Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Hinda Najem"'
Autor:
Hinda Najem, Sebastian Pacheco, Joanna Kowal, Dan Winkowski, Jared K. Burks, Amy B. Heimberger
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 103079- (2024)
Summary: Although myeloid-derived immune cells can be dispersed throughout the tumor microenvironment (TME), anti-tumor effector cells are confined to the perivascular space. Here, we present a protocol to quantify immune cell distribution from tumor
Externí odkaz:
https://doaj.org/article/baf06e8319234ab6b7e144beab5706b1
Autor:
Mark W. Youngblood, Zeynep Erson-Omay, Chang Li, Hinda Najem, Süleyman Coșkun, Evgeniya Tyrtova, Julio D. Montejo, Danielle F. Miyagishima, Tanyeri Barak, Sayoko Nishimura, Akdes Serin Harmancı, Victoria E. Clark, Daniel Duran, Anita Huttner, Timuçin Avşar, Yasar Bayri, Johannes Schramm, Julien Boetto, Matthieu Peyre, Maximilien Riche, Roland Goldbrunner, Nduka Amankulor, Angeliki Louvi, Kaya Bilgüvar, M. Necmettin Pamir, Koray Özduman, Türker Kilic, James R. Knight, Matthias Simon, Craig Horbinski, Michel Kalamarides, Marco Timmer, Amy B. Heimberger, Ketu Mishra-Gorur, Jennifer Moliterno, Katsuhito Yasuno, Murat Günel
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Hedgehog signaling mediates embryologic development of the central nervous system and other tissues and is frequently hijacked by neoplasia to facilitate uncontrolled cellular proliferation. Meningiomas, the most common primary brain tumor,
Externí odkaz:
https://doaj.org/article/32c53254d0434114aadc0376769d30b2
Autor:
David Hou, Hanxiao Wan, Joshua L. Katz, Si Wang, Brandyn A. Castro, Gustavo I. Vazquez-Cervantes, Victor A. Arrieta, Silpol Dhiantravan, Hinda Najem, Aida Rashidi, Tzu-yi Chia, Tarlan Arjmandi, Jimena Collado, Leah Billingham, Aurora Lopez-Rosas, Yu Han, Adam M. Sonabend, Amy B. Heimberger, Peng Zhang, Jason Miska, Catalina Lee-Chang
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Understanding the spatial relationship and functional interaction of immune cells in glioblastoma (GBM) is critical for developing new therapeutics that overcome the highly immunosuppressive tumor microenvironment. Our study showed that B and T cells
Externí odkaz:
https://doaj.org/article/6ecf574030ed40ef851a4a0c31efda84
Autor:
Ruochen Du, Shashwat Tripathi, Hinda Najem, Daniel J. Brat, Rimas V. Lukas, Peng Zhang, Amy B. Heimberger
Publikováno v:
Cells, Vol 13, Iss 10, p 823 (2024)
Macrophages and microglia are professional phagocytes that sense and migrate toward “eat-me” signals. The role of phagocytic cells is to maintain homeostasis by engulfing senescent or apoptotic cells, debris, and abnormally aggregated macromolecu
Externí odkaz:
https://doaj.org/article/6bc6d5a7ca8d412085c42601a729f555
Autor:
Xingsheng Ren, Laura D. Manzanares, Enzo B. Piccolo, Jessica M. Urbanczyk, David P. Sullivan, Lenore K. Yalom, Triet M. Bui, Connor Lantz, Hinda Najem, Parambir S. Dulai, Amy B. Heimberger, Edward B. Thorp, Ronen Sumagin
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 15 (2023)
Neutrophil (PMN) mobilization to sites of insult is critical for host defense and requires transendothelial migration (TEM). TEM involves several well-studied sequential adhesive interactions with vascular endothelial cells (ECs); however, what initi
Externí odkaz:
https://doaj.org/article/8ae8d8ce502040ed92460113def273bc
Autor:
Jun Wei, Renduo Song, Aria Sabbagh, Anantha Marisetty, Neal Shukla, Dexing Fang, Hinda Najem, Martina Ott, James Long, Lijie Zhai, Maciej S. Lesniak, Charles David James, Leonidas Platanias, Michael Curran, Amy B. Heimberger
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Osteopontin (OPN) is produced by tumor cells as well as by myeloid cells and is enriched in the tumor microenvironment (TME) of many cancers. Given the roles of OPN in tumor progression and immune suppression, we hypothesized that targeting OPN with
Externí odkaz:
https://doaj.org/article/9a2cece667ae44a28de1cd480b3450df
Autor:
Shreya Budhiraja, Hinda Najem, Shashwat Tripathi, Nitin R. Wadhawani, Craig Horbinski, Matthew McCord, Alicia C. Lenzen, Amy B. Heimberger, Michael DeCuypere
Publikováno v:
Cancers, Vol 15, Iss 14, p 3655 (2023)
Utilizing a Scoping Review strategy in the domain of immune biology to identify immune therapeutic targets, knowledge gaps for implementing immune therapeutic strategies for pediatric brain tumors was assessed. The analysis demonstrated limited effor
Externí odkaz:
https://doaj.org/article/b3b40473248940eab1e46b2842fa5857
Autor:
Moloud Sooreshjani, Shashwat Tripathi, Corey Dussold, Hinda Najem, John de Groot, Rimas V. Lukas, Amy B. Heimberger
Publikováno v:
Cancers, Vol 15, Iss 14, p 3739 (2023)
Cytokines play an important role in regulating the immune response. Although there is great interest in exploiting cytokines for cancer immunotherapy, their clinical potential is limited by their pleiotropic properties and instability. A variety of c
Externí odkaz:
https://doaj.org/article/be0a11fd90b748ce8fb6b1b716480c3c
Autor:
Amy B Heimberger, David M Ashley, Charles David James, Alexander H Stegh, Michael A Curran, Peng Zhang, Justin T Low, Hinda Najem, Akanksha Sanjay Mahajan, Shashwat Tripathi
Publikováno v:
F1000Research, Vol 11 (2022)
Median survival of patients with glioblastoma (GBM) treated with standard of care which consists of maximal safe resection of the contrast-enhancing portion of the tumor followed by radiation therapy with concomitant adjuvant temozolomide (TMZ) remai
Externí odkaz:
https://doaj.org/article/087941a9a6a140c686f1b957e6d06943
Autor:
Collin J. Larkin, Víctor A. Arrieta, Hinda Najem, Gongbo Li, Peng Zhang, Jason Miska, Peiwen Chen, Charles David James, Adam M. Sonabend, Amy B. Heimberger
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The glioma tumor microenvironment (TME) is complex and heterogeneous, and multiple emerging and current technologies are being utilized for an improved comprehension and understanding of these tumors. Single cell analysis techniques such as single ce
Externí odkaz:
https://doaj.org/article/91cd612427b341e3acf22d05b23a71a7