Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Hina Sarwath"'
Autor:
Anna Halama, Shaza Zaghlool, Gaurav Thareja, Sara Kader, Wadha Al Muftah, Marjonneke Mook-Kanamori, Hina Sarwath, Yasmin Ali Mohamoud, Nisha Stephan, Sabine Ameling, Maja Pucic Baković, Jan Krumsiek, Cornelia Prehn, Jerzy Adamski, Jochen M. Schwenk, Nele Friedrich, Uwe Völker, Manfred Wuhrer, Gordan Lauc, S. Hani Najafi-Shoushtari, Joel A. Malek, Johannes Graumann, Dennis Mook-Kanamori, Frank Schmidt, Karsten Suhre
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract In-depth multiomic phenotyping provides molecular insights into complex physiological processes and their pathologies. Here, we report on integrating 18 diverse deep molecular phenotyping (omics-) technologies applied to urine, blood, and sa
Externí odkaz:
https://doaj.org/article/711d016111244d3c97a32572e4aba254
Autor:
Karsten Suhre, Guhan Ram Venkataraman, Harendra Guturu, Anna Halama, Nisha Stephan, Gaurav Thareja, Hina Sarwath, Khatereh Motamedchaboki, Margaret K. R. Donovan, Asim Siddiqui, Serafim Batzoglou, Frank Schmidt
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Proteogenomics studies generate hypotheses on protein function and provide genetic evidence for drug target prioritization. Most previous work has been conducted using affinity-based proteomics approaches. These technologies face challenges,
Externí odkaz:
https://doaj.org/article/dc36d59054594f129b87e7c28a9978c6
Autor:
Frank Schmidt, Houari B. Abdesselem, Karsten Suhre, Nishant N. Vaikath, Muhammad U. Sohail, Maryam Al-Nesf, Ilham Bensmail, Fathima Mashod, Hina Sarwath, Joerg Bernhardt, Stephanie Schaefer-Ramadan, Ti-Myen Tan, Priscilla E. Morris, Edward J. Schenck, David Price, Vidya Mohamed-Ali, Mohammed Al-Maadheed, Abdelilah Arredouani, Julie Decock, Jonathan M. Blackburn, Augustine M. K. Choi, Omar M. El-Agnaf
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Background: Coronavirus disease (COVID-19) manifests many clinical symptoms, including an exacerbated immune response and cytokine storm. Autoantibodies in COVID-19 may have severe prodromal effects that are poorly understood. The interaction between
Externí odkaz:
https://doaj.org/article/cafc2cc0758a400281587d6a1c37112f
Autor:
Mustafa Buyukozkan, Sergio Alvarez-Mulett, Alexandra C. Racanelli, Frank Schmidt, Richa Batra, Katherine L. Hoffman, Hina Sarwath, Rudolf Engelke, Luis Gomez-Escobar, Will Simmons, Elisa Benedetti, Kelsey Chetnik, Guoan Zhang, Edward Schenck, Karsten Suhre, Justin J. Choi, Zhen Zhao, Sabrina Racine-Brzostek, He S. Yang, Mary E. Choi, Augustine M.K. Choi, Soo Jung Cho, Jan Krumsiek
Publikováno v:
iScience, Vol 25, Iss 7, Pp 104612- (2022)
Summary: The coronavirus disease-19 (COVID-19) pandemic has ravaged global healthcare with previously unseen levels of morbidity and mortality. In this study, we performed large-scale integrative multi-omics analyses of serum obtained from COVID-19 p
Externí odkaz:
https://doaj.org/article/a62f77fb3df5497ebf2ec8150d80ce78
Autor:
Rudolf Engelke, Sami Ouanes, Suhaila Ghuloum, Rifka Chamali, Nancy Kiwan, Hina Sarwath, Frank Schmidt, Karsten Suhre, Hassen Al-Amin
Publikováno v:
Frontiers in Psychiatry, Vol 13 (2022)
BackgroundSchizophrenia (SZ) and bipolar disorder (BD) share many features: overlap in mood and psychotic symptoms, common genetic predisposition, treatment with antipsychotics (APs), and similar metabolic comorbidities. The pathophysiology of both i
