Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Hillary C. St. John"'
Publikováno v:
Journal of Cellular Biochemistry. 118:1050-1064
Epidemiological and clinical data suggest adverse cardiovascular outcomes with respect to vitamin D deficiency. Here, we explored the effects of vitamin D in atherosclerotic plaque calcification in vivo by utilizing vitamin D receptor (Vdr)-deficient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3a971786b3d2e344d80e05fb70c2013
https://doi.org/10.1002/jcb.25679
https://doi.org/10.1002/jcb.25679
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 164:277-280
Transcribed from the SOST gene, sclerostin is an osteocyte-derived negative regulator of bone formation that inhibits osteoblastogenesis via antagonism of the Wnt pathway. Sclerostin is a promising therapeutic target for low bone mass diseases and ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec03ccd2bf6f18fdf213ed87307e7db0
https://doi.org/10.1016/j.jsbmb.2015.09.005
https://doi.org/10.1016/j.jsbmb.2015.09.005
Publikováno v:
Journal of Bone and Mineral Research. 31:416-429
Receptor activator of nuclear factor-κB ligand (RANKL) is a tumor necrosis factor (TNF)-like cytokine that is necessary for osteoclast formation and survival. Elevated RANKL synthesis is associated with both increased osteoclast number and bone reso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53bb96f935357cf2aa8885e3e88c2765
https://doi.org/10.1002/jbmr.2698
https://doi.org/10.1002/jbmr.2698
Autor:
J. Wesley Pike, Mark B. Meyer, Alex H. Carlson, Hillary C. St. John, Mathew Prideaux, Lynda F. Bonewald, Nancy A. Benkusky
Publikováno v:
Bone. 72:81-91
Although localized to the mineralized matrix of bone, osteocytes are able to respond to systemic factors such as the calciotropic hormones 1,25(OH)2D3 and PTH. In the present studies, we examined the transcriptomic response to PTH in an osteocyte cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b1e8a7cf835364370716a8788e479a
https://doi.org/10.1016/j.bone.2014.11.010
https://doi.org/10.1016/j.bone.2014.11.010
Autor:
Ning Leng, Christina Kendziorski, Lynda F. Bonewald, J. Wesley Pike, Mark B. Meyer, Kathleen A. Bishop, Nancy A. Benkusky, Hillary C. St. John
Publikováno v:
Molecular Endocrinology. 28:1150-1165
Osteocytes are derived from osteoblast lineage cells that become progressively embedded in mineralized bone. Development of the osteocytogenic cell line IDG-SW3 has enabled a temporal and mechanistic investigation of this process. Through RNA-sequenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd2d3a8878d2c95b022d5fdbddea2f3
https://doi.org/10.1210/me.2014-1091
https://doi.org/10.1210/me.2014-1091
Publikováno v:
Journal of cellular biochemistry. 118(5)
Epidemiological and clinical data suggest adverse cardiovascular outcomes with respect to vitamin D deficiency. Here, we explored the effects of vitamin D in atherosclerotic plaque calcification in vivo by utilizing vitamin D receptor (Vdr)-deficient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::13399345ef507691380c71241092acad
https://pubmed.ncbi.nlm.nih.gov/27567005
https://pubmed.ncbi.nlm.nih.gov/27567005
Autor:
Hillary C. St. John, Seong Min Lee, J. Wesley Pike, Mark B. Meyer, Alex H. Carlson, Melda Onal, Nancy A. Benkusky, Sohel Shamsuzzaman
Insight into mechanisms that link the actions of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) to the regulation of gene expression has evolved extensively since the initial discovery of a nuclear protein known as the vitamin D receptor (VDR). Perhaps most
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4961d760316fb25f8e77144dfb3f0f6e
https://europepmc.org/articles/PMC5113140/
https://europepmc.org/articles/PMC5113140/
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 164
Transcribed from the SOST gene, sclerostin is an osteocyte-derived negative regulator of bone formation that inhibits osteoblastogenesis via antagonism of the Wnt pathway. Sclerostin is a promising therapeutic target for low bone mass diseases and ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e5456d3a29f8a5ac6821978f4572ab18
https://pubmed.ncbi.nlm.nih.gov/26361013
https://pubmed.ncbi.nlm.nih.gov/26361013
Genomic annotation of unique and combinatorial epigenetic modifications along with transcription factor occupancy is having a profound impact on our understanding of the genome. These studies have led to a better appreciation of the dynamic nature of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::068079b1361f81c600e04b0fe5882795
https://europepmc.org/articles/PMC4584159/
https://europepmc.org/articles/PMC4584159/
Autor:
Melda Onal, Marilina Piemontese, Jinhu Xiong, Kathleen A. Bishop, Erin M. Riley, J. Wesley Pike, Hillary C. St. John, Joseph J. Goellner, Allison L Danielson, Charles A. O'Brien
Publikováno v:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 30(5)
Receptor activator of NF-κB ligand (RANKL) is a TNFα-like cytokine that is produced by a diverse set of lineage-specific cells and is involved in a wide variety of physiological processes that include skeletal remodeling, lymph node organogenesis,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e515b0eb9cdbff26e916f33831868ee
https://pubmed.ncbi.nlm.nih.gov/25431114
https://pubmed.ncbi.nlm.nih.gov/25431114