Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Hinrich Boeger"'
Autor:
Robert Shelansky, Sara Abrahamsson, Christopher R. Brown, Michael Doody, Tineke L. Lenstra, Daniel R. Larson, Hinrich Boeger
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract Fluctuations in the initiation rate of transcription, the first step in gene expression, ensue from the stochastic behavior of the molecular process that controls transcription. In steady state, the regulatory process is often assumed to ope
Externí odkaz:
https://doaj.org/article/2608996d29874af0999a2ab275067895
Autor:
Anushweta Asthana, Parameshwaran Ramanan, Alexander Hirschi, Keelan Z. Guiley, Tilini U. Wijeratne, Robert Shelansky, Michael J. Doody, Haritha Narasimhan, Hinrich Boeger, Sarvind Tripathi, Gerd A. Müller, Seth M. Rubin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The MuvB protein complex regulates genes that are differentially expressed through the cell cycle, yet its precise molecular function has remained unclear. Here the authors reveal MuvB associates with the nucleosome adjacent to the transcription star
Externí odkaz:
https://doaj.org/article/f0c4fe55cb71405cb91f1d9f5b878250
Autor:
Changhui Mao, Christopher R Brown, Elena Falkovskaia, Shawfeng Dong, Eva Hrabeta‐Robinson, Lauren Wenger, Hinrich Boeger
Publikováno v:
Molecular Systems Biology, Vol 6, Iss 1, Pp 1-12 (2010)
Abstract Gene transcription requires a sequence of promoter state transitions, including chromatin remodeling, assembly of the transcription machinery, and clearance of the promoter by RNA polymerase. The rate‐limiting steps in this sequence are re
Externí odkaz:
https://doaj.org/article/e7aa0b57e9b846b38242b8285094fb03
Publikováno v:
PLoS Biology, Vol 11, Iss 8, p e1001621 (2013)
The number of mRNA and protein molecules expressed from a single gene molecule fluctuates over time. These fluctuations have been attributed, in part, to the random transitioning of promoters between transcriptionally active and inactive states, caus
Externí odkaz:
https://doaj.org/article/62f4973d25724669b7cafb93aa7e0d7e
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17521 (2011)
Nucleosomes are believed to inhibit DNA binding by transcription factors. Theoretical attempts to understand the significance of nucleosomes in gene expression and regulation are based upon this assumption. However, nucleosomal inhibition of transcri
Externí odkaz:
https://doaj.org/article/b06b4217321c4af1bf33cf115bc92cfa
Autor:
Robert Shelansky, Sara Abrahamsson, Michael Doody, Christopher R. Brown, Heta P. Patel, Tineke L. Lenstra, Daniel R. Larson, Hinrich Boeger
Transcription occurs in stochastic bursts, i.e., transcription events are temporally clustered. The clustering does not ensue from environmental fluctuations but springs from the intrinsically stochastic behavior of the regulatory process that contro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94271e7122f390108843ddfa968018e5
https://doi.org/10.1101/2022.06.27.497819
https://doi.org/10.1101/2022.06.27.497819
Autor:
Hinrich Boeger
Publikováno v:
Annual review of biochemistry. 91
Biochemistry and molecular biology rely on the recognition of structural complementarity between molecules. Molecular interactions must be both quickly reversible, i.e., tenuous, and specific. How the cell reconciles these conflicting demands is the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f586d1cba97fa0809db49deb238918fb
https://pubmed.ncbi.nlm.nih.gov/35363508
https://pubmed.ncbi.nlm.nih.gov/35363508
Autor:
Keelan Z. Guiley, Haritha Narasimhan, Anushweta Asthana, Hinrich Boeger, Robert Shelansky, Sarvind Tripathi, Alexander Hirschi, Tilini U. Wijeratne, Michael J. Doody, Parameshwaran Ramanan, Gerd A Mueller, Seth M. Rubin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Nature Communications
Nature communications, vol 13, iss 1
Nature Communications
Nature communications, vol 13, iss 1
The chromatin architecture in promoters is thought to regulate gene expression, but it remains uncertain how most transcription factors (TFs) impact nucleosome position. The MuvB TF complex regulates cell-cycle dependent gene-expression and is critic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::900d9970085eac45faa0a4c683573e58
https://doi.org/10.1038/s41467-022-28094-1
https://doi.org/10.1038/s41467-022-28094-1
Autor:
Hinrich Boeger
Publikováno v:
Current Opinion in Systems Biology. 31:100434
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b50ac57e9f7c92587492f92020d28ee
https://doi.org/10.1016/j.coisb.2022.100434
https://doi.org/10.1016/j.coisb.2022.100434
Autor:
Hinrich Boeger, Drew Endy, Namrita Dhillon, Robert Shelansky, Rohinton T. Kamakaka, Miten Jain, Brent Townshend
Publikováno v:
Synthetic biology (Oxford, England), vol 5, iss 1
Synthetic Biology (Oxford, England)
Synthetic Biology (Oxford, England)
Gene expression in Saccharomyces cerevisiae is regulated at multiple levels. Genomic and epigenomic mapping of transcription factors and chromatin factors has led to the delineation of various modular regulatory elements—enhancers (upstream activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::433b1be7223022b9a1e6430d93300c85
https://pubmed.ncbi.nlm.nih.gov/32775697
https://pubmed.ncbi.nlm.nih.gov/32775697