Zobrazeno 1 - 10
of 2 700
pro vyhledávání: '"Hingorani P"'
Autor:
Katherine E. Kabotyanski, Han G. Yi, Rahul Hingorani, Brian S. Robinson, Hannah P. Cowley, Matthew S. Fifer, Brock A. Wester, Bishal Lamichhane, Ashutosh Sabharwal, Anusha B. Allawala, Sameer V. Rajesh, Nabeel Diab, Raissa K. Mathura, Victoria Pirtle, Joshua Adkinson, Andrew J. Watrous, Eleonora Bartoli, Jiayang Xiao, Garrett P. Banks, Sanjay J. Mathew, Wayne K. Goodman, Xaq Pitkow, Nader Pouratian, Benjamin Y. Hayden, Nicole R. Provenza, Sameer A. Sheth
Publikováno v:
Brain Stimulation, Vol 17, Iss 6, Pp 1208-1212 (2024)
Externí odkaz:
https://doaj.org/article/bb7ae1f6ce2a4fac85bdb6d41ef489e5
Autor:
María Gordillo-Marañón, Amand F. Schmidt, Alasdair Warwick, Chris Tomlinson, Cai Ytsma, Jorgen Engmann, Ana Torralbo, Rory Maclean, Reecha Sofat, Claudia Langenberg, Anoop D. Shah, Spiros Denaxas, Munir Pirmohamed, Harry Hemingway, Aroon D. Hingorani, Chris Finan
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-11 (2024)
Abstract Background Despite the growing interest in the use of human genomic data for drug target identification and validation, the extent to which the spectrum of human disease has been addressed by genome-wide association studies (GWAS), or by dru
Externí odkaz:
https://doaj.org/article/14ac4ccb0e8349ce89515b8fe565b434
Autor:
Mohan Hingorani, Hannah Stubley
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 5, Iss 4, Pp 921-930 (2024)
The prognosis of metastatic esophageal cancer (EC) remains poor with an average life expectancy of around 9–12 months with standard systemic chemotherapy. The concept of oligometastatic disease (OMD) in EC cancer is controversial with no universall
Externí odkaz:
https://doaj.org/article/9cff5f06fc0f47d0bb093678c61711a2
Comparing the effects of CETP in East Asian and European ancestries: a Mendelian randomization study
Autor:
Diana Dunca, Sandesh Chopade, María Gordillo-Marañón, Aroon D. Hingorani, Karoline Kuchenbaecker, Chris Finan, Amand F. Schmidt
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract CETP inhibitors are a class of lipid-lowering drugs in development for treatment of coronary heart disease (CHD). Genetic studies in East Asian ancestry have interpreted the lack of CETP signal with low-density lipoprotein cholesterol (LDL-C
Externí odkaz:
https://doaj.org/article/23e5af9de5984d279421ac7ebb2dc74e
Autor:
Andrés M. Arias-Lorza, James R. Costello, Sunil R. Hingorani, Daniel D. Von Hoff, Ronald L. Korn, Natarajan Raghunand
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Pre-clinical and clinical studies have shown that PEGPH20 depletes intratumoral hyaluronic acid (HA), which is linked to high interstitial fluid pressures and poor distribution of chemotherapies. 29 patients with metastatic advanced solid tu
Externí odkaz:
https://doaj.org/article/efc4f39a74d3420ca38b41a64d4c8737
Autor:
Constantin-Cristian Topriceanu, Mit Shah, Matthew Webber, Fiona Chan, Hunain Shiwani, Marcus Richards, Jonathan Schott, Nishi Chaturvedi, James C. Moon, Alun D. Hughes, Aroon D. Hingorani, Declan P. O’Regan, Gabriella Captur
Publikováno v:
BMC Cardiovascular Disorders, Vol 24, Iss 1, Pp 1-17 (2024)
Abstract Background Although APOE ε4 allele carriage confers a risk for coronary artery disease, its persistence in humans might be explained by certain survival advantages (antagonistic pleiotropy). Methods Combining data from ~ 37,000 persons from
Externí odkaz:
https://doaj.org/article/11cdd86813114bbcb62a5c1ef1c08698
Publikováno v:
Journal of Clinical Ophthalmology and Research, Vol 12, Iss 3, Pp 340-341 (2024)
Externí odkaz:
https://doaj.org/article/938290d6bf2049a5a1247ad56457ffaf
Autor:
Seth Lieberman, Daniel A. Rivera, Ryan Morton, Amrit Hingorani, Teresa L. Southard, Lynn Johnson, Jennifer Reukauf, Ryan E. Radwanski, Mingrui Zhao, Nozomi Nishimura, Oliver Bracko, Theodore H. Schwartz, Chris B. Schaffer
Publikováno v:
Advanced Science, Vol 11, Iss 29, Pp n/a-n/a (2024)
Abstract In partial onset epilepsy, seizures arise focally in the brain and often propagate. Patients frequently become refractory to medical management, leaving neurosurgery, which can cause neurologic deficits, as a primary treatment. In the cortex
Externí odkaz:
https://doaj.org/article/d22684f893044b91ac604fc32f314fdc
Autor:
Gregory Y H Lip, Kenneth K C Man, Wallis C Y Lau, Ian C K Wong, Wai K Leung, Aroon D Hingorani, Pajaree Mongkhon, Jan D Chobanov, Zixuan Wang, Edil Dayib
Publikováno v:
Open Heart, Vol 11, Iss 2 (2024)
Aims Women with atrial fibrillation (AF) are under-represented in randomised controlled trials (RCTs) of direct oral anticoagulants (DOACs). This systematic review and meta-analysis of RCTs and observational studies examined sex-specific outcomes of
Externí odkaz:
https://doaj.org/article/c80def62b06a4424a387ca21bb6dabe0
Autor:
A. Floriaan Schmidt, Chris Finan, Sandesh Chopade, Stephan Ellmerich, Martin N. Rossor, Aroon D. Hingorani, Mark B. Pepys
Publikováno v:
Open Biology, Vol 14, Iss 7 (2024)
The mechanisms responsible for neuronal death causing cognitive loss in Alzheimer's disease (AD) and many other dementias are not known. Serum amyloid P component (SAP) is a constitutive plasma protein, which is cytotoxic for cerebral neurones and al
Externí odkaz:
https://doaj.org/article/7b7fa5020a354c8684a1fb1ebee1aca7