Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Hindupur K. Anandatheerthavarada"'
Autor:
Naresh Babu V. Sepuri, Narayan G. Avadhani, Carolyn K. Suzuki, Joseph F. Spear, Manti Guha, Bin Lu, Satish Srinivasan, Rajesh Angireddy, Hindupur K. Anandatheerthavarada
The mitochondrial ATP dependent matrix protease, Lon, is involved in the maintenance of mitochondrial DNA nucleoids and degradation of abnormal or misfolded proteins. The Lon protease regulates mitochondrial Tfam (mitochondrial transcription factor A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a07724bd6266422c6f921523b673397
https://europepmc.org/articles/PMC5507603/
https://europepmc.org/articles/PMC5507603/
Autor:
Hindupur K. Anandatheerthavarada, F. Peter Guengerich, Anindya Roy Chowdhury, Seema Bansal, Frank J. Gonzalez, Adrian N. Leu, Narayan G. Avadhani
Publikováno v:
Journal of Biological Chemistry. 289:9936-9951
We report that polycyclic aromatic hydrocarbon (PAH)-inducible CYP1B1 is targeted to mitochondria by sequence-specific cleavage at the N terminus by a cytosolic Ser protease (polyserase 1) to activate the cryptic internal signal. Site-directed mutage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b26c483179ad421e78efc403e958248
https://doi.org/10.1074/jbc.m113.525659
https://doi.org/10.1074/jbc.m113.525659
Autor:
F. Peter Guengerich, Narayan G. Avadhani, Martha V. Martin, Hindupur K. Anandatheerthavarada, Michelle C Sangar
Publikováno v:
Molecular Genetics and Metabolism. 99:90-97
Human cytochrome P450 2D6 (CYP2D6) is responsible for the metabolism of approximately 20% of drugs in common clinical use. The CYP2D6 gene locus is highly polymorphic. Many of the polymorphisms have been shown to be clinically relevant and can accoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7252f9c7761b56fcdbe8a5ec4b377bbb
https://doi.org/10.1016/j.ymgme.2009.08.009
https://doi.org/10.1016/j.ymgme.2009.08.009
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1802:11-19
Mitochondrial dysfunction is an important intracellular lesion associated with a wide variety of diseases including neurodegenerative disorders. In addition to aging, oxidative stress and mitochondrial DNA mutations, recent studies have implicated a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9c0c6f76584d1ade9feba4368b500b1
https://doi.org/10.1016/j.bbadis.2009.07.007
https://doi.org/10.1016/j.bbadis.2009.07.007
Autor:
F. Peter Guengerich, Subbuswamy K. Prabu, Michelle C Sangar, Weigang Tang, Miroslav Dostálek, Martha V. Martin, Hindupur K. Anandatheerthavarada, Narayan G. Avadhani
Publikováno v:
FEBS Journal. 276:3440-3453
Constitutively expressed human cytochrome P450 2D6 (CYP2D6; EC 1.14.14.1) is responsible for the metabolism of approximately 25% of drugs in common clinical use. It is widely accepted that CYP2D6 is localized in the endoplasmic reticulum of cells; ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e39cd1608cb100c3932a0fc7dc25f18
https://doi.org/10.1111/j.1742-4658.2009.07067.x
https://doi.org/10.1111/j.1742-4658.2009.07067.x
Publikováno v:
Journal of Biological Chemistry. 284:17352-17363
Previously we showed that xenobiotic inducible cytochrome P450 (CYP) proteins are bimodally targeted to the endoplasmic reticulum and mitochondria. In this study, we investigated the mechanism of delivery of chimeric signal containing CYP proteins to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2644dfa63233e6e1888b9272324d0b3d
https://doi.org/10.1074/jbc.m109.007492
https://doi.org/10.1074/jbc.m109.007492
Publikováno v:
Proceedings of the National Academy of Sciences. 105:186-191
The environmental toxin 2,3,7,8-tetrachlorodibenzodioxin (TCDD) is a known human carcinogen; however, its precise mechanism of action remains unclear. Here we show that TCDD induces mitochondrial dysfunction, stress signaling, and tumor invasion by a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9bd26c09261e43ef96d7f710b501a0
https://doi.org/10.1073/pnas.0706183104
https://doi.org/10.1073/pnas.0706183104
Publikováno v:
FEBS Journal. 274:4615-4630
Previously we showed that intact rat cytochrome P450 2E1, cytochrome P450 2B1 and truncated cytochrome P450 1A1 are targeted to mitochondria in rat tissues and COS cells. However, some reports suggest that truncated cytochrome P450 2E1 is targeted to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfcf3500d0b8c4c220f199a55afa80b6
https://doi.org/10.1111/j.1742-4658.2007.05990.x
https://doi.org/10.1111/j.1742-4658.2007.05990.x
Autor:
Narayan G. Avadhani, Haider Raza, Ji-Kang Fang, Naresh Babu V. Sepuri, Joseph F. Spear, Hindupur K. Anandatheerthavarada, Subbuswamy K. Prabu, Domenico F. Galati
Publikováno v:
FEBS Letters. 581:1302-1310
We have mapped the sites of ischemia/reperfusion-induced phosphorylation of cytochrome c oxidase (CcO) subunits in rabbit hearts by using a combination of Blue Native gel/Tricine gel electrophoresis and nano-LC–MS/MS approaches. We used precursor i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e1df486ff0964d9eec6e2a148d3eb62
https://doi.org/10.1016/j.febslet.2007.02.042
https://doi.org/10.1016/j.febslet.2007.02.042
Autor:
Hindupur K. Anandatheerthavarada, Domenico F. Galati, Latha Devi, Badanavalu M. Prabhu, Narayan G. Avadhani
Publikováno v:
The Journal of Neuroscience. 26:9057-9068
Mitochondrial dysfunction is one of the major intracellular lesions of Alzheimer’s disease (AD). However, the causative factors involved in the mitochondrial dysfunction in human AD are not well understood. Here we report that nonglycosylated full-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f2e1afbd9fb85737df0d71a06b20b6d
https://doi.org/10.1523/jneurosci.1469-06.2006
https://doi.org/10.1523/jneurosci.1469-06.2006