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Akademický článek

Non-Nucleoside Reverse Transcriptase Inhibitors Join Forces with Integrase Inhibitors to Combat HIV.

Autor: Himmel DM; Himmel Sci Med Com, L.L.C., Bala Cynwyd, PA 19004, USA., Arnold E; Center for Advanced Biotechnology and Medicine (CABM), Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA.

Publikováno v: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2020 Jun 11; Vol. 13 (6). Date of Electronic Publication: 2020 Jun 11.

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Akademický článek

Structure of a dihydroxycoumarin active-site inhibitor in complex with the RNase H domain of HIV-1 reverse transcriptase and structure-activity analysis of inhibitor analogs.

Autor: Himmel DM; Center for Advanced Biotechnology and Medicine and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854-5627, USA. Electronic address: himmel@cabm.rutgers.edu., Myshakina NS; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA. Electronic address: nsm11@pitt.edu., Ilina T; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA. Electronic address: tai4@pitt.edu., Van Ry A; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA. Electronic address: avanry86@hotmail.com., Ho WC; Center for Advanced Biotechnology and Medicine and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854-5627, USA. Electronic address: who@cabm.rutgers.edu., Parniak MA; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA. Electronic address: map167@pitt.edu., Arnold E; Center for Advanced Biotechnology and Medicine and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854-5627, USA. Electronic address: arnold@cabm.rutgers.edu.

Publikováno v: Journal of molecular biology [J Mol Biol] 2014 Jul 15; Vol. 426 (14), pp. 2617-31. Date of Electronic Publication: 2014 May 17.

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Akademický článek

Identification of alternative binding sites for inhibitors of HIV-1 ribonuclease H through comparative analysis of virtual enrichment studies.

Autor: Felts AK; BioMaPS Institute for Quantitative Biology, Rutgers University, Piscataway, New Jersey 08854, USA. felts@lutece.rutgers.edu, Labarge K, Bauman JD, Patel DV, Himmel DM, Arnold E, Parniak MA, Levy RM

Publikováno v: Journal of chemical information and modeling [J Chem Inf Model] 2011 Aug 22; Vol. 51 (8), pp. 1986-98. Date of Electronic Publication: 2011 Jul 26.

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Akademický článek

Synthesis, activity, and structural analysis of novel α-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H.

Autor: Chung S; RT Biochemistry Section, HIV Drug Resistance Program, National Cancer Institute-Frederick, Frederick, Maryland 21702, United States., Himmel DM, Jiang JK, Wojtak K, Bauman JD, Rausch JW, Wilson JA, Beutler JA, Thomas CJ, Arnold E, Le Grice SF

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2011 Jul 14; Vol. 54 (13), pp. 4462-73. Date of Electronic Publication: 2011 Jun 02.

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Akademický článek

Structure of HIV-1 reverse transcriptase with the inhibitor beta-Thujaplicinol bound at the RNase H active site.

Autor: Himmel DM; Center for Advanced Biotechnology and Medicine and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854-8021, USA., Maegley KA; Pfizer Global Research and Development, La Jolla Laboratories, San Diego, CA 92121, USA., Pauly TA; Pfizer Global Research and Development, La Jolla Laboratories, San Diego, CA 92121, USA., Bauman JD; Center for Advanced Biotechnology and Medicine and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854-8021, USA., Das K; Center for Advanced Biotechnology and Medicine and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854-8021, USA., Dharia C; Center for Advanced Biotechnology and Medicine and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854-8021, USA., Clark AD Jr; Center for Advanced Biotechnology and Medicine and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854-8021, USA., Ryan K; Pfizer Global Research and Development, La Jolla Laboratories, San Diego, CA 92121, USA., Hickey MJ; Pfizer Global Research and Development, La Jolla Laboratories, San Diego, CA 92121, USA., Love RA; Pfizer Global Research and Development, La Jolla Laboratories, San Diego, CA 92121, USA., Hughes SH; HIV Drug Resistance Program, NCI-Frederick, Frederick, MD 21702-1201, USA., Bergqvist S; Pfizer Global Research and Development, La Jolla Laboratories, San Diego, CA 92121, USA., Arnold E; Center for Advanced Biotechnology and Medicine and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854-8021, USA. Electronic address: arnold@cabm.rutgers.edu.

Publikováno v: Structure (London, England : 1993) [Structure] 2009 Dec 09; Vol. 17 (12), pp. 1625-1635.

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