Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Himangshu Sonowal"'
Publikováno v:
HemaSphere, Vol 7, p e30384d0 (2023)
Externí odkaz:
https://doaj.org/article/0057d634984d4c88a3c36d50fbcdf1ef
Publikováno v:
PLoS ONE, Vol 18, Iss 3, p e0277003 (2023)
Luxeptinib (LUX) is a novel oral kinase inhibitor that inhibits FLT3 and also interferes with signaling from the BCR and cell surface TLRs, as well as activation of the NLRP3 inflammasome. Ongoing clinical trials are testing its activity in patients
Externí odkaz:
https://doaj.org/article/30ec601fe6d34800af63498e592e7535
Autor:
Himangshu Sonowal, Pabitra B. Pal, Jian-Jun Wen, Sanjay Awasthi, Kota V. Ramana, Satish K. Srivastava
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Anthracycline drugs such as doxorubicin (DOX) and daunorubicin remain some of the most active wide-spectrum and cost-effective drugs in cancer therapy. However, colorectal cancer (CRC) cells are inherently resistant to anthracyclines which a
Externí odkaz:
https://doaj.org/article/6f2463b6cece423cb821de61b7c4f45e
Publikováno v:
Journal of Diabetes Research, Vol 2017 (2017)
We have shown earlier that pretreatment of cultured cells with aldose reductase (AR) inhibitors prevents hyperglycemia-induced mitogenic and proinflammatory responses. However, the effects of AR inhibitors on Nrf2-mediated anti-inflammatory responses
Externí odkaz:
https://doaj.org/article/341a76c839554e3faff09b8a761a7d5f
Autor:
Himangshu Sonowal, Kota V. Ramana
Publikováno v:
Current Medicinal Chemistry. 28:3683-3712
Aldose Reductase (AR) is an enzyme that converts glucose to sorbitol during the polyol pathway of glucose metabolism. AR has been shown to be involved in the development of secondary diabetic complications due to its involvement in causing osmotic as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c51265cb8396640110a3f3374c824f25
https://doi.org/10.2174/0929867327666201027152737
https://doi.org/10.2174/0929867327666201027152737
Publikováno v:
J Mol Endocrinol
Although hyperglycemia-mediated death and dysfunction of endothelial cells have been reported to be a major cause of diabetes associated vascular complications, the mechanisms through which hyperglycemia cause endothelial dysfunction is not well unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f6b1326c03c692573f9209086a1dd1
https://doi.org/10.1530/jme-19-0080
https://doi.org/10.1530/jme-19-0080
Autor:
Kota V. Ramana, Himangshu Sonowal
Publikováno v:
Toxicol In Vitro
2'-Hydroxyflavanone (2-HF) is a natural flavonoid isolated from citrus fruits. Multiple studies have demonstrated that 2-HF with its anti-proliferative and pro-apoptotic effects prevent the growth of various cancers. Although 2-HF is a well known ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d48e783d700b303e770d59a9aff4556
https://europepmc.org/articles/PMC7572836/
https://europepmc.org/articles/PMC7572836/
Publikováno v:
Oxidative Stress in Lung Diseases ISBN: 9789811384127
Asthma and chronic obstructive pulmonary disease (COPD) are the major lung inflammatory diseases that are characterized by expiratory airflow limitation, chronic inflammation, and structural and functional changes of airways. Although steroids are mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cf573e4e5db7b6ddec67753eeca3a36
https://doi.org/10.1007/978-981-13-8413-4_12
https://doi.org/10.1007/978-981-13-8413-4_12
Lipid aldehydes abundantly found in the nutritional and dietary fats, environmental pollutants, and endogenously generated in the body play a critical role in human health and diseases. The lipid aldehydes are very reactive and form conjugates with c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::522ab7ba3fc5a80e93e52e5a1bf643bc
https://doi.org/10.1016/b978-0-12-811297-7.00032-9
https://doi.org/10.1016/b978-0-12-811297-7.00032-9
Publikováno v:
European Journal of Pharmacology. 895:173884
We have recently demonstrated that aldose reductase (AR) inhibitor; fidarestat prevents doxorubicin (Dox)-induced cardiotoxic side effects and inflammation in vitro and in vivo. However, the effect of fidarestat and its combination with Dox on immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24073bf4e789b40d845eb590715070ac
https://doi.org/10.1016/j.ejphar.2021.173884
https://doi.org/10.1016/j.ejphar.2021.173884