Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Hildegard Keppeler"'
Autor:
Max Schumacher, Sina Beer, Emmanuelle Moraes Ribeiro, Fulya Korkmaz, Hildegard Keppeler, Rahel Fitzel, Estelle Erkner, Pia Radszuweit, Claudia Lengerke, Corina Schneidawind, Sebastian Hoefert, Paul Stefan Mauz, Dominik Schneidawind
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Locally advanced or metastatic head and neck squamous cell carcinoma (HNSCC) is associated with a poor prognosis. The introduction of PD-1 inhibitors has led to a significant improvement in survival, but only a subpopulation of patients responds to t
Externí odkaz:
https://doaj.org/article/d33f19f03c004d94af433713e6586503
Autor:
Anita Schmitt, Brigitte Neuber, Michael Schmitt, Melanie Märklin, Boris Klimovich, Claudia Lengerke, Emmanuelle Moraes Ribeiro, Kathy-Ann Secker, Ana-Maria Nitulescu, Rebekka Schairer, Hildegard Keppeler, Anton Wesle, Hannes Schmid, Daniela Chmiest, Silvia Podavini, Fulya Korkmaz, Corina Schneidawind, Dominik Schneidawind
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 1 (2024)
Background Relapse and graft-versus-host disease (GVHD) are the main causes of death after allogeneic hematopoietic cell transplantation (HCT). Preclinical murine models and clinical data suggest that invariant natural killer T (iNKT) cells prevent a
Externí odkaz:
https://doaj.org/article/2907d4c839b94d97ad13f309c1992704
Autor:
Rahel Fitzel, Kathy-Ann Secker-Grob, Hildegard Keppeler, Fulya Korkmaz, Rebekka Schairer, Estelle Erkner, Dominik Schneidawind, Claudia Lengerke, Thomas Hentrich, Julia M. Schulze-Hentrich, Corina Schneidawind
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 41, Iss , Pp 100902- (2023)
MLL rearranged (MLLr) leukemias are associated with a poor prognosis and a limited response to conventional therapies. Moreover, chemotherapies result in severe side effects with significant impairment of the immune system. Therefore, the identificat
Externí odkaz:
https://doaj.org/article/5a2bbb231dbd41e0b156cb49a9804d52
Autor:
Jacqueline Fischer, Estelle Erkner, Rahel Fitzel, Pia Radszuweit, Hildegard Keppeler, Fulya Korkmaz, Giovanni Roti, Claudia Lengerke, Dominik Schneidawind, Corina Schneidawind
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 19, p 14466 (2023)
MLL rearrangement (MLLr) is responsible for the development of acute leukemias with poor outcomes. Therefore, new therapeutic approaