Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Hildur R. Helgadottir"'
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Mutations in homology-directed repair genes likeBRCA2are linked to breast cancer susceptibility. Here the authors generate mice with an inducible DNA break-reporter system and see high levels of homology-directed repair in proliferative mammary tissu
Externí odkaz:
https://doaj.org/article/05628ecc62f8432486b6a2626164ba2c
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
The mammary gland undergoes significant proliferative stages after birth, but little is known about how the developmental changes impact DNA double-strand break (DSB) repair. Mutations in multiple genes involved in homology-directed repair (HDR), con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b06b3eeeee1cdca0d8481f67bf08bbbc
http://europepmc.org/articles/PMC5093336
http://europepmc.org/articles/PMC5093336
Autor:
Maria Jasin, Hildur R. Helgadottir, Pernilla Roswall, Sanna-Maria Hede, Nanna Lindberg, Monica Nistér, Daniel Bråsäter, Lene Uhrbom, Ulrica K. Westermark, Anders Zetterberg
Publikováno v:
Neuro-oncology. 13(12)
Faithful replication and DNA repair are vital for maintenance of genome integrity. RAD51 is a central protein in homologous recombination repair and during replication, when it protects and restarts stalled replication forks. Aberrant RAD51 expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89a365ecc0bf298f2d01267f6f121bea
https://pubmed.ncbi.nlm.nih.gov/21926087
https://pubmed.ncbi.nlm.nih.gov/21926087
Publikováno v:
Methods in enzymology. 409
DNA damage repair is essential for the maintenance of genetic integrity in all organisms. Unrepaired or imprecisely repaired DNA can lead to mutagenesis, cell death, or malignant transformation. DNA damage in the form of double-strand breaks (DSBs) c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bd75810a84e219916e8274438371e47
https://pubmed.ncbi.nlm.nih.gov/16793422
https://pubmed.ncbi.nlm.nih.gov/16793422
Publikováno v:
Cancer Research. 72:PD09-10
Numerous factors are linked to breast cancer risk including reproductive history, early exposure to radiation, age and genetic background. Events that occur during specific stages of mammary development are believed to alter the lifetime risk of brea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bb26421d7ce4dd9a0312e318b48595e
https://doi.org/10.1158/0008-5472.sabcs12-pd09-10
https://doi.org/10.1158/0008-5472.sabcs12-pd09-10