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pro vyhledávání: '"Hind, Abdalaal"'
Autor:
Jessica M A Blair, Pauline Siasat, Helen E McNeil, Abigail Colclough, Vito Ricci, Amelia J Lawler, Hind Abdalaal, Michelle M C Buckner, Alison Baylay, Stephen J Busby, Laura J V Piddock
Publikováno v:
Journal of Antimicrobial Chemotherapy. 78:133-140
Background Resistance nodulation division (RND) family efflux pumps, including the major pump AcrAB-TolC, are important mediators of intrinsic and evolved antibiotic resistance. Expression of these pumps is carefully controlled by a network of regula
Publikováno v:
Molecular Biology and Evolution
When new genes evolve through modification of existing genes, there are often tradeoffs between the new and original functions, making gene duplication and amplification necessary to buffer deleterious effects on the original function. We have used e
Autor:
Joakim Näsvall, Hind Abdalaal
Publikováno v:
Access Microbiology. 1
The project aims to generate a library of laboratory orthologous genes for studying evolvability. In this study, we have taken one of histidine biosynthetic genes hisA from Salmonella enterica through alternating rounds of weak selection (simulated b