CNS Relapse in High-Grade B-cell Lymphoma with MYC and BCL2 Rearrangements and Dark-Zone Signature-Expressing DLBCL.

Autor: Alduaij W; University of British Columbia, Vancouver, British Columbia, Canada., Jiang A; BCCRC, Vancouver, Canada., Villa D; BC Cancer - Vancouver Cancer Centre, Vancouver, British Columbia, Canada., Collinge BJ; BC Cancer, Vancouver, British Columbia, Canada., Ben-Neriah S; BC Cancer Agency, Vancouver, BC, Canada., Boyle M; BC Cancer, Vancouver, British Columbia, Canada., Meissner B; BC Cancer Agency, Vancouver, Canada., Hilton LK; BC Cancer, Vancouver, British Columbia, Canada., Farinha P; British Columbia Cancer, Vancouver, Canada., Slack GW; British Columbia Cancer Agency, Vancouver, Canada., Craig JW; University of Virginia Health System, Charlottesville, Virginia, United States., Gerrie AS; University of British Columbia and BC Cancer, Vancouver, Canada., Freeman CL; H. Lee Moffitt Cancer Center, Tampa, Florida, United States., Mungall AJ; BC Cancer, Vancouver, British Columbia, Canada., Steidl C; BC Cancer, Vancouver, British Columbia, Canada., Sehn LH; BC Cancer, Vancouver, Canada., Scott DW; BC Cancer, Vancouver, British Columbia, Canada., Savage KJ; BC Cancer, Centre for Lymphoid Cancer, Vancouver, Canada.

Publikováno v: Blood [Blood] 2024 Oct 23. Date of Electronic Publication: 2024 Oct 23.

Integrated single cell analysis reveals co-evolution of malignant B cells and tumor micro-environment in transformed follicular lymphoma.

Autor: Sarkozy C, Wu S, Takata K, Aoki T, Neriah SB, Milne K, Goodyear T, Strong C, Rastogi T, Hilton LK, Lai D, Sehn LH, Farinha P, Nelson BH, Weng A, Marra M, Scott DW, Craig JW, Steidl C, Roth A

Publikováno v: Cancer cell [Cancer Cell] 2024 Sep 09; Vol. 42 (9), pp. 1630. Date of Electronic Publication: 2024 Aug 15.

Motive and opportunity: MYC rearrangements in high-grade B-cell lymphoma with MYC and BCL2 rearrangements (an LLMPP study).

Autor: Hilton LK; Centre for Lymphoid Cancer, BC Cancer, Vancouver, BC, Canada.; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada., Collinge B; Centre for Lymphoid Cancer, BC Cancer, Vancouver, BC, Canada.; Department of Pathology and Laboratory Medicine, The University of British Columbia, Vancouver, BC, Canada., Ben-Neriah S; Centre for Lymphoid Cancer, BC Cancer, Vancouver, BC, Canada., Alduaij W; Centre for Lymphoid Cancer, BC Cancer, Vancouver, BC, Canada., Shaalan H; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada., Weng AP; Terry Fox Laboratory, BC Cancer Research Institute, Vancouver, BC, Canada., Cruz M; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada., Slack GW; Centre for Lymphoid Cancer, BC Cancer, Vancouver, BC, Canada.; Department of Pathology and Laboratory Medicine, The University of British Columbia, Vancouver, BC, Canada., Farinha P; Centre for Lymphoid Cancer, BC Cancer, Vancouver, BC, Canada.; Department of Pathology and Laboratory Medicine, The University of British Columbia, Vancouver, BC, Canada., Miyata-Takata T; Centre for Lymphoid Cancer, BC Cancer, Vancouver, BC, Canada., Boyle M; Centre for Lymphoid Cancer, BC Cancer, Vancouver, BC, Canada., Meissner B; Centre for Lymphoid Cancer, BC Cancer, Vancouver, BC, Canada., Cook JR; Department of Clinical Pathology, Cleveland Clinic, Cleveland, OH., Ondrejka SL; Department of Clinical Pathology, Cleveland Clinic, Cleveland, OH., Ott G; Department of Clinical Pathology, Robert-Bosch-Krankenhaus and Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany., Rosenwald A; Institute of Pathology, University of Wurzburg, Wurzburg, Germany., Campo E; Hematopathology Section, Hospital Clinic of Barcelona, Institut d'Investigaciones Biomediques August Pi I Sunyer, University of Barcelona, Barcelona, Spain., Amador C; Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine, Miami, FL., Greiner TC; Department of Pathology, Microbiology and Immunology, University of Nebraska Medical Center, Omaha, NE., Raess PW; Department of Pathology and Laboratory Medicine, Oregon Health & Science University, Portland, OR., Song JY; Department of Pathology, City of Hope, Duarte, CA., Inghirami G; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY., Jaffe ES; Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD., Weisenburger DD; Department of Pathology, Microbiology and Immunology, University of Nebraska Medical Center, Omaha, NE., Chan WC; Department of Pathology, City of Hope, Duarte, CA., Beiske K; Department of Pathology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway., Fu K; Department of Pathology and Laboratory Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY., Delabie J; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Pittaluga S; Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD., Iqbal J; Department of Pathology, Microbiology and Immunology, University of Nebraska Medical Center, Omaha, NE., Wright G; Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD., Sehn LH; Centre for Lymphoid Cancer, BC Cancer, Vancouver, BC, Canada.; Division of Medical Oncology, Department of Medicine, The University of British Columbia, Vancouver, BC, Canada., Savage KJ; Centre for Lymphoid Cancer, BC Cancer, Vancouver, BC, Canada.; Division of Medical Oncology, Department of Medicine, The University of British Columbia, Vancouver, BC, Canada., Mungall AJ; Canada's Michael Smith Genome Sciences Centre, BC Cancer Research Institute, Vancouver, BC, Canada., Feldman AL; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN., Staudt LM; Lymphoid Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD., Steidl C; Centre for Lymphoid Cancer, BC Cancer, Vancouver, BC, Canada.; Department of Pathology and Laboratory Medicine, The University of British Columbia, Vancouver, BC, Canada., Rimsza LM; Department of Laboratory Medicine and Pathology, Mayo Clinic, Scottsdale, AZ., Morin RD; Centre for Lymphoid Cancer, BC Cancer, Vancouver, BC, Canada.; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada.; Canada's Michael Smith Genome Sciences Centre, BC Cancer Research Institute, Vancouver, BC, Canada., Scott DW; Centre for Lymphoid Cancer, BC Cancer, Vancouver, BC, Canada.; Division of Medical Oncology, Department of Medicine, The University of British Columbia, Vancouver, BC, Canada.

