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Investigating the interaction of McN-A-343 with the M1 muscarinic receptor using its nitrogen mustard derivative and ACh mustard

Autor: Hinako Suga, Frederick J. Ehlert, Katherine W. Figueroa

Publikováno v: British Journal of Pharmacology. 160:1534-1549

Background and purpose: We investigated how McN-A-343 inhibited the alkylation of the M1 muscarinic receptor by its nitrogen mustard derivative and that of ACh to identify whether it interacts allosterically or orthosterically. Experimental approach:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::37a94bbf4c27fb8baa6d436e8f92538e
https://doi.org/10.1111/j.1476-5381.2010.00810.x

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Investigating the interaction of McN-A-343 with the M2 muscarinic receptor using its nitrogen mustard derivative

Autor: Hinako Suga, Frederick J. Ehlert

Publikováno v: Biochemical Pharmacology. 79:1025-1035

We investigated whether the aziridinium ion formed from a nitrogen mustard derivative (4-[(2-bromoethyl)methyl-amino]-2-butynyl N-(3-chlorophenyl)carbamate; BR384) structurally related to McN-A-343 (4-(trimethyl-amino)-2-butynyl N-(3-chlorophenyl)car

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ce0ea0c4c0a5aadfe4162f64e6a459
https://doi.org/10.1016/j.bcp.2009.11.005

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Ligand screening system using fusion proteins of G protein-coupled receptors with G protein α subunits

Autor: Hinako Suga, Tatsuya Haga

Publikováno v: Neurochemistry International. 51:140-164

G protein-coupled receptors (GPCRs) constitute one of the largest families of genes in the human genome, and are the largest targets for drug development. Although a large number of GPCR genes have recently been identified, ligands have not yet been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::660aeb4f35e2a24958ec65da38e4b67e
https://doi.org/10.1016/j.neuint.2007.06.006

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Gene Expression of Taste Receptor in Normal Persons and Taste Disorder Persons

Autor: Akiko, MORI, Naoko, YAMADA, Chikako, YOSHIDA, Kyoichi, TAKAO, Fumihiko, KOIKE, Hiromi, KAZAMA, Hinako, SUGA, Tetsuya, TAKAO

Publikováno v: 學苑 = GAKUEN. 782:57-63

RT-PCR法を用いて,葉状乳頭における味覚受容体の発現を検討した。すなわち葉状乳頭部から擦過法により取得した組織を使用し,味覚受容体候補であるTHTRファミリー(THTRs)およびT2Rファミリ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=jairo_______::2da5d2c4be3277dda68494991e1d0e00
http://id.nii.ac.jp/1203/00003751/

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Screening of Taste Receptors (Part 2) : Responsiveness for Some Taste Stimulants of THTR5 That Originally Cloned from the Papillae

Autor: Akiko, MORI, Tomoko, KONISHI, Yuka, YOSHIDA, Kyoichi, TAKAO, Hinako, SUGA, Tetsuya, TAKAO

Publikováno v: 學苑 = GAKUEN. 770:95-100

Gタンパク質共役受容体THTR5をCHO細胞に導入し,呈味物質への応答性を検討した。THTR5クローンにおいてはGlucose, Fructose, Sorbitol, Arginine, Denatonium benzoate, Guanosin 5monophosphate disodium salt, Inosin 5'mono

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=jairo_______::915f6eb669ca63f8f024c41f23423af1
http://id.nii.ac.jp/1203/00003486/

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Stimulation of Increases in Intracellular Calcium and Prostaglandin E2 Generation in Chinese Hamster Ovary Cells Expressing Receptor-G 16 Fusion Proteins

Autor: Michiko Okamura, Tatsuya Haga, Kyoichi Takao, Hinako Suga, Shigeki Takeda, Kazuhiko Tatemoto

Publikováno v: Journal of Biochemistry. 135:605-613

We examined whether fusion proteins of G protein-coupled receptors with the alpha subunit of G(16) (Galpha(16)) could activate downstream signals. We expressed fusion proteins of G(i)-coupled receptors, i.e. CX(3)C chemokine receptor 1 (CX(3)CR1) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6d08b7aafd82323f84ce1dc403fe99e
https://doi.org/10.1093/jb/mvh058

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Screening of taste receptors : Responsiveness for some tastants of GPR14 that originally cloned from the papillae

Autor: Yuka, Yoshida, Mamiko, Sakai, Kyoichi, Takao, Hinako, Suga, Tetsuya, Takao

Publikováno v: 學苑 = GAKUEN. 758:54-61

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=jairo_______::3f4384c5f227169aec7577d7c357f63c
http://id.nii.ac.jp/1203/00003207/

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Effects of asparagine mutagenesis of conserved aspartic acids in helix 2 (D2.50) and 3 (D3.32) of M1-M4 muscarinic receptors on the irreversible binding of nitrogen mustard analogs of acetylcholine and McN-A-343

Autor: Frederick J. Ehlert, Hinako Suga

Publikováno v: Biochemistry. 52(29)

We investigated how asparagine mutagenesis of conserved aspartic acids in helix two (D2.50) and three (D3.32) of M1 – M4 muscarinic receptors alters the irreversible binding of acetylcholine mustard and BR384 (4-[(2-bromoethyl)methyl-amino]-2-butyn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::170b191b985e7754f5c6df8a2f177b38
https://pubmed.ncbi.nlm.nih.gov/23826889

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Quantifying agonist activity at G protein-coupled receptors

Autor: Hinako Suga, Frederick J. Ehlert, Michael T. Griffin

Publikováno v: Journal of visualized experiments : JoVE. (58)

When an agonist activates a population of G protein-coupled receptors (GPCRs), it elicits a signaling pathway that culminates in the response of the cell or tissue. This process can be analyzed at the level of a single receptor, a population of recep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106fdac23aa55a6868c7037b9e1c351b
https://pubmed.ncbi.nlm.nih.gov/22231636

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