Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Hillel Zukor"'
Publikováno v:
Glia. 63:1270-1284
Background Over-expression of the heme-degrading enzyme, heme oxygenase-1 (HO-1) promotes iron deposition, mitochondrial damage, and autophagy in astrocytes and enhances the vulnerability of nearby neuronal constituents to oxidative injury. These neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1a260c5eec487961502a2c6803f1bcb
https://doi.org/10.1002/glia.22823
https://doi.org/10.1002/glia.22823
Autor:
Carmela Galindez, Marisa Cressatti, Adrienne Liberman, Wei Song, Hillel Zukor, Hyman M. Schipper
Publikováno v:
Neurobiology of aging. 58
Epigenetic influences mediating brain iron deposition, oxidative mitochondrial injury, and macroautophagy in Parkinson disease and related conditions remain enigmatic. Here, we show that selective overexpression of the stress protein, heme oxygenase-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e6314ddc62efcf767719201b884c0dd
https://pubmed.ncbi.nlm.nih.gov/28746897
https://pubmed.ncbi.nlm.nih.gov/28746897
Autor:
Wei Song, Christina Holcroft, Hyman M. Schipper, David A. Bennett, Jacob Vaya, Jacob R. Hascalovici, Soliman Khatib, Hillel Zukor, Zoe Arvanitakis
Publikováno v:
Journal of Neurochemistry. 110:1241-1253
The objective of this study was to ascertain the impact of aging and Alzheimer’s disease (AD) on brain cholesterol (CH), CH precursors, and oxysterol homeostasis. Altered CH metabolism and up-regulation of heme oxygenase-1 (HO-1) are characteristic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e362204668aade5211b8c4a43638810b
https://doi.org/10.1111/j.1471-4159.2009.06213.x
https://doi.org/10.1111/j.1471-4159.2009.06213.x
Autor:
Shih-Hsiung, Lin, Wei, Song, Marisa, Cressatti, Hillel, Zukor, Eugenia, Wang, Hyman M, Schipper
Publikováno v:
Glia. 63(7)
Over-expression of the heme-degrading enzyme, heme oxygenase-1 (HO-1) promotes iron deposition, mitochondrial damage, and autophagy in astrocytes and enhances the vulnerability of nearby neuronal constituents to oxidative injury. These neuropathologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::574045f15c2432b393157f9529276356
https://pubmed.ncbi.nlm.nih.gov/25820186
https://pubmed.ncbi.nlm.nih.gov/25820186
Autor:
Zoe Arvanitakis, Hillel Zukor, Wei Song, Adrienne Liberman, Sagi Kaduri, Hyman M. Schipper, David A. Bennett
Publikováno v:
Experimental neurology. 254
Corpora amylacea (CA) are glycoproteinaceous (predominantly glial and extracellular) inclusions that accumulate in normal aging brain and, to a greater extent, in Alzheimer disease (AD). Previous pharmacological evidence suggested that up-regulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7729f6626edf6031f972425dd940eda0
https://pubmed.ncbi.nlm.nih.gov/24440642
https://pubmed.ncbi.nlm.nih.gov/24440642
Autor:
Lalit K. Srivastava, Edith Hamel, Hyman M. Schipper, Wei Song, Adrienne Liberman, Xin Kang Tong, Sanjeev K. Bhardwaj, Jeannie Mui, Shih Hsiung Lin, Hojatollah Vali, Ayda Tavitian, Jacob R. Hascalovici, Hillel Zukor
Delineation of key molecules that act epigenetically to transduce diverse stressors into established patterns of disease would facilitate the advent of preventive and disease-modifying therapeutics for a host of neurological disorders. Herein, we dem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4985c5cdd4483eba4b4b0cf128665304
https://europepmc.org/articles/PMC6621004/
https://europepmc.org/articles/PMC6621004/
Autor:
Wei Song, Jeannie Mui, Hyman M. Schipper, Adrienne Liberman, Ayda Tavitian, Hillel Zukor, Shih-Hsiung Lin, Jean-Luc Guerquin-Kern, Ting-Di Wu, Kostas Pantopoulos, Hojatollah Vali, Carine Fillebeen
Publikováno v:
Journal of neurochemistry. 123(2)
The mechanisms responsible for pathological iron deposition in the aging and degenerating mammalian CNS remain poorly understood. The stress protein, HO-1 mediates the degradation of cellular heme to biliverdin/bilirubin, free iron, and CO and is up-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f7405526ae1a2a4f2c9ccaca928d36
https://pubmed.ncbi.nlm.nih.gov/22881289
https://pubmed.ncbi.nlm.nih.gov/22881289
Publikováno v:
Journal of neurochemistry. 110(2)
The heme oxygenases (HOs), responsible for the degradation of heme to biliverdin/bilirubin, free iron and CO, have been heavily implicated in mammalian CNS aging and disease. In normal brain, the expression of HO-2 is constitutive, abundant and fairl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3a0e02d3bb639380f23d2d09fc37032
https://pubmed.ncbi.nlm.nih.gov/19457088
https://pubmed.ncbi.nlm.nih.gov/19457088
Cystatin B deficiency sensitizes neurons to oxidative stress in progressive myoclonus epilepsy, EPM1
Autor:
Azad Bonni, Haixiang Su, Outi Kopra, Anna-Elina Lehesjoki, Hillel Zukor, Saara Tegelberg, Paula Hakala, Maria K. Lehtinen, Otto Manninen, Hyman M. Schipper, Tarja Joensuu
The progressive myoclonus epilepsies, featuring the triad of myoclonus, seizures, and ataxia, comprise a large group of inherited neurodegenerative diseases that remain poorly understood and refractory to treatment. TheCystatin Bgene is mutated in on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1be76c167ff6c5d014acd51fab540e9
https://europepmc.org/articles/PMC2694495/
https://europepmc.org/articles/PMC2694495/
Autor:
Adrienne Liberman, Carine Fillebeen, Wei Song, Hillel Zukor, Jean-Luc Guerquin-Kern, Ting-Di Wu, Hyman M. Schipper, Jeannie Mui, Hojatollah Vali, Kostas Pantopoulos
Publikováno v:
Journal of neurochemistry. 109(3)
Oxidative stress, deposition of non-transferrin iron, and mitochondrial insufficiency occur in the brains of patients with Alzheimer disease (AD) and Parkinson disease (PD). We previously demonstrated that heme oxygenase-1 (HO-1) is up-regulated in A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ea081e3249f4923f9ba151a4f440eb
https://pubmed.ncbi.nlm.nih.gov/19250338
https://pubmed.ncbi.nlm.nih.gov/19250338