Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Hind J Fadel"'
Autor:
Defne Gunes Ergi, MD, Hind J. Fadel, MD, Hector I. Michelena, MD, Grace Lin, MD, Kevin L. Greason, MD, Arman Arghami, MD, MPH
Publikováno v:
Texas Heart Institute Journal, Vol 51, Iss 2, Pp 1-4 (2024)
Whipple disease is a rare systemic illness associated with weight loss, diarrhea, and arthralgia. Asymptomatic carriage is common, but the disease can be complicated by cardiac involvement and may result in culture-negative endocarditis. Cardiac mani
Externí odkaz:
https://doaj.org/article/9f6832ae9fa64bef97f09a13069cac25
Autor:
Jennifer M Reiman, Biswadeep Das, Gregory M Sindberg, Mark D Urban, Madeleine E M Hammerlund, Han B Lee, Katie M Spring, Jamie Lyman-Gingerich, Alex R Generous, Tyler H Koep, Kevin Ewing, Phil Lilja, Felicity T Enders, Stephen C Ekker, W Charles Huskins, Hind J Fadel, Chris Pierret
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0204337 (2018)
Influenza is a global problem infecting 5-10% of adults and 20-30% of children annually. Non-pharmaceutical interventions (NPIs) are attractive approaches to complement vaccination in the prevention and reduction of influenza. Strong cyclical reducti
Externí odkaz:
https://doaj.org/article/9f84f6e74b434b55be8f7fe473de5bc2
Autor:
Amit Sharma, Alison Slaughter, Nivedita Jena, Lei Feng, Jacques J Kessl, Hind J Fadel, Nirav Malani, Frances Male, Li Wu, Eric Poeschla, Frederic D Bushman, James R Fuchs, Mamuka Kvaratskhelia
Publikováno v:
PLoS Pathogens, Vol 10, Iss 5, p e1004171 (2014)
The quinoline-based allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are promising candidates for clinically useful antiviral agents. Studies using these compounds have highlighted the role of IN in both early and late stages of virus replication
Externí odkaz:
https://doaj.org/article/7ceda5ee2d6f497c8ecf7da87f9b4d83
Autor:
Anne M Meehan, Dyana T Saenz, Rebekah Guevera, James H Morrison, Mary Peretz, Hind J Fadel, Masakazu Hamada, Jan van Deursen, Eric M Poeschla
Publikováno v:
PLoS Pathogens, Vol 10, Iss 2, p e1003969 (2014)
The large nucleoporin Nup358/RanBP2 forms eight filaments that project from the nuclear pore into the cytoplasm where they function as docking platforms for nucleocytoplasmic transport receptors. RNAi screens have implicated Nup358 in the HIV-1 life
Externí odkaz:
https://doaj.org/article/e1497fe668114b55906abc20163c1e2b
Autor:
Allison Ballandras-Colas, Vidya Chivukula, Dominika T. Gruszka, Zelin Shan, Parmit K. Singh, Valerie E. Pye, Rebecca K. McLean, Gregory J. Bedwell, Wen Li, Andrea Nans, Nicola J. Cook, Hind J. Fadel, Eric M. Poeschla, David J. Griffiths, Javier Vargas, Ian A. Taylor, Dmitry Lyumkis, Hasan Yardimci, Alan N. Engelman, Peter Cherepanov
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The authors determined high-resolution cryo-EM structures of the lentiviral intasome — the nucleoprotein complex that inserts viral DNA into a host chromosome — and show that the architecture comprising 16 integrase subunits is critical for its f
Externí odkaz:
https://doaj.org/article/38b768c566d24b6c8e369c087cb41667
Autor:
Parmit Kumar Singh, Wen Li, Gregory J. Bedwell, Hind J. Fadel, Eric M. Poeschla, Alan N. Engelman
Publikováno v:
Viruses, Vol 14, Iss 9, p 1883 (2022)
Allosteric integrase (IN) inhibitors (ALLINIs), which are promising preclinical compounds that engage the lens epithelium-derived growth factor (LEDGF)/p75 binding site on IN, can inhibit different aspects of human immunodeficiency virus 1 (HIV-1) re
Externí odkaz:
https://doaj.org/article/7577eca5ddbd4533ae9c76d4eb51dcf4
Autor:
Wen Li, Parmit K. Singh, Gregory A. Sowd, Gregory J. Bedwell, Sooin Jang, Vasudevan Achuthan, Amarachi V. Oleru, Doris Wong, Hind J. Fadel, KyeongEun Lee, Vineet N. KewalRamani, Eric M. Poeschla, Alon Herschhorn, Alan N. Engelman
Publikováno v:
mBio, Vol 11, Iss 5 (2020)
ABSTRACT Lentiviral DNA integration favors transcriptionally active chromatin. We previously showed that the interaction of human immunodeficiency virus type 1 (HIV-1) capsid with cleavage and polyadenylation specificity factor 6 (CPSF6) localizes vi
Externí odkaz:
https://doaj.org/article/7f4eaeb2c24147479988497d78e83da7
Autor:
Daniel C. DeSimone, Philip R. Heaton, Brian A. Neff, Linda N. Dao, Nancy L. Wengenack, Hind J. Fadel
Publikováno v:
Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, Vol 8, Iss , Pp 13-15 (2017)
Chronic otitis externa due to Mycobacterium tuberculosis complex is extremely rare and very few cases have been presented in the medical literature. We report here the case of an immunocompetent 68-year-old male with chronic auricular drainage, otalg
Externí odkaz:
https://doaj.org/article/fa87b4fc72e142e4bdeb35e8619b6c76
Publikováno v:
Viruses, Vol 4, Iss 1, Pp 184-199 (2012)
Single cycle reporter viruses that preserve the majority of the HIV-1 genome, long terminal repeat-promoted transcription and Rev-dependent structural protein expression are useful for investigating the viral life cycle. Reporter viruses that encode
Externí odkaz:
https://doaj.org/article/ace214203edb4a6e9528dd9d8be53431
Publikováno v:
Infection and Drug Resistance
Kanika Sehgal,1 Hind J Fadel,2 Aaron J Tande,2 Darrell S Pardi,1 Sahil Khanna1 1Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA; 2Division of Infectious Diseases, Mayo Clinic, Rochester, MN, USACorrespondence: Sahil Khann