Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Hing Sham"'
Autor:
Alexey Dementiev, Abel Silva, Calvin Yee, Zhe Li, Michael T. Flavin, Hing Sham, James R. Partridge
Publikováno v:
Blood Advances, Vol 2, Iss 5, Pp 549-558 (2018)
Abstract: Activated factor XIIa (FXIIa) is a serine protease that has received a great deal of interest in recent years as a potential target for the development of new antithrombotics. Despite the strong interest in obtaining structural information,
Externí odkaz:
https://doaj.org/article/7129089a7ea744118c8a866d33651f42
Autor:
Ying Zhang, James R. Partridge, Qiong Xu, Peter Rademacher, Zhe Li, Andreas Betz, Haijuan Shi, Hing Sham, Abel Silva-Garcia, Li Zhang, Xubo Ma, Bin Liu, Qing Xu, Yuqing Shan, Yunjin Hu
Publikováno v:
ACS Medicinal Chemistry Letters. 8:185-190
A series of macrocyclic analogues were designed and synthesized based on the cocrystal structure of small molecule plasma kallikrein (pKal) inhibitor, 2, with the pKal protease domain. This led to the discovery of a potent macrocyclic pKal inhibitor
Autor:
Brian Metcalf, Abel Silva-Garcia, Rebeca M. Choy, Zhe Li, James R. Partridge, Chul Yu, Hing Sham
Publikováno v:
Journal of structural biology. 206(2)
Plasma kallikrein (pKal) is a serine protease responsible for cleaving high-molecular-weight kininogen to produce the pro-inflammatory peptide, bradykinin. Unregulated pKal activity can lead to hereditary angioedema (HAE) following excess bradykinin
Autor:
Wang Shen, Fakhoury, Stephen, Donner, Greg, Henry, Kenneth, Lee, Jang, Haichao Zhang, Cohen, Jerry, Warner, Robert, Saeed, Badr, Cherian, Sajeev, Tahir, Stephen, Kovar, Peter, Bauch, Joy, Shi-Chung Ng, Marsh, Kennan, Hing Sham, Rosenberg, Saul
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1999 9(5):703-708
Autor:
Jingsong Zhao, Patrick Rudewicz, George Tonn, Hing Sham, Ming Chen, Elizabeth F. Brigham, Manuel Buttini, Daniel Ness, Erich Goldbach, William H. Jordan, William Wallace, Anna Liao, Gary Probst
Publikováno v:
Alzheimer's & Dementia. 7
Autor:
Normand Frigon, John P. Anderson, Kyle Powell, Guriqbal S. Basi, Carla Ramos, Frederique Bard, Ruth Motter, Irene Griswold-Prenner, David Chian, Ted Yednock, Kelly J. Inglis, Jason Goldstein, Hing Sham, Lisa McConlogue, Seth Nelson, Elizabeth F. Brigham, Russell J. Caccavello, Mei Yu, David Chereau, Ferdie Soriano, Susanne Schöbel, San-San Chiou, Michael Babcock, Sarah Wright, Tamie J. Chilcote, Pamela Santiago
Publikováno v:
The Journal of Biological Chemistry
Several neurological diseases, including Parkinson disease and dementia with Lewy bodies, are characterized by the accumulation of alpha-synuclein phosphorylated at Ser-129 (p-Ser-129). The kinase or kinases responsible for this phosphorylation have
Autor:
Zehan, Chen, Zhan, Xiao, Jun, Chen, Shi-Chung, Ng, Thomas, Sowin, Hing, Sham, Saul, Rosenberg, Steve, Fesik, Haiying, Zhang
Publikováno v:
Molecular cancer therapeutics. 2(6)
Mammalian Chk1 is an essential kinase for embryonic development and plays an important role in the cellular response to DNA damage. However, it remains unclear whether inhibition of Chk1 induces apoptosis in somatic cells. The uncertainty has become
Publikováno v:
Proteins ISBN: 9789401090650
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::caadc685eea3ff33d19c3b6270536d76
https://doi.org/10.1007/978-94-010-9063-6_40
https://doi.org/10.1007/978-94-010-9063-6_40