Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Hin-Chor Wong"'
Publikováno v:
Journal of Medicinal Chemistry. 33:1892-1898
A series of 2,6-disubstituted 4-(2-arylethenyl)phenols with potent human neutrophil 5-lipoxygenase (5-LO) inhibiting activity (IC 50 s in the 10 −7 M range) and weaker human platelet cyclooxygenase (CO) inhibiting activity (IC 50 s in the 10 −6 M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dabb742939bf04e8158da3e407aebf91
https://doi.org/10.1021/jm00169a010
https://doi.org/10.1021/jm00169a010
Autor:
Sorcek Ronald J, Simon J. Coutts, L. Churchill, Eva David, Mcneil Daniel W, Gunter Trummlitz, Hin-Chor Wong, Peter M. Grob, Ian Potocki, Hans Meier, Matt Aaron Tschantz, Wolfhard Engel, Lazer Edward S, Miao Clara K, A. G. Graham, Terence A. Kelly, Charles L. Cywin, Maryann Hoermann, Zhaoxing Meng, Roger J. Snow
Publikováno v:
Journal of medicinal chemistry. 40(6)
Meloxicam (5), an NSAID in the enol-carboxamide class, was developed on the basis of its antiinflammatory activity and relative safety in animal models. In subsequent screening in microsomal assays using human COX-1 and COX-2, we discovered that it p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50186f66868fad80b86b655e901a13d8
https://pubmed.ncbi.nlm.nih.gov/9083488
https://pubmed.ncbi.nlm.nih.gov/9083488
Autor:
A. Gilman, Hin Chor Wong, Miao Clara K, Denice M. Spero, Kollol Pal, Mark L. Behnke, A. G. Graham, J. M. Watrous, Sorcek Ronald J, Lazer Edward S
Publikováno v:
Journal of medicinal chemistry. 37(7)
A series of benzoxazolamine and benzothiazolamine analogs that inhibit leukotriene (LT) biosynthesis are described. The initial lead, (S)-N-(benzothiazol-2- yl)phenylalanine ethyl ester (5a), was discovered in a screening program for inhibition of Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf4b4c63e97b414e943b72649e4ef842
https://pubmed.ncbi.nlm.nih.gov/8151618
https://pubmed.ncbi.nlm.nih.gov/8151618
Autor:
Thelma LeClerq, Hin Chor Wong, Kurt Freter, Ernest Cullen, Reinhold Becker, Genus J. Possanza
Publikováno v:
Journal of medicinal chemistry. 35(2)
A series of benzobisthiazoles were screened for antiinflammatory activity in the carrageenan paw edema and adjuvant arthritis tests. Compound 26, 2,6-bis(N,N-diethylamino)benzo[1,2-d:5,4-d']bisthiazole, was found to inhibit the swelling of the uninje
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7bf6cfd82de2e13845a4714c42399fe
https://pubmed.ncbi.nlm.nih.gov/1732553
https://pubmed.ncbi.nlm.nih.gov/1732553
Publikováno v:
Journal of Medicinal Chemistry. 32:100-104
A series of 2,6-di-tert-butyl-4-(2-arylethenyl)phenols was prepared and examined for their ability to inhibit cyclooxygenase and 5-lipoxygenase in vitro and developing adjuvant arthritis in vivo in the rat. Structure-activity relationships are discus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b756c9c7d7016cf58756eb83f3f03d7a
https://doi.org/10.1021/jm00121a021
https://doi.org/10.1021/jm00121a021
Publikováno v:
Synthesis. 1981:394-396
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25e740d46c562e31b12836f151cdb21f
https://doi.org/10.1055/s-1981-29466
https://doi.org/10.1055/s-1981-29466
Autor:
Durgant, Jean-Marc, Vogel, Pierre
Publikováno v:
Helvetica Chimica Acta; 1993, Vol. 76 Issue 1, p222-240, 19p
Publikováno v:
Helvetica Chimica Acta; 1984, Vol. 67 Issue 7, p1998-2008, 11p
Autor:
Vincent J. Merluzzi, Julian Adams
Perspectives on Anti-Inflammatory Drugs Inflammation is a very complicated process of interrelated events and cas cades that does not allow for an easily defined, focused attack for drug discovery. It is evident from years of research and developme
