Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Hin Chor Wong"'
Publikováno v:
Journal of Medicinal Chemistry. 33:1892-1898
A series of 2,6-disubstituted 4-(2-arylethenyl)phenols with potent human neutrophil 5-lipoxygenase (5-LO) inhibiting activity (IC 50 s in the 10 −7 M range) and weaker human platelet cyclooxygenase (CO) inhibiting activity (IC 50 s in the 10 −6 M
Autor:
Sorcek Ronald J, Simon J. Coutts, L. Churchill, Eva David, Mcneil Daniel W, Gunter Trummlitz, Hin-Chor Wong, Peter M. Grob, Ian Potocki, Hans Meier, Matt Aaron Tschantz, Wolfhard Engel, Lazer Edward S, Miao Clara K, A. G. Graham, Terence A. Kelly, Charles L. Cywin, Maryann Hoermann, Zhaoxing Meng, Roger J. Snow
Publikováno v:
Journal of medicinal chemistry. 40(6)
Meloxicam (5), an NSAID in the enol-carboxamide class, was developed on the basis of its antiinflammatory activity and relative safety in animal models. In subsequent screening in microsomal assays using human COX-1 and COX-2, we discovered that it p
Autor:
A. Gilman, Hin Chor Wong, Miao Clara K, Denice M. Spero, Kollol Pal, Mark L. Behnke, A. G. Graham, J. M. Watrous, Sorcek Ronald J, Lazer Edward S
Publikováno v:
Journal of medicinal chemistry. 37(7)
A series of benzoxazolamine and benzothiazolamine analogs that inhibit leukotriene (LT) biosynthesis are described. The initial lead, (S)-N-(benzothiazol-2- yl)phenylalanine ethyl ester (5a), was discovered in a screening program for inhibition of Ca
Autor:
Thelma LeClerq, Hin Chor Wong, Kurt Freter, Ernest Cullen, Reinhold Becker, Genus J. Possanza
Publikováno v:
Journal of medicinal chemistry. 35(2)
A series of benzobisthiazoles were screened for antiinflammatory activity in the carrageenan paw edema and adjuvant arthritis tests. Compound 26, 2,6-bis(N,N-diethylamino)benzo[1,2-d:5,4-d']bisthiazole, was found to inhibit the swelling of the uninje
Publikováno v:
Journal of Medicinal Chemistry. 32:100-104
A series of 2,6-di-tert-butyl-4-(2-arylethenyl)phenols was prepared and examined for their ability to inhibit cyclooxygenase and 5-lipoxygenase in vitro and developing adjuvant arthritis in vivo in the rat. Structure-activity relationships are discus
Publikováno v:
Synthesis. 1981:394-396