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Secretion of the fungal toxin candidalysin is dependent on conserved precursor peptide sequences.

Autor: Müller R; Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute (HKI), Jena, Germany., König A; Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute (HKI), Jena, Germany.; Institute of Microbiology, Friedrich Schiller University, Jena, Germany., Groth S; Division of Biophysics, Research Center Borstel, Leibniz Lung Center, Borstel, Germany., Zarnowski R; Department of Medicine, Section of Infectious Diseases, University of Wisconsin-Madison, Madison, WI, USA., Visser C; Institute of Microbiology, Friedrich Schiller University, Jena, Germany.; Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute (HKI), Jena, Germany., Handrianz T; Division of Biophysics, Research Center Borstel, Leibniz Lung Center, Borstel, Germany., Maufrais C; Institut Pasteur, Université Paris Cité, Bioinformatics and Biostatistics Hub, Paris, France.; Institut Pasteur, Université Paris Cité, Unité Biologie et Pathogénicité Fongiques, Paris, France., Krüger T; Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute (HKI), Jena, Germany., Himmel M; Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute (HKI), Jena, Germany., Lee S; Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, London, UK., Priest EL; Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, London, UK., Yildirim D; Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute (HKI), Jena, Germany., Richardson JP; Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, London, UK., Blango MG; RNA Biology of Fungal Infections, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute (HKI), Jena, Germany., Bougnoux ME; Institut Pasteur, Université Paris Cité, Unité Biologie et Pathogénicité Fongiques, Paris, France.; Unité de Parasitologie-Mycologie, Service de Microbiologie Clinique, Hôpital Necker-Enfants-Malades, Assistance Publique des Hôpitaux de Paris (APHP), Paris, France., Kniemeyer O; Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute (HKI), Jena, Germany., d'Enfert C; Institut Pasteur, Université Paris Cité, Unité Biologie et Pathogénicité Fongiques, Paris, France., Brakhage AA; Institute of Microbiology, Friedrich Schiller University, Jena, Germany.; Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute (HKI), Jena, Germany.; Cluster of Excellence Balance of the Microverse, Friedrich Schiller University Jena, Jena, Germany., Andes DR; Department of Medicine, Section of Infectious Diseases, University of Wisconsin-Madison, Madison, WI, USA., Trümper V; Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute (HKI), Jena, Germany., Nehls C; Division of Biophysics, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.; Kiel Nano, Surface and Interface Science KiNSIS, Kiel University, Kiel, Germany., Kasper L; Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute (HKI), Jena, Germany., Mogavero S; Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute (HKI), Jena, Germany., Gutsmann T; Division of Biophysics, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.; Kiel Nano, Surface and Interface Science KiNSIS, Kiel University, Kiel, Germany., Naglik JR; Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, London, UK., Allert S; Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute (HKI), Jena, Germany. stefanie.allert@leibniz-hki.de., Hube B; Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute (HKI), Jena, Germany. bernhard.hube@leibniz-hki.de.; Institute of Microbiology, Friedrich Schiller University, Jena, Germany. bernhard.hube@leibniz-hki.de.; Cluster of Excellence Balance of the Microverse, Friedrich Schiller University Jena, Jena, Germany. bernhard.hube@leibniz-hki.de.

Publikováno v: Nature microbiology [Nat Microbiol] 2024 Mar; Vol. 9 (3), pp. 669-683. Date of Electronic Publication: 2024 Feb 22.