Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Hill Malcolm Leithhead"'
Autor:
John H. A. Amery, Stefan Andreas Lange, Hill Malcolm Leithhead, Robert Simler, Leigh Dixon, Frank Gielen, Cinzia Gazziola, Doug P. Nesta, Jale Muslehiddinoglu, Kirsten Storch, Claudia Mueller, Jeremy D. Prail, Anna L. Watson
Publikováno v:
Nucleic Acid Therapeutics
The most common approach for the manufacture of oligonucleotides includes isolation of the active pharmaceutical ingredient (API) via lyophilization to provide a solid product, which is then dissolved to provide an aqueous formulation. It is well kno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0aaafb3daa2f2511a77619b48c69f0a
https://doi.org/10.1089/nat.2020.0846
https://doi.org/10.1089/nat.2020.0846
Autor:
Anna Tivesten, Nadim Akhtar, Thomas Eichinger, Achim Geiser, Jessica A. Stolee, Tobias Metzenthin, Rachel Orr, Hill Malcolm Leithhead, Yannick Fillon, Tom Huybrechts, Leo Van den Bergh, John H. A. Amery, Andrea Brecht, Paul McCormac, Jale Muslehiddinoglu
Publikováno v:
Therapeutic Innovation & Regulatory Science. 52:687-688
A consortium of seven pharma companies has been formed with the aim of sharing knowledge on and harmonizing approaches to oligonucleotide development. This letter aims to raise awareness of this new group and to set expectations for future publicatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6830ffcd2324f141bc8df223db98c16
https://doi.org/10.1177/2168479018793626
https://doi.org/10.1177/2168479018793626
Publikováno v:
ChemInform. 37
A practical enantioselective synthesis of lamivudine 1 is described. A highly effective dynamic kinetic resolution of the 5-hydroxyoxathiolane, followed by chlorination and introduction of cytosine provides an efficient synthesis of lamivudine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c71a8d1036852d8835edadba1d048a03
https://doi.org/10.1002/chin.200612225
https://doi.org/10.1002/chin.200612225