Výsledky vyhledávání

Single-transcript multiplex in situ hybridisation reveals unique patterns of dystrophin isoform expression in the developing mammalian embryo

Autor: Hildyard, J C W, Crawford, A H, Rawson, F, Riddell, D O, Harron, R C M, Piercy, R J

Background: The dystrophin gene has multiple isoforms: full-length dystrophin (dp427) is principally known for its expression in skeletal and cardiac muscle, but is also expressed in the brain, and several internal promoters give rise to shorter, N-t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::3c4216936e432e6aaf6d713e85a76f95

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Identification of qPCR reference genes suitable for normalizing gene expression in the mdx mouse model of Duchenne muscular dystrophy

Autor: Hildyard, J C W, Finch, A M, Wells, D J

Publikováno v: PLoS One

The mdx mouse is the most widely-used animal model of the human disease Duchenne muscular dystrophy, and quantitative PCR analysis of gene expression in the muscles of this animal plays a key role in the study of pathogenesis and disease progression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::94897ea7e9b77a77de9d47feaa223c58
https://researchonline.rvc.ac.uk/id/eprint/11913/1/11913.pdf

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Akademický článek

Transgenic Rescue of the LARGEmyd Mouse: A LARGE Therapeutic Window?

Autor: Hildyard, J. C. W.¹, Lacey, E.¹, Booler, H.¹, Hopkinson, M.¹, Wells, D. J.¹, Brown, S. C.¹ scbrown@rvc.ac.uk

Publikováno v: PLoS ONE. 7/28/2016, Vol. 11 Issue 7, p1-20. 20p.

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Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy

Autor: Amoasii, L, Hildyard, J C W, Li, H, Sanchez-Ortiz, E, Mireault, A, Caballero, D, Harron, R, Stathopoulou, T-R, Massey, C A, Shelton, J M, Bassel-Duby, R, Piercy, R J, Olson, E N

Publikováno v: SCIENCE

Mutations in the gene encoding dystrophin, a protein that maintains muscle integrity and function, cause Duchenne muscular dystrophy (DMD). The deltaE50-MD dog model of DMD harbors a mutation corresponding to a mutational “hotspot” in the human D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::f88f6b2d59111b0f2edc2b71741bff17
https://researchonline.rvc.ac.uk/id/eprint/11792/1/11792.pdf

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Focus on the Role of D-serine and D-amino Acid Oxidase in Amyotrophic Lateral Sclerosis/Motor Neuron Disease (ALS)

Autor: Kondori, N R, Paul, P, Robbins, J P, Liu, K, Hildyard, J C W, Wells, D J, De Belleroche, J S

Publikováno v: Frontiers in Molecular Biosciences

Highly pathogenic avian influenza (HPAI) H5N1 virus has been circulating in Vietnam since 2003, while outbreaks of HPAI H5N6 virus are more recent, having only been reported since 2014. Although the spatial distribution of H5N1 outbreaks and risk fac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::a2bca82700b2e93081cabf508a4d0ad6
https://researchonline.rvc.ac.uk/id/eprint/11227/1/11227.pdf

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