Externí odkaz:
https://doaj.org/article/4c7edcdb572d4b248b7e336a699f5f6e
Autor:
Shaza B. Zaghlool, Brigitte Kühnel, Mohamed A. Elhadad, Sara Kader, Anna Halama, Gaurav Thareja, Rudolf Engelke, Hina Sarwath, Eman K. Al-Dous, Yasmin A. Mohamoud, Thomas Meitinger, Rory Wilson, Konstantin Strauch, Annette Peters, Dennis O. Mook-Kanamori, Johannes Graumann, Joel A. Malek, Christian Gieger, Melanie Waldenberger, Karsten Suhre
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
DNA methylation is associated with complex traits and the expression of genes and proteins. Here, Zaghlool et al. perform epigenome-wide association studies for 1,123 plasma proteins, replicate obtained protein (p)QTMs in an independent cohort and fi
Externí odkaz:
https://doaj.org/article/0823a74153c147a29321e71963cf2a18
Autor:
Karsten Suhre, Hina Sarwath, Rudolf Engelke, Muhammad Umar Sohail, Soo Jung Cho, William Whalen, Sergio Alvarez-Mulett, Jan Krumsiek, Augustine M. K. Choi, Frank Schmidt
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Multiple studies have investigated the role of blood circulating proteins in COVID-19 disease using the Olink affinity proteomics platform. However, study inclusion criteria and sample collection conditions varied between studies, leading to sometime
Externí odkaz:
https://doaj.org/article/4225c005d4cc4dfe8655d4d9aa57ed52
Autor:
Hina Sarwath, Devendra Bansal, Nazik Elmalaika Husain, Mahmoud Mohamed, Ali A. Sultan, Shahinaz Bedri
Publikováno v:
Infectious Agents and Cancer, Vol 12, Iss 1, Pp 1-8 (2017)
Abstract Background Cervical cancer is the fourth most common cancer in women worldwide with highest incidence reported in Eastern Africa in 2012. The primary goal of this study was to study the expression of p16INK4a in squamous cell carcinoma (SCC)
Externí odkaz:
https://doaj.org/article/568a5569f1254e74b862f93adcb0e726
Autor:
Karsten Suhre, Matthias Arnold, Aditya Mukund Bhagwat, Richard J. Cotton, Rudolf Engelke, Johannes Raffler, Hina Sarwath, Gaurav Thareja, Annika Wahl, Robert Kirk DeLisle, Larry Gold, Marija Pezer, Gordan Lauc, Mohammed A. El-Din Selim, Dennis O. Mook-Kanamori, Eman K. Al-Dous, Yasmin A. Mohamoud, Joel Malek, Konstantin Strauch, Harald Grallert, Annette Peters, Gabi Kastenmüller, Christian Gieger, Johannes Graumann
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Individual genetic variation can affect the levels of protein in blood, but detailed data sets linking these two types of data are rare. Here, the authors carry out a genome-wide association study of levels of over a thousand different proteins, and
Externí odkaz:
https://doaj.org/article/8795d9d74e404676970c345596c0741f
Autor:
Karsten Suhre, Matthias Arnold, Aditya Mukund Bhagwat, Richard J. Cotton, Rudolf Engelke, Johannes Raffler, Hina Sarwath, Gaurav Thareja, Annika Wahl, Robert Kirk DeLisle, Larry Gold, Marija Pezer, Gordan Lauc, Mohammed A. El-Din Selim, Dennis O. Mook-Kanamori, Eman K. Al-Dous, Yasmin A. Mohamoud, Joel Malek, Konstantin Strauch, Harald Grallert, Annette Peters, Gabi Kastenmüller, Christian Gieger, Johannes Graumann
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)
Nature Communications 8: Article number: 14357 (2017); Published 27 February 2017; Updated 11 April 2017 The original version of the Supplementary Information attached to this Article did not include Supplementary Note 1 The HTML has now been updated
Externí odkaz:
https://doaj.org/article/c1e1c89ac28d4d7f99eabe2e099433bd