Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Hilmar Bischoff"'
Autor:
Holger Paulsena, Siegfried Zaiss, Delf Schmidt, Hilmar Bischoff, Klaus-Dieter Bremm, Paul Naab, Michael Lögers, Stephan N. Wirtz, Jürgen Stoltefuss, Gunter Schmidt, Arndt Brandes, Carsten Schmeck, Stefan Antons
Publikováno v:
CHIMIA, Vol 58, Iss 3 (2004)
The inhibition of the cholesteryl ester transfer protein (CETP) provides a method for the elevation of the high density lipoprotein cholesterol (HDL-C) level, i.e. the 'good' cholesterol. The expected anti-atherogenic effect of this approach is inde
Externí odkaz:
https://doaj.org/article/ecc93d90677b4787979a5008cafe3ab9
Autor:
Frank-Thorsten Hafner, Carsten Schmeck, Roland Heinig, Alexandros Vakalopoulos, Hilmar Bischoff, Klemens Lustig, Klaus Buehner, Stefan Willmann, Volkhart Min-Jian Li, Olaf Weber
Publikováno v:
British Journal of Clinical Pharmacology. 73:219-231
The purpose of this work was to support the prediction of a potentially effective dose for the CETP-inhibitor, BAY 60-5521, in humans.A combination of allometric scaling of the pharmacokinetics of the CETP-inhibitor BAY 60-5521 with pharmacodynamic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0bef16ac0e693cddb037a092a49ba25
https://doi.org/10.1111/j.1365-2125.2011.04064.x
https://doi.org/10.1111/j.1365-2125.2011.04064.x
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:3648-3653
Novel squalene synthase inhibitors are disclosed. The design, synthesis, SAR and pharmacological profile of the compounds are discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::703c648ed73d2200aa116662bd6c634e
https://doi.org/10.1016/j.bmcl.2011.04.092
https://doi.org/10.1016/j.bmcl.2011.04.092
Autor:
Carsten Schmeck, Alexandros Vakalopoulos, Volkhart Min-Jian Li, Hilmar Bischoff, Olaf Weber, Michael Thutewohl, Harry Elias, Klemens Lustig, Holger Paulsen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:488-491
Based on our former development candidate BAY 38-1315, optimization efforts led to the discovery of a novel chemical class of orally active cholesteryl ester transfer protein (CETP) inhibitors. The chromanol derivative 19b is a highly potent CETP inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d152e8c259b73428bcce8bbb0975efd3
https://doi.org/10.1016/j.bmcl.2010.10.110
https://doi.org/10.1016/j.bmcl.2010.10.110
Autor:
Hilmar Bischoff, Klemens Lustig, Michael Woltering, Klaus Urbahns, Josef Pernerstorfer, Elke Dittrich-Wengenroth, Susanne Nikolic
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:3376-3379
The design, synthesis and pharmacological properties of a novel class of PPARα agonists is described. Compound 2 is a novel, potent and specific glycine amide with oral bioavailability in rodents. The compound is active in vivo and alters plasma lip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::991ee9af1809c9f3f4cbdd71e599d67d
https://doi.org/10.1016/j.bmcl.2010.04.019
https://doi.org/10.1016/j.bmcl.2010.04.019
Autor:
Carsten Schmeck, Helmut Haning, Axel Kretschmer, Verena Voehringer, Gunter Schmidt, Ulrich Dr Mueller, Hilmar Bischoff
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:3992-3996
Novel heterocyclic thyromimetics are presented carrying carboxy-substituted benzofurans or sulfur containing heterocycles, as replacements for the amino acid side chain of T3. Potent agonists were identified in both series. SAR trends are examined an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b21dd5624990b73886f28d293ec138
https://doi.org/10.1016/j.bmcl.2007.04.085
https://doi.org/10.1016/j.bmcl.2007.04.085
Autor:
Heike Heckroth, Stefan Weigand, Hilmar Bischoff, Andrea Vaupel, Michael Woltering, Elke Dittrich-Wengenroth, Dieter Lang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:4619-4623
We report the solid-phase synthesis and pharmacological evaluation of a new series of small-molecule agonists of the human peroxisome proliferator-activated receptor δ (PPARδ) based on a lead structure from our PPARα program. Compound 33 showed go
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d22f2cebeafd2d8079c34312bcc0a028
https://doi.org/10.1016/j.bmcl.2005.06.023
https://doi.org/10.1016/j.bmcl.2005.06.023
Autor:
Hilmar Bischoff, Laura Calvillo, Inka Elbing, Johann Bauersachs, Jochen Tillmanns, Charlotte Dienesch, Georg Ertl, Stefan Frantz
Publikováno v:
The FASEB Journal. 19:1-13
Protective effects of the alpha-glucosidase inhibitor acarbose have been reported for various diabetic complications. In the STOP-NIDDM study, even patients without overt diabetes, but with impaired glucose tolerance, had a reduction in cardiovascula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::678d5f4bea4d66ac4c25be42c6726011
https://doi.org/10.1096/fj.04-2459fje
https://doi.org/10.1096/fj.04-2459fje
Autor:
Johann Bauersachs, Georg Ertl, Julian D. Widder, Martin Eigenthaler, Hilmar Bischoff, Andreas Schäfer
Publikováno v:
Thrombosis and Haemostasis. 92:97-103
SummaryPatients with diabetes display increased platelet activation. Recent data show a markedly increased risk for cardiovascular events already in pre-diabetic individuals with impaired glucose tolerance (IGT). We investigated whether IGT is associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3203f81fa906914e612797e2e67c6d09
https://doi.org/10.1160/th04-02-0118
https://doi.org/10.1160/th04-02-0118
Publikováno v:
European Journal of Pharmacology. 445:141-148
Genetically (fa/fa) obese Zucker rats represent an established model of impaired glucose tolerance, with profound insulin resistance. Acarbose, an inhibitor of alpha-glucosidases, attenuates postprandial blood glucose peaks, and improves glucose tole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29672c52d9517c137ea3d20e3e2c22bd
https://doi.org/10.1016/s0014-2999(02)01714-4
https://doi.org/10.1016/s0014-2999(02)01714-4