Zobrazeno 1 - 10
of 316
pro vyhledávání: '"Hing Y, Leung"'
Autor:
Parisa Dehghani, Vaithinathan Karthikeyan, Ataollah Tajabadi, Dani S. Assi, Anthony Catchpole, John Wadsworth, Hing Y. Leung, Vellaisamy A. L. Roy
Publikováno v:
ACS Omega, Vol 9, Iss 12, Pp 14580-14591 (2024)
Externí odkaz:
https://doaj.org/article/4810410b839e48159fa9009b82b61cec
Publikováno v:
Cancer Medicine, Vol 12, Iss 22, Pp 20830-20837 (2023)
Abstract Background Risk of biochemical recurrence (BCR) in localised prostate cancer can be stratified using the 5‐tier Cambridge Prognostic Group (CPG) or 3‐tier European Association of Urology (EAU) model. Active surveillance is the current re
Externí odkaz:
https://doaj.org/article/b134d1283a5a4c9bad914f946a7df605
Autor:
Eva C. Freckmann, Emma Sandilands, Erin Cumming, Matthew Neilson, Alvaro Román-Fernández, Konstantina Nikolatou, Marisa Nacke, Tamsin R. M. Lannagan, Ann Hedley, David Strachan, Mark Salji, Jennifer P. Morton, Lynn McGarry, Hing Y. Leung, Owen J. Sansom, Crispin J. Miller, David M. Bryant
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
There are currently a lack of tools to detect heterogeneity in 3D cultures. Here the authors report Traject3d as a framework to identify heterogeneous states in 3D culture and to understand how these give rise to distinct phenotypes using label-free
Externí odkaz:
https://doaj.org/article/d1ea5c3909d0472cb9c9c41a696d4ec5
Autor:
Arnaud Blomme, Coralie Peter, Ernest Mui, Giovanny Rodriguez Blanco, Ning An, Louise M Mason, Lauren E Jamieson, Grace H McGregor, Sergio Lilla, Chara Ntala, Rachana Patel, Marc Thiry, Sonia H Y Kung, Marine Leclercq, Catriona A Ford, Linda K Rushworth, David J McGarry, Susan Mason, Peter Repiscak, Colin Nixon, Mark J Salji, Elke Markert, Gillian M MacKay, Jurre J Kamphorst, Duncan Graham, Karen Faulds, Ladan Fazli, Martin E Gleave, Edward Avezov, Joanne Edwards, Huabing Yin, David Sumpton, Karen Blyth, Pierre Close, Daniel J Murphy, Sara Zanivan, Hing Y Leung
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 3, Pp 1-21 (2022)
Abstract Despite the clinical benefit of androgen‐deprivation therapy (ADT), the majority of patients with advanced prostate cancer (PCa) ultimately develop lethal castration‐resistant prostate cancer (CRPC). In this study, we identified thioeste
Externí odkaz:
https://doaj.org/article/0b32d6de175042e18b789240104f3924
Autor:
Chara Ntala, Mark Salji, Jonathan Salmond, Leah Officer, Ana Vieira Teodosio, Arnaud Blomme, Ewan J. McGhee, Ian Powley, Imran Ahmad, Marianna Kruithof-de Julio, George Thalmann, Ed Roberts, Carl S. Goodyear, Tamara Jamaspishvili, David M. Berman, Leo M. Carlin, John Le Quesne, Hing Y. Leung
Publikováno v:
European Urology Open Science, Vol 29, Iss , Pp 19-29 (2021)
Background: Pelvic nodal metastasis in prostate cancer impacts patient outcome negatively. Objective: To explore tumor-infiltrating immune cells as a potential predictive tool for regional lymph node (LN) metastasis. Design, setting, and participants
Externí odkaz:
https://doaj.org/article/ba12c3a2a624488381047889f1ca7d08
Autor:
Marisa Nacke, Emma Sandilands, Konstantina Nikolatou, Álvaro Román-Fernández, Susan Mason, Rachana Patel, Sergio Lilla, Tamas Yelland, Laura C. A. Galbraith, Eva C. Freckmann, Lynn McGarry, Jennifer P. Morton, Emma Shanks, Hing Y. Leung, Elke Markert, Shehab Ismail, Sara Zanivan, Karen Blyth, David M. Bryant
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
The signalling pathways underpinning cell growth and invasion use overlapping components, yet how mutually exclusive responses occur is unclear. Here, the authors show that alternate isoforms of the ARF GTPase exchange factor IQSEC1 direct phosphoino
Externí odkaz:
https://doaj.org/article/5313ed90f36c4817a2437ea2428b588c
Autor:
Maha AlRasheedi, Sai Han, Helene Thygesen, Matt Neilson, Fraser Hendry, Ahmed Alkarn, John D. Maclay, Hing Y. Leung
Publikováno v:
Diagnostics, Vol 13, Iss 7, p 1209 (2023)
18F-FDG positron emission tomography with computed tomography (PET/CT) is a standard imaging modality for the nodal staging of non-small cell lung cancer (NSCLC). To improve the accuracy of pre-operative staging, we compare the staging accuracy of me
Externí odkaz:
https://doaj.org/article/8977148489ec4f46b5eb0d7720bcc254
Autor:
Keiran D Clement, Lizzy Day, Helen Rooney, Matt Neilson, Fiona Birrell, Mark Salji, Elizabeth Norman, Ross Clark, Amit Patel, John Morrison, Hing Y Leung
Publikováno v:
Asian Journal of Andrology, Vol 23, Iss 3, Pp 231-235 (2021)
Lack of investment for magnetic resonance (MR) fusion systems is an obstacle to deliver targeted prostate biopsies within the prostate cancer diagnostic pathway. We developed a coordinate-based method to support cognitive targeted prostate biopsies a
Externí odkaz:
https://doaj.org/article/f36a5939be6547f48599213ef2de53c7
Autor:
Mark J. Salji, Arnaud Blomme, J. Henry M. Däbritz, Peter Repiscak, Sergio Lilla, Rachana Patel, David Sumpton, Niels J.F. van den Broek, Ronan Daly, Sara Zanivan, Hing Y. Leung
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104056- (2022)
Summary: Castration-resistant prostate cancer (CRPC) is incurable and remains a significant worldwide challenge (Oakes and Papa, 2015). Matched untargeted multi-level omic datasets may reveal biological changes driving CRPC, identifying novel biomark
Externí odkaz:
https://doaj.org/article/3805fc748f104f7ba51eabf9fb2117d5
Autor:
Arnaud Blomme, Catriona A. Ford, Ernest Mui, Rachana Patel, Chara Ntala, Lauren E. Jamieson, Mélanie Planque, Grace H. McGregor, Paul Peixoto, Eric Hervouet, Colin Nixon, Mark Salji, Luke Gaughan, Elke Markert, Peter Repiscak, David Sumpton, Giovanny Rodriguez Blanco, Sergio Lilla, Jurre J. Kamphorst, Duncan Graham, Karen Faulds, Gillian M. MacKay, Sarah-Maria Fendt, Sara Zanivan, Hing Y. Leung
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Androgen receptor (AR) signalling regulates cellular metabolism in prostate cancer. Here, the authors perform a proteomics and metabolomics characterisation of prostate cancer cells adapted to long-term resistance to AR inhibition and show rewiring o
Externí odkaz:
https://doaj.org/article/2a468699bc1a4fa682a39a1ff7c055bc