Screening for Rare Coding Variants That Associate With the QTc Interval in Iceland

Autor: Gardar Sveinbjornsson, Bara D. Benediktsdottir, Gunnlaugur Sigfusson, Kristjan Norland, Olafur B. Davidsson, Rosa B. Thorolfsdottir, Vinicius Tragante, Gudny A. Arnadottir, Brynjar O. Jensson, Hildigunnur Katrinardottir, Run Fridriksdottir, Hallbera Gudmundsdottir, Hildur M. Aegisdottir, Brynjar Fridriksson, Gudmundur Thorgeirsson, Vidar Magnusson, Asmundur Oddsson, Patrick Sulem, Daniel F. Gudbjartsson, Hilma Holm, David O. Arnar, Kari Stefansson

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 14 (2023)

Background Long‐QT syndrome (LQTS) is a cardiac repolarization abnormality that can lead to sudden cardiac death. The most common causes are rare coding variants in the genes KCNQ1, KCNH2, and SCN5A. The data on LQTS epidemiology are limited, and i

Externí odkaz: https://doaj.org/article/17d57c9b972842698d6d13a40b67bbcb

Genetic insight into sick sinus syndrome

Autor: Jon K. Sigurdsson, Gudmundur Thorgeirsson, Ingileif Jonsdottir, Søren Brunak, Mette Nyegaard, Bjarni Torfason, Henrik Ullum, Hildur M Aegisdottir, Gudmundur L. Norddahl, Stefan Jonsson, Hilma Holm, Lilja Stefansdottir, Christian Torp-Pedersen, Ben Michael Brumpton, Asmundur Oddsson, Daniel F. Gudbjartsson, Vinicius Tragante, Kristoffer Sølvsten Burgdorf, Kari Stefansson, Erna V. Ivarsdottir, Stefania Benonisdottir, Kristjan E. Hjorleifsson, Cristen J. Willer, Kristian Hveem, David O. Arnar, Gardar Sveinbjornsson, Sridharan Rajamani, Rosa B. Thorolfsdottir, Karina Banasik, Ole Birger Pedersen, Solveig Gretarsdottir, Atli S Valgardsson, David Westergaard, Erik Sørensen, Gudmar Thorleifsson, Peter Weeke, Unnur Thorsteinsdottir, Olafur B. Davidsson, Gisli H. Halldorsson, Michael L. Frigge, Anna Helgadottir, Wei Zhou, Patrick Sulem, Henning Bundgaard, Kaspar René Nielsen

