Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Hilmi Orhan"'
Publikováno v:
Pharmaceutics, Vol 16, Iss 7, p 871 (2024)
The need to create safe materials for biomedical and pharmaceutical applications has become a significant driving force for the development of new systems. Therefore, a chitosan-coated copolymer of itaconic acid, acrylic acid, and N-vinyl caprolactam
Externí odkaz:
https://doaj.org/article/c50ff2b96afb4e8c86909d0372932c43
Publikováno v:
Toxicology Letters. 363:36-44
Mitochondria appeared to be a major target for paracetamol (PAR)-induced hepatotoxicity. Studies suggested that microsomal CYPs catalyse bioactivation of PAR to N-acetyl-p-benzoquinone imine (NAPQI), which alkylates mitochondrial proteins, and causes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a773015bbd6cb09994fa2920386d197
https://doi.org/10.1016/j.toxlet.2022.05.005
https://doi.org/10.1016/j.toxlet.2022.05.005
Publikováno v:
Endocrine, Metabolic & Immune Disorders - Drug Targets. 23
Aim: To provide in vitro data on toxicity mechanisms of clozapine, diclofenac and nifedipine. Background: CHO-K1 cells were used as in vitro model to explore mechanisms of cytotoxicity of the test drugs. Objective: Cytotoxic mechanisms of clozapine (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed0f8b2da53c93c0f2b0e8970b03cfa9
https://doi.org/10.2174/1871530323666230419084613
https://doi.org/10.2174/1871530323666230419084613
Autor:
Hilmi Orhan
Publikováno v:
Current Drug Metabolism. 22:657-669
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b2e7836e0f0d35982b37b2149ee5c0c
https://doi.org/10.2174/18755453mte2amzyw1
https://doi.org/10.2174/18755453mte2amzyw1
Autor:
Yvonne Will, Philip Hewitt, Hartmut Jaeschke, Hilmi Orhan, Mathieu Vinken, Kendall B. Wallace
Publikováno v:
Applied In Vitro Toxicology. 5:167-172
Mitochondria play critical roles in all cell types. They are involved in processes such as calcium storage and signaling, cell proliferation, apoptosis, steroid synthesis, immunity, energy balance, and heat production. Inherent to these vital functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d56f70206754245ddb12c0b59630062f
https://doi.org/10.1089/aivt.2019.29022.rtl
https://doi.org/10.1089/aivt.2019.29022.rtl
Autor:
Hilmi Orhan
Publikováno v:
Toxicology for the Health and Pharmaceutical Sciences ISBN: 9780203730584
Toxicology for the Health and Pharmaceutical Sciences
Toxicology for the Health and Pharmaceutical Sciences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b041aa32e28e8528d64b1815c25946b
https://doi.org/10.1201/9780203730584-3
https://doi.org/10.1201/9780203730584-3
Publikováno v:
Toxicology for the Health and Pharmaceutical Sciences ISBN: 9780203730584
Toxicology for the Health and Pharmaceutical Sciences
Toxicology for the Health and Pharmaceutical Sciences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bd4757a6ffeb2d334bae3eafa6f76b2
https://doi.org/10.1201/9780203730584-12
https://doi.org/10.1201/9780203730584-12
In vivo biotransformation of exposed chemicals is one of the major factors that determine the concentration and the duration of a substance at the systemic site of effect. Given that toxicity is expressed as a function of two factors, namely dose and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f00c91b274bbc9d410f972609ef63b25
https://avesis.yyu.edu.tr/publication/details/3358f945-21f9-447d-8188-b28660c7441b/oai
https://avesis.yyu.edu.tr/publication/details/3358f945-21f9-447d-8188-b28660c7441b/oai
Autor:
Hilmi Orhan
[No Abstract Available]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6a12767be782c3f64f6e040fc7c6e3a
https://hdl.handle.net/11454/79130
https://hdl.handle.net/11454/79130
Autor:
Yavuz Ergun, Serdar Durdagi, Zeki Topcu, Á. Kulmány, M. Zaka, Kader Sahin, István Zupkó, Sevil Zencir, M. Kuskucu, V. Akyildiz, Hilmi Orhan
The compounds reducing tumor cell viability and disrupting DNA topoisomerase reactions have been widely used in anticancer drug development. Ellipticine (5,11-dimethyl-6H-pyrido[4,3-b]carbazole) is a potent intercalating agent that interferes with nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b2de3987d1a58efe767ceaedadbde0b
https://avesis.deu.edu.tr/publication/details/9e8b704c-2c4e-4d59-922b-200d244321d7/oai
https://avesis.deu.edu.tr/publication/details/9e8b704c-2c4e-4d59-922b-200d244321d7/oai