Purinergic P2Y12 Receptor Activation in Eosinophils and the Schistosomal Host Response.

Autor: Valdirene S Muniz, Renata Baptista-Dos-Reis, Claudia F Benjamim, Hilton A Mata-Santos, Alexandre S Pyrrho, Marcelo A Strauch, Paulo A Melo, Amanda R R Vicentino, Juliana Silva-Paiva, Christianne Bandeira-Melo, Peter F Weller, Rodrigo T Figueiredo, Josiane S Neves

Publikováno v: PLoS ONE, Vol 10, Iss 10, p e0139805 (2015)

Identifying new target molecules through which eosinophils secrete their stored proteins may reveal new therapeutic approaches for the control of eosinophilic disorders such as host immune responses to parasites. We have recently reported the express

Externí odkaz: https://doaj.org/article/d8a82e81616a458aa59411fdc4e34a16

Intracerebral Injection of Heme Induces Lipid Peroxidation, Neuroinflammation, and Sensorimotor Deficits

Autor: Danillo Pereira Dantas, Luiz Ricardo Vasconcellos, Leonardo H. Travassos, Filipe Mota Fonseca, Rosalia Mendez-Otero, Letícia Martimiano, Hilton Antônio Mata-Santos, Marcelo T. Bozza, Pedro M. Pimentel-Coelho

Publikováno v: Stroke. 52(5)

Background and Purpose: Heme is a red blood cell component released in the brain parenchyma following intracerebral hemorrhage. However, the study of the pathophysiological mechanisms triggered by heme in the brain is hampered by the lack of well-est

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf1b902ae10990c152d14bcf5636ec36
https://pubmed.ncbi.nlm.nih.gov/33827248

Silymarin Reduces Profibrogenic Cytokines and Reverses Hepatic Fibrosis in Chronic Murine Schistosomiasis

Autor: Hilton Antônio Mata-Santos, Bryan Hudson Hossy, Leandro Andrade Chinalia, Alexandre dos Santos Pyrrho, Carolina Carneiro Rocha, Fabiana Gonçalves Lino, Claudia N. Paiva, Morgana T. Castelo-Branco, Anderson Junger Teodoro, Fabianno F. Dutra, Fabiola Ramos Xavier

Publikováno v: Antimicrobial Agents and Chemotherapy. 58:2076-2083

In chronic schistosomiasis, hepatic fibrosis is linked to the portal hypertension that causes morbidity in Schistosoma mansoni infection. Silymarin (SIL) is a hepatoprotective and antioxidant medicament largely prescribed against liver diseases that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b8a568ae66c43f238510199ba591a3d
https://doi.org/10.1128/aac.01936-13

Anthelmintic activity of lapachol, β-lapachone and its derivates againts Toxocara canis larvae

Autor: Paula F. Carneiro, Taís Mata-Santos, Maria do Carmo F. R. Pinto, Nitza Souto França Pinto, Carlos James Scaini, Karina Pena Del Rio, Lourdes Helena Rodrigues Martins, Hilton Antônio Mata-Santos, Kelly Gallan De Moura, Juliana Montelli Fenalti, Pedro Eduardo Almeida da Silva, Tatiane Dos Santos Carvalho

Publikováno v: Repositório Institucional da FURG (RI FURG)
Universidade Federal do Rio Grande (FURG)
instacron:FURG
Revista do Instituto de Medicina Tropical de São Paulo
Revista do Instituto de Medicina Tropical de São Paulo, Vol 57, Iss 3, Pp 197-204 (2015)

Anthelmintics used for intestinal helminthiasis treatment are generally effective; however, their effectiveness in tissue parasitosis (i.e. visceral toxocariasis) is moderate. The aim of this study was to evaluate the in vitro activity of lapachol, �

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47b37ab78d10d4c3c15b9171bc6927aa
http://repositorio.furg.br/handle/1/7181

Silymarin treatment reduces granuloma and hepatic fibrosis in experimental schistosomiasis

Autor: Carolina Carneiro Rocha, Claudia N. Paiva, Alexandre dos Santos Pyrrho, Morgana Teixeira Lima Castelo Branco, Hilton Antônio Mata-Santos, Fabiana Gonçalves Lino

Publikováno v: Parasitology research. 107(6)

The schistosomiasis is a parasitic infection with relevant social impact and an important health problem in many countries around world. The pathology of this infection is characterized by a granulomatous reaction around parasite eggs and by hepatic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd78b2c8f3fe65046c4543a1c76bb7d
https://pubmed.ncbi.nlm.nih.gov/20694562