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Mutation at Positively Selected Positions in the Binding Site for HLA-C Shows That KIR2DL1 Is a More Refined but Less Adaptable NK Cell Receptor Than KIR2DL3

Autor: Peter Parham, Katharina Fleischhauer, Achim K. Moesta, Paul Norman, Luca Vago, Hugo G. Hilton, Laurent Abi-Rached, Anastazia M. Older Aguilar, Lisbeth A. Guethlein, Thorsten Graef

Through recognition of HLA class I, killer cell Ig-like receptors (KIR) modulate NK cell functions in human immunity and reproduction. Although a minority of HLA-A and -B allotypes are KIR ligands, HLA-C allotypes dominate this regulation, because th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5bb24b5e3186603ba6fd88fb5c8e68b

Genetic diversity affects the nanoscale membrane organization and signaling of natural killer cell receptors.

Autor: Kennedy PR; Manchester Collaborative Centre for Inflammation Research, University of Manchester, 46 Grafton Street, Manchester M13 9NT, UK., Barthen C; Manchester Collaborative Centre for Inflammation Research, University of Manchester, 46 Grafton Street, Manchester M13 9NT, UK., Williamson DJ; Manchester Collaborative Centre for Inflammation Research, University of Manchester, 46 Grafton Street, Manchester M13 9NT, UK., Pitkeathly WTE; Manchester Collaborative Centre for Inflammation Research, University of Manchester, 46 Grafton Street, Manchester M13 9NT, UK., Hazime KS; Manchester Collaborative Centre for Inflammation Research, University of Manchester, 46 Grafton Street, Manchester M13 9NT, UK., Cumming J; Manchester Collaborative Centre for Inflammation Research, University of Manchester, 46 Grafton Street, Manchester M13 9NT, UK., Stacey KB; Manchester Collaborative Centre for Inflammation Research, University of Manchester, 46 Grafton Street, Manchester M13 9NT, UK., Hilton HG; Department of Structural Biology, Stanford University School of Medicine, D159, Sherman Fairchild Science Building, 299 Campus Drive West, Stanford, CA 94305, USA., Carrington M; Basic Science Program, Frederick National Laboratory for Cancer Research, Building 560, Room 21-89, Frederick, MD 21702, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA., Parham P; Department of Structural Biology, Stanford University School of Medicine, D159, Sherman Fairchild Science Building, 299 Campus Drive West, Stanford, CA 94305, USA., Davis DM; Manchester Collaborative Centre for Inflammation Research, University of Manchester, 46 Grafton Street, Manchester M13 9NT, UK. daniel.davis@manchester.ac.uk.

Publikováno v: Science signaling [Sci Signal] 2019 Dec 17; Vol. 12 (612). Date of Electronic Publication: 2019 Dec 17.