Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Hillary F. Green"'
Autor:
Albert C. Pan, Celine Valant, Arthur Christopoulos, James R. Valcourt, Hillary F. Green, Raphaël Rahmani, Patrick M. Sexton, David E. Shaw, Jonathan B. Baell, Daniel H. Arlow, Meritxell Canals, Ron O. Dror, David W. Borhani, J. Robert Lane
Publikováno v:
Nature. 503:295-299
Binding modes and molecular mechanisms of several allosteric modulators of a prototypical G-protein-coupled receptor are revealed using atomic-level simulations and validated by the rational design of a modulator with substantially altered effects. A
Autor:
Daniel Palmer, Cheng Zhang, Shaun R. Coughlin, Yoga Srinivasan, Anjali Pandey, Daniel H. Arlow, Ron O. Dror, Yaowu Zheng, David E. Shaw, Brian K. Kobilka, William I. Weis, Hillary F. Green, Juan Jose Fung
Publikováno v:
Nature. 492:387-392
Protease-activated receptor 1 (PAR1) is the prototypical member of a family of G-protein-coupled receptors that mediate cellular responses to thrombin and related proteases. Thrombin irreversibly activates PAR1 by cleaving the amino-terminal exodomai
Autor:
Erica Rosemond, Pil Seok Chae, Hillary F. Green, William I. Weis, Jürgen Wess, Andrew C. Kruse, David E. Shaw, Daniel M. Rosenbaum, Ron O. Dror, Tong Liu, Daniel H. Arlow, Jianxin Hu, Brian K. Kobilka, Albert C. Pan
Publikováno v:
Nature
Acetylcholine, the first neurotransmitter to be identified, exerts many of its physiological actions via activation of a family of G-protein-coupled receptors (GPCRs) known as muscarinic acetylcholine receptors (mAChRs). Although the five mAChR subty
Autor:
Patrick M. Sexton, Albert C. Pan, Hillary F. Green, J. Robert Lane, Daniel H. Arlow, David E. Shaw, David W. Borhani, Celine Valant, Meritxell Canals, Raphaël Rahmani, Arthur Christopoulos, James R. Valcourt, Jonathan B. Baell, Ron O. Dror
Publikováno v:
Biophysical Journal. 106:100a
The design of G protein-coupled receptor (GPCR) allosteric modulators, an active area of modern pharmaceutical research, has proven challenging because neither the binding modes nor the molecular mechanisms of such drugs are known. Here we determined