Development and Initial Characterization of Pigs with DNAI1 Mutations and Primary Ciliary Dyskinesia.

Autor: Abou Alaiwa MA; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Department of Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa 52242., Hilkin BM; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Price MP; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Gansemer ND; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Rector MR; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Stroik MR; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Powers LS; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Whitworth KM; Division of Animal Sciences, University of Missouri, Columbia, Missouri 65211., Samuel MS; Division of Animal Sciences, University of Missouri, Columbia, Missouri 65211., Jain A; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Ostedgaard LS; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Ernst SE; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Philibert W; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa 52242., Boyken LD; Department of Pathology, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Moninger TO; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Karp PH; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Hornick DB; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Sinn PL; Department of Pediatrics, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Department of Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Fischer AJ; Department of Pediatrics, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Department of Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Pezzulo AA; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Department of Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., McCray PB Jr; Department of Pediatrics, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Department of Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Meyerholz DK; Department of Pathology, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Zabner J; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Department of Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Prather RS; Division of Animal Sciences, University of Missouri, Columbia, Missouri 65211., Welsh MJ; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Department of Molecular Physiology and Biophysics, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Department of Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Howard Hughes Medical Institute, University of Iowa, Iowa City, Iowa 52242., Stoltz DA; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Department of Molecular Physiology and Biophysics, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Department of Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa 52242.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Aug 21. Date of Electronic Publication: 2024 Aug 21.

Arteriovenous metabolomics in pigs reveals CFTR regulation of metabolism in multiple organs.

Autor: Bae H; Department of Biological Chemistry, University of California - Irvine, Irvine, California, USA., Kim BR; Department of Internal Medicine, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.; Howard Hughes Medical Institute, University of Iowa, Iowa City, Iowa, USA., Jung S; Department of Biological Chemistry, University of California - Irvine, Irvine, California, USA., Le J; Department of Biological Chemistry, University of California - Irvine, Irvine, California, USA., van der Heide D; Department of Surgery and., Yu W; Department of Internal Medicine, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.; Howard Hughes Medical Institute, University of Iowa, Iowa City, Iowa, USA., Park SH; Department of Biological Chemistry, University of California - Irvine, Irvine, California, USA., Hilkin BM; Department of Internal Medicine, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA., Gansemer ND; Department of Internal Medicine, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA., Powers LS; Department of Internal Medicine, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA., Kang T; Department of Biological Chemistry, University of California - Irvine, Irvine, California, USA., Meyerholz DK; Department of Pathology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA., Schuster VL; Department of Internal Medicine, Albert Einstein College of Medicine, Bronx, New York, New York, USA., Jang C; Department of Biological Chemistry, University of California - Irvine, Irvine, California, USA.; Center for Complex Biological Systems and.; Center for Epigenetics and Metabolism, University of California - Irvine, Irvine, California, USA., Welsh MJ; Department of Internal Medicine, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.; Howard Hughes Medical Institute, University of Iowa, Iowa City, Iowa, USA.; Department of Molecular Physiology and Biophysics, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2024 May 14; Vol. 134 (13). Date of Electronic Publication: 2024 May 14.

Elastic mucus strands impair mucociliary clearance in cystic fibrosis pigs.

Autor: Pino-Argumedo MI; Department of Internal Medicine, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242., Fischer AJ; Department of Pediatrics, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242., Hilkin BM; Department of Internal Medicine, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242., Gansemer ND; Department of Internal Medicine, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242., Allen PD; Department of Pediatrics, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242., Hoffman EA; Department of Radiology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242.; Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242., Stoltz DA; Department of Internal Medicine, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242.; Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242.; Department of Molecular Physiology and Biophysics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242., Welsh MJ; Department of Internal Medicine, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242.; Department of Molecular Physiology and Biophysics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242.; HHMI, University of Iowa, Iowa City, IA 52242., Abou Alaiwa MH; Department of Internal Medicine, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242.; Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Mar 29; Vol. 119 (13), pp. e2121731119. Date of Electronic Publication: 2022 Mar 24.

Mucus strands from submucosal glands initiate mucociliary transport of large particles.

Autor: Fischer AJ; Department of Pediatrics., Pino-Argumedo MI; Department of Internal Medicine and Pappajohn Biomedical Institute., Hilkin BM; Department of Internal Medicine and Pappajohn Biomedical Institute., Shanrock CR; Department of Pediatrics., Gansemer ND; Department of Internal Medicine and Pappajohn Biomedical Institute., Chaly AL; Department of Pediatrics., Zarei K; Department of Internal Medicine and Pappajohn Biomedical Institute.; Department of Biomedical Engineering., Allen PD; Department of Pediatrics., Ostedgaard LS; Department of Internal Medicine and Pappajohn Biomedical Institute., Hoffman EA; Department of Biomedical Engineering.; Department of Radiology, and., Stoltz DA; Department of Internal Medicine and Pappajohn Biomedical Institute.; Department of Biomedical Engineering.; Department of Molecular Physiology and Biophysics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA., Welsh MJ; Department of Internal Medicine and Pappajohn Biomedical Institute.; Department of Molecular Physiology and Biophysics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.; Howard Hughes Medical Institute, University of Iowa, Iowa City, Iowa USA., Alaiwa MHA; Department of Internal Medicine and Pappajohn Biomedical Institute.; Department of Biomedical Engineering.

Publikováno v: JCI insight [JCI Insight] 2019 Jan 10; Vol. 4 (1). Date of Electronic Publication: 2019 Jan 10.

Neutrophil azurophilic granule exocytosis is primed by TNF-α and partially regulated by NADPH oxidase.

Autor: Potera RM; 1 Department of Pediatrics, University of Texas Southwestern Medical Center, USA., Jensen MJ; 2 Department of Pediatrics, The University of Iowa, USA.; 3 The Inflammation Program, The University of Iowa and Veterans Affairs Medical Center, USA., Hilkin BM; 2 Department of Pediatrics, The University of Iowa, USA.; 3 The Inflammation Program, The University of Iowa and Veterans Affairs Medical Center, USA., South GK; 2 Department of Pediatrics, The University of Iowa, USA., Hook JS; 1 Department of Pediatrics, University of Texas Southwestern Medical Center, USA.; 4 Department of Microbiology, University of Texas Southwestern Medical Center, USA., Gross EA; 2 Department of Pediatrics, The University of Iowa, USA.; 3 The Inflammation Program, The University of Iowa and Veterans Affairs Medical Center, USA., Moreland JG; 1 Department of Pediatrics, University of Texas Southwestern Medical Center, USA.; 4 Department of Microbiology, University of Texas Southwestern Medical Center, USA.

Publikováno v: Innate immunity [Innate Immun] 2016 Nov; Vol. 22 (8), pp. 635-646. Date of Electronic Publication: 2016 Sep 23.