80045, USA., Heasley LE; Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, CO80045, USA.; Eastern Colorado VA Healthcare System, Rocky Mountain Regional VA Medical Center, Aurora, CO80045, USA., Doebele RC; Departments of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO80045, USA.

Publikováno v: Biology open [Biol Open] 2023 Aug 15; Vol. 12 (8). Date of Electronic Publication: 2023 Aug 15.

Novel EGFR-mutant mouse models of lung adenocarcinoma reveal adaptive immunity requirement for durable osimertinib response.

Autor: Kleczko EK; Departments of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Le AT; Departments of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Hinz TK; Departments of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Eastern Colorado VA Healthcare System, Rocky Mountain Regional VA Medical Center, Aurora, CO, USA., Nguyen TT; Departments of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Navarro A; Departments of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Hu CJ; Departments of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Selman AM; Departments of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Clambey ET; Departments of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Merrick DT; Departments of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Lu S; Departments of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Weiser-Evans M; Departments of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Nemenoff RA; Departments of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Electronic address: Raphael.nemenoff@cuanschutz.edu., Heasley LE; Departments of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Eastern Colorado VA Healthcare System, Rocky Mountain Regional VA Medical Center, Aurora, CO, USA. Electronic address: Lynn.heasley@cuanschutz.edu.

Publikováno v: Cancer letters [Cancer Lett] 2023 Mar 01; Vol. 556, pp. 216062. Date of Electronic Publication: 2023 Jan 16.

Durable responses to alectinib in murine models of EML4-ALK lung cancer requires adaptive immunity.

Autor: Kleczko EK; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Hinz TK; Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; Eastern Colorado VA Healthcare System, Rocky Mountain Regional VA Medical Center, Aurora, Colorado, USA., Nguyen TT; Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Gurule NJ; Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Navarro A; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Le AT; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Johnson AM; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Kwak J; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Polhac DI; Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Clambey ET; Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Weiser-Evans M; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Merrick DT; Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Yang MC; Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Patil T; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Schenk EL; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Erin.Schenk@cuanschutz.edu., Heasley LE; Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Lynn.heasley@cuanschutz.edu.; Eastern Colorado VA Healthcare System, Rocky Mountain Regional VA Medical Center, Aurora, Colorado, USA. Lynn.heasley@cuanschutz.edu., Nemenoff RA; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Raphael.nemenoff@cuanschutz.edu.

Publikováno v: NPJ precision oncology [NPJ Precis Oncol] 2023 Feb 04; Vol. 7 (1), pp. 15. Date of Electronic Publication: 2023 Feb 04.

A tyrosine kinase inhibitor-induced interferon response positively associates with clinical response in EGFR-mutant lung cancer.

Autor: Gurule NJ; Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., McCoach CE; Department of Medicine and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA., Hinz TK; Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Merrick DT; Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Van Bokhoven A; Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Kim J; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Patil T; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Calhoun J; Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Nemenoff RA; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Tan AC; Moffitt Cancer Center, Tampa, FL, USA., Doebele RC; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Robert.Doebele@cuanschutz.edu., Heasley LE; Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Lynn.Heasley@cuanschutz.edu.; Eastern Colorado VA Healthcare System, Rocky Mountain Regional VA Medical Center, Aurora, CO, USA. Lynn.Heasley@cuanschutz.edu.

Publikováno v: NPJ precision oncology [NPJ Precis Oncol] 2021 May 17; Vol. 5 (1), pp. 41. Date of Electronic Publication: 2021 May 17.

Translating mesothelioma molecular genomics and dependencies into precision oncology-based therapies.

Autor: Hinz TK; Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, United States., Heasley LE; Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, United States. Electronic address: lynn.heasley@cuanschutz.edu.

Publikováno v: Seminars in cancer biology [Semin Cancer Biol] 2020 Apr; Vol. 61, pp. 11-22. Date of Electronic Publication: 2019 Sep 20.