Glycosylation increases active site rigidity leading to improved enzyme stability and turnover.

Autor: Ramakrishnan K; Molecular Biosciences Division, School of Biosciences, Cardiff University, UK., Johnson RL; Molecular Biosciences Division, School of Biosciences, Cardiff University, UK., Winter SD; Department of Biology and Biochemistry, University of Bath, UK., Worthy HL; Molecular Biosciences Division, School of Biosciences, Cardiff University, UK.; Biosciences, Faculty of Health and Life Sciences, University of Exeter, UK., Thomas C; Ortho Clinical Diagnostics, Pencoed, UK., Humer DC; Institute of Chemical, Environmental and Bioscience Engineering, Research Area Biochemical Engineering, TU Wien, Austria., Spadiut O; Institute of Chemical, Environmental and Bioscience Engineering, Research Area Biochemical Engineering, TU Wien, Austria., Hindson SH; Department of Biology and Biochemistry, University of Bath, UK., Wells S; Department of Physics, University of Bath, UK., Barratt AH; Molecular Biosciences Division, School of Biosciences, Cardiff University, UK., Menzies GE; Molecular Biosciences Division, School of Biosciences, Cardiff University, UK., Pudney CR; Department of Biology and Biochemistry, University of Bath, UK.; Centre for Therapeutic Innovation, University of Bath, UK., Jones DD; Molecular Biosciences Division, School of Biosciences, Cardiff University, UK.

Publikováno v: The FEBS journal [FEBS J] 2023 Aug; Vol. 290 (15), pp. 3812-3827. Date of Electronic Publication: 2023 Apr 03.