Publikováno v: Blood [Blood] 2024 Aug 01; Vol. 144 (5), pp. 525-540.

Biological heterogeneity in diffuse large B-cell lymphoma.

Autor: Hilton LK; BC Cancer Centre for Lymphoid Cancer, Vancouver, BC, Canada.; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada. Electronic address: lhilton@bccrc.ca., Scott DW; BC Cancer Centre for Lymphoid Cancer, Vancouver, BC, Canada.; Division of Medical Oncology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada., Morin RD; BC Cancer Centre for Lymphoid Cancer, Vancouver, BC, Canada.; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada; Canada's Michael Smith Genome Sciences Centre, BC Cancer Research Centre, Vancouver, BC, Canada.

Publikováno v: Seminars in hematology [Semin Hematol] 2023 Nov; Vol. 60 (5), pp. 267-276. Date of Electronic Publication: 2023 Dec 01.

Exploiting the fibroblast growth factor receptor-1 vulnerability to therapeutically restrict the MYC-EZH2-CDKN1C axis-driven proliferation in Mantle cell lymphoma.

Autor: Sircar A; Division of Hematology, College of Medicine, The Ohio State University, Columbus, OH, USA.; The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, USA., Singh S; Division of Hematology, College of Medicine, The Ohio State University, Columbus, OH, USA.; The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, USA., Xu-Monette ZY; Division of Hematopathology, Department of Pathology, Duke University Medical Center, Durham, NC, USA., Coyle KM; Department of Molecular Biology & Biochemistry, Simon Fraser University, Burnaby, BC, Canada., Hilton LK; Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada., Chavdoula E; The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, USA.; Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH, USA., Ranganathan P; Division of Hematology, College of Medicine, The Ohio State University, Columbus, OH, USA.; The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, USA., Jain N; Division of Cancer Biology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, 226031, India.; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh, 201002, India., Hanel W; Division of Hematology, College of Medicine, The Ohio State University, Columbus, OH, USA.; The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, USA., Tsichlis P; The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, USA.; Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH, USA., Alinari L; Division of Hematology, College of Medicine, The Ohio State University, Columbus, OH, USA.; The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, USA., Peterson BR; The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, USA.; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, USA., Tao J; Division of Pathology, University of Virginia, Charlottesville, VA, USA., Muthusamy N; Division of Hematology, College of Medicine, The Ohio State University, Columbus, OH, USA.; The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, USA., Baiocchi R; Division of Hematology, College of Medicine, The Ohio State University, Columbus, OH, USA.; The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, USA., Epperla N; Division of Hematology, College of Medicine, The Ohio State University, Columbus, OH, USA.; The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, USA., Young KH; Division of Hematopathology, Department of Pathology, Duke University Medical Center, Durham, NC, USA.; Duke Cancer Institute, Durham, NC, USA., Morin R; Department of Molecular Biology & Biochemistry, Simon Fraser University, Burnaby, BC, Canada.; Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer, Vancouver, BC, Canada., Sehgal L; Division of Hematology, College of Medicine, The Ohio State University, Columbus, OH, USA. Lalit.Sehgal@osumc.edu.; The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, USA. Lalit.Sehgal@osumc.edu.

Publikováno v: Leukemia [Leukemia] 2023 Oct; Vol. 37 (10), pp. 2094-2106. Date of Electronic Publication: 2023 Aug 19.