Publikováno v: Thorsteinsdottir, U, Gudbjartsson, D F, Holm, H, Stefansson, K & DBDS Genomic Consortium 2021, ' Genetic insight into sick sinus syndrome ', European Heart Journal, vol. 42, no. 20, pp. 1959-1971 . https://doi.org/10.1093/eurheartj/ehaa1108
Thorolfsdottir, R B, Sveinbjornsson, G, Aegisdottir, H M, Benonisdottir, S, Stefansdottir, L, Ivarsdottir, E V, Halldorsson, G H, Sigurdsson, J K, Torp-Pedersen, C, Weeke, P E, Brunak, S, Westergaard, D, Pedersen, O B, Sorensen, E, Nielsen, K R, Burgdorf, K S, Banasik, K, DBDS Genomic Consortium, Brumpton, B, Zhou, W, Oddsson, A, Tragante, V, Hjorleifsson, K E, Davidsson, O B, Rajamani, S, Jonsson, S, Torfason, B, Valgardsson, A S, Thorgeirsson, G, Frigge, M L, Thorleifsson, G, Norddahl, G L, Helgadottir, A, Gretarsdottir, S, Sulem, P, Jonsdottir, I, Willer, C J, Hveem, K, Bundgaard, H, Ullum, H, Arnar, D O, Thorsteinsdottir, U, Gudbjartsson, D F, Holm, H, Stefansson, K & Nyegaard, M 2021, ' Genetic insight into sick sinus syndrome ', European Heart Journal, vol. 42, no. 20, pp. 1959-1971 . https://doi.org/10.1093/eurheartj/ehaa1108
European Heart Journal
Thorolfsdottir, R B, Sveinbjornsson, G, Aegisdottir, H M, Benonisdottir, S, Stefansdottir, L, Ivarsdottir, E V, Halldorsson, G H, Sigurdsson, J K, Torp-Pedersen, C, Weeke, P E, Brunak, S, Westergaard, D, Pedersen, O B, Sorensen, E, Nielsen, K R, Burgdorf, K S, Banasik, K, Brumpton, B, Zhou, W, Oddsson, A, Tragante, V, Hjorleifsson, K E, Davidsson, O B, Rajamani, S, Jonsson, S, Torfason, B, Valgardsson, A S, Thorgeirsson, G, Frigge, M L, Thorleifsson, G, Norddahl, G L, Helgadottir, A, Gretarsdottir, S, Sulem, P, Jonsdottir, I, Willer, C J, Hveem, K, Bundgaard, H, Ullum, H, Arnar, D O, Thorsteinsdottir, U, Gudbjartsson, D F, Holm, H, Stefansson, K & DBDS Genomic Consortium (MN part of consortium) 2021, ' Genetic insight into sick sinus syndrome ', European Heart Journal . https://doi.org/10.1093/eurheartj/ehaa1108
Thorolfsdottir, R B, Sveinbjornsson, G, Aegisdottir, H M, Benonisdottir, S, Stefansdottir, L, Ivarsdottir, E V, Halldorsson, G H, Sigurdsson, J K, Torp-Pedersen, C, Weeke, P E, Brunak, S, Westergaard, D, Pedersen, O B, Sorensen, E, Nielsen, K R, Burgdorf, K S, Banasik, K, Brumpton, B, Zhou, W, Oddsson, A, Tragante, V, Hjorleifsson, K E, Davidsson, O B, Rajamani, S, Jonsson, S, Torfason, B, Valgardsson, A S, Thorgeirsson, G, Frigge, M L, Thorleifsson, G, Norddahl, G L, Helgadottir, A, Gretarsdottir, S, Sulem, P, Jonsdottir, I, Willer, C J, Hveem, K, Bundgaard, H, Ullum, H, Arnar, D O, Thorsteinsdottir, U, Gudbjartsson, D F, Holm, H, Stefansson, K & DBDS Genomic Consortium 2021, ' Genetic insight into sick sinus syndrome ', European Heart Journal, vol. 42, no. 20, pp. 1959-1971 . https://doi.org/10.1093/eurheartj/ehaa1108
Thorolfsdottir, R B, Sveinbjornsson, G, Aegisdottir, H M, Benonisdottir, S, Stefansdottir, L, Ivarsdottir, E V, Halldorsson, G H, Sigurdsson, J K, Torp-Pedersen, C, Weeke, P E, Brunak, S, Westergaard, D, Pedersen, O B, Sørensen, E, Nielsen, K R, Burgdorf, K S, Banasik, K, Brumpton, B, Zhou, W, Oddsson, A, Tragante, V, Hjorleifsson, K E, Davidsson, O B, Rajamani, S, Jonsson, S, Torfason, B, Valgardsson, A S, Thorgeirsson, G, Frigge, M L, Thorleifsson, G, Norddahl, G L, Helgadottir, A, Gretarsdottir, S, Sulem, P, Jonsdottir, I, Willer, C J, Hveem, K, Bundgaard, H, Ullum, H, Arnar, D O, Thorsteinsdottir, U, Gudbjartsson, D F, Holm, H, Stefansson, K & DBDS Genomic Consortium 2021, ' Genetic insight into sick sinus syndrome ', European Heart Journal, vol. 42 . https://doi.org/10.1093/eurheartj/ehaa1108

Aims The aim of this study was to use human genetics to investigate the pathogenesis of sick sinus syndrome (SSS) and the role of risk factors in its development. Methods and results We performed a genome-wide association study of 6469 SSS cases and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd6e6818fe6f5016cfbb473965bbb2c2
https://pure.au.dk/ws/files/277444925/ehaa1108.pdf