Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Himadri, Samanta"'
Publikováno v:
The Journal of Association of Chest Physicians, Vol 5, Iss 1, Pp 60-61 (2017)
Externí odkaz:
https://doaj.org/article/b16ac993f7a842ef909f8ecd1fc36a4c
Autor:
Alicia Regueiro-Ren, Jacob J. Swidorski, Zheng Liu, Yan Chen, Ny Sin, Sing-Yuen Sit, Jie Chen, Brian L. Venables, Juliang Zhu, Beata Nowicka-Sans, Tricia Protack, Zeyu Lin, Brian Terry, Himadri Samanta, Sharon Zhang, Zhufang Li, John Easter, Brett R. Beno, Vinod Arora, Xiaohua S. Huang, Sandhya Rahematpura, Dawn D. Parker, Roy Haskell, Kenneth S. Santone, Mark I. Cockett, Mark Krystal, Nicholas A. Meanwell, Susan Jenkins, Umesh Hanumegowda, Ira B. Dicker
Publikováno v:
Journal of Medicinal Chemistry. 61:7289-7313
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c3666e9905493812ef4d0ec28c2e176
https://doi.org/10.1021/acs.jmedchem.8b00854
https://doi.org/10.1021/acs.jmedchem.8b00854
Autor:
Michael A. Walker, Kevin M. Peese, Volodymyr Gali, Himadri Samanta, Manoj Patel, Ming Zheng, David R. Langley, B. Narasimhulu Naidu, Chen Li, Tricia Protack, Ira B. Dicker, Susan Jenkins, Zeyu Lin, Nicholas A. Meanwell, Brian Terry, Mark Krystal
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(3)
A series of heterocyclic pyrimidinedione-based HIV-1 integrase inhibitors was prepared and screened for activity against purified integrase enzyme and/or viruses modified with the following mutations within integrase: Q148R, Q148H/G140S and N155H. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6644899b291853ca696e0ed3c557fcad
https://pubmed.ncbi.nlm.nih.gov/31761656
https://pubmed.ncbi.nlm.nih.gov/31761656
Autor:
Umesh Hanumegowda, Sharon Zhang, Yan Chen, Zheng Liu, Ira B. Dicker, Zhufang Li, Sing-Yuen Sit, Ny Sin, Jacob Swidorski, Brian Terry, Himadri Samanta, Tricia Protack, Brian Lee Venables, Zeyu Lin, Yongnian Sun, Jie Chen, Beata Nowicka-Sans, Alicia Regueiro-Ren, Nicholas A. Meanwell, Matthew D. Healy, Mark Krystal, Mark I. Cockett
Publikováno v:
Antimicrobial Agents and Chemotherapy
BMS-955176 is a second-generation human immunodeficiency virus type 1 (HIV-1) maturation inhibitor (MI). A first-generation MI, bevirimat, showed clinical efficacy in early-phase studies, but ∼50% of subjects had viruses with reduced susceptibility
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::000fa48983f3b6ab685649499d7d0683
https://doi.org/10.1128/aac.02560-15
https://doi.org/10.1128/aac.02560-15
Autor:
Sing-Yuen Sit, Ny Sin, Umesh Hanumegowda, Dawn D. Parker, Zheng Liu, Alicia Regueiro-Ren, Xiaohua S. Huang, Brian Lee Venables, Brian Terry, Brett R. Beno, Sharon Zhang, Ira B. Dicker, Roy Haskell, Jacob Swidorski, Zhufang Li, Mark I. Cockett, Beata Nowicka-Sans, Zeyu Lin, Nicholas A. Meanwell, Tricia Protack, Sandhya Rahematpura, Juliang Zhu, Susan Jenkins, Himadri Samanta, Mark Krystal, Yan Chen, Kenneth S. Santone, Jie Chen
Publikováno v:
ACS Medicinal Chemistry Letters. 7:568-572
HIV-1 maturation inhibition (MI) has been clinically validated as an approach to the control of HIV-1 infection. However, identifying an MI with both broad polymorphic spectrum coverage and good oral exposure has been challenging. Herein, we describe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83c6472d1d93201556f25ce37013cceb
https://doi.org/10.1021/acsmedchemlett.6b00010
https://doi.org/10.1021/acsmedchemlett.6b00010
Autor:
Jacob Swidorski, Zeyu Lin, Brian Terry, Ira B. Dicker, Sandhya Rahematpura, Dawn D. Parker, Alicia Regueiro-Ren, Nicholas A. Meanwell, Himadri Samanta, Zheng Liu, Beata Nowicka-Sans, Brett R. Beno, Sharon Zhang, Zhufang Li, Mark Krystal, Susan Jenkins, Tricia Protack
