Zobrazeno 1 - 10
of 433
pro vyhledávání: '"Hing Leung"'
Publikováno v:
Diagnostics, Vol 9, Iss 1, p 21 (2019)
Prostate cancer (PCa) diagnosis with current biomarkers is difficult and often results in unnecessary invasive procedures as well as over-diagnosis and over-treatment, highlighting the need for novel biomarkers. The aim of this review is to provide a
Externí odkaz:
https://doaj.org/article/7722d5c900f14c0c97e9bbab4332d88f
Autor:
Jochen Neuhaus, Eric Schiffer, Philine von Wilcke, Hartwig W Bauer, Hing Leung, Justyna Siwy, Wolfram Ulrici, Uwe Paasch, Lars-Christian Horn, Jens-Uwe Stolzenburg
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67514 (2013)
BACKGROUND: Extensive prostate specific antigen screening for prostate cancer generates a high number of unnecessary biopsies and over-treatment due to insufficient differentiation between indolent and aggressive tumours. We hypothesized that seminal
Externí odkaz:
https://doaj.org/article/ea0d54b89240420db53b30b52e1bf562
Autor:
David E. Neal, Hayley C. Whitaker, Freddie Hamdy, Hing Leung, Kanagasabai Sahadevan, Ian G. Mills, Anne Y. Warren, Joanne Girling, Hayley J. Thirkettle
Purpose: LYRIC/AEG-1 has been reported to influence breast cancer survival and metastases, and its altered expression has been found in a number of cancers. The cellular function of LYRIC/AEG-1 has previously been related to its subcellular distribut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31b3f6f61849ce9a5d5fc7e6e1cdd637
https://doi.org/10.1158/1078-0432.c.6517383.v1
https://doi.org/10.1158/1078-0432.c.6517383.v1
Autor:
David E. Neal, Hayley C. Whitaker, Freddie Hamdy, Hing Leung, Kanagasabai Sahadevan, Ian G. Mills, Anne Y. Warren, Joanne Girling, Hayley J. Thirkettle
Supplementary Data from LYRIC/AEG-1 Is Targeted to Different Subcellular Compartments by Ubiquitinylation and Intrinsic Nuclear Localization Signals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::095a668b4ea641b102280931ad33c280
https://doi.org/10.1158/1078-0432.22440003.v1
https://doi.org/10.1158/1078-0432.22440003.v1
Autor:
Gerhardt Attard, Marina Parry, Emily Grist, Larissa Mendes, Peter Dutey-Magni, Ashwin Sachdeva, Christopher Brawley, Laura Murphy, James Proudfoot, Sharanpreet Lall, Yang Liu, Stefanie Friedrich, Mazlina Ismail, Alex Hoyle, Adnan Ali, Aine Haran, Anna Wingate, Leila Zakka, Daniel Wetterskog, Claire Amos, Nafisah Atako, Victoria Wang, Hannah Rush, Robert Jones, Hing Leung, William Cross, silke gillessen, Chris Parker, Simon Chowdhury, Tamara Lotan, Teresa Marafioti, Alfonso Urbanucci, Edward Schaeffer, Daniel Spratt, David Waugh, Thomas Powles, Daniel Berney, Matthew Sydes, Mahesh Parmar, Anis Hamid, Felix Feng, Christopher Sweeney, Elai Davicioni, Noel Clarke, Nicholas James, Louise Brown
Metastatic and high-risk localized prostate cancer respond to hormone therapy but outcomes vary. Following a pre-specified statistical plan, we used Cox models adjusted for clinical variables to test associations with survival of multi-gene expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8da64509c94365ee97991542c6f91822
https://doi.org/10.21203/rs.3.rs-2488586/v1
https://doi.org/10.21203/rs.3.rs-2488586/v1
Autor:
Yu Chen, Samual Hee, Xiaochen Liu, Sajal Das, Dongsub Hong, Pak-Hing Leung, Yongxin Li, Jiaming Li, Jianbo Liu
Publikováno v:
J Org Chem
An ICl-mediated highly chemo- and regioselective functional group interconversion from methyl homopropargyl ether to α-iodo-γ-chloro-ketone is reported. Density functional theory (DFT)-calculated reaction coordinate and potential energy surface sup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::593bd66b9c44354bf6efde266e7f5cad
https://europepmc.org/articles/PMC10174042/
https://europepmc.org/articles/PMC10174042/
Autor:
Wen Qian Shum, Ronald Hong Xiang Teo, Wei Ren Tan, Jeannie Xue Ting Lee, Nguan Soon Tan, Pak-Hing Leung, Sumod A. Pullarkat, Yongxin Li
Publikováno v:
Organometallics. 40:3454-3461
Publikováno v:
Organometallics. 40:2118-2122
Enantioenriched phosphine azoles were synthesized in high yields via palladium-catalyzed asymmetric hydrophosphination with excellent yields and enantioselectivities under mild reaction conditions. One of the phosphine azoles was methylated and compl
HNRNPA2B1 controls an unfolded protein response-related prognostic gene signature in prostate cancer
Autor:
John G Foster, Esteban Gea, Mosammat A Labiba, Chinedu A Anene, Jacqui Stockley, Celine Philippe, Matteo Cereda, Kevin Rouault-Pierre, Hing Leung, Conrad Bessant, Prabhakar Rajan
HNRNPA2B1 is associated with prostate cancer (PC) disease aggressiveness and underlies pro-tumourigenic cellular stress responses. By analysing >500 PC transcriptomes, we reveal that HNRNPA2B1 over-expression is associated with poor patient prognosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0bcf19dcb163884ad39dd79d34f8d52
http://hdl.handle.net/2434/932169
http://hdl.handle.net/2434/932169
Publikováno v:
Organometallics. 40:682-692
A series of PN(sp2)P ligands containing two stereogenic carbon centers were generated via the palladium(II) catalyzed asymmetric hydrophosphination of 2,6-pyridyl dienones using diphenylphosphine. ...