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:1757-1770
A series of C-3 phenyl- and heterocycle-substituted derivatives of C-3 deoxybetulinic acid and C-3 deoxybetulin was designed and synthesized as HIV-1 maturation inhibitors (MIs) and evaluated for their antiviral activity and cytotoxicity in cell cult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::039baf6a00a721625ef5246bab7243cd
https://doi.org/10.1016/j.bmc.2016.03.001
https://doi.org/10.1016/j.bmc.2016.03.001
Autor:
Alicia, Regueiro-Ren, Jacob J, Swidorski, Zheng, Liu, Yan, Chen, Ny, Sin, Sing-Yuen, Sit, Jie, Chen, Brian L, Venables, Juliang, Zhu, Beata, Nowicka-Sans, Tricia, Protack, Zeyu, Lin, Brian, Terry, Himadri, Samanta, Sharon, Zhang, Zhufang, Li, John, Easter, Brett R, Beno, Vinod, Arora, Xiaohua S, Huang, Sandhya, Rahematpura, Dawn D, Parker, Roy, Haskell, Kenneth S, Santone, Mark I, Cockett, Mark, Krystal, Nicholas A, Meanwell, Susan, Jenkins, Umesh, Hanumegowda, Ira B, Dicker
Publikováno v:
Journal of medicinal chemistry. 61(16)
GSK3532795, formerly known as BMS-955176 (1), is a potent, orally active, second-generation HIV-1 maturation inhibitor (MI) that advanced through phase IIb clinical trials. The careful design, selection, and evaluation of substituents appended to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ec69348335bb02844efe70a17d779260
https://pubmed.ncbi.nlm.nih.gov/30067361
https://pubmed.ncbi.nlm.nih.gov/30067361
Autor:
Sagarika Bollini, Zeyu Lin, Brian Terry, Michael A. Walker, Himadri Samanta, Mark Krystal, Ira B. Dicker, Zhufang Li, Volodymyr Gali
Publikováno v:
Journal of Biological Chemistry. 283:23599-23609
In this study, eight different HIV-1 integrase proteins containing mutations observed in strand transfer inhibitor-resistant viruses were expressed, purified, and used for detailed enzymatic analyses. All the variants examined were impaired for stran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bae2419af13b51eda41d0d3e2a17222
https://doi.org/10.1074/jbc.m804213200
https://doi.org/10.1074/jbc.m804213200
Autor:
David R. Langley, Mark Krystal, Ira B. Dicker, Yang Hong, Yuan Tian, Himadri Samanta, Michael A. Walker, Roger Remillard, Zhufang Li, Jacques Banville
Publikováno v:
Journal of Biological Chemistry. 282:31186-31196
Human immunodeficiency virus (HIV) integrase enzyme is required for the integration of viral DNA into the host cell chromosome. Integrase complex assembly and subsequent strand transfer catalysis are mediated by specific interactions between integras
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbbc46c99870acdc6c1cc822b466ec87
https://doi.org/10.1074/jbc.m704935200
https://doi.org/10.1074/jbc.m704935200
Autor:
B. Narasimhulu Naidu, Ira B. Dicker, Roger Remillard, Michael A. Walker, Chen Li, Jacques Banville, Nicholas A. Meanwell, Albert Torri, Zeyu Lin, Mark Krystal, Timothy Norman Johnson, Serge Plamondon, Alain Martel, Himadri Samanta
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4886-4890
Integrase is one of three enzymes expressed by HIV and represents a validated target for therapy. Previous reports have demonstrated that the diketoacid-based chemotype is a useful starting point for the design of inhibitors of this enzyme. In this s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70352e8370c4913769887a2d5fd4015d
https://doi.org/10.1016/j.bmcl.2007.06.042
https://doi.org/10.1016/j.bmcl.2007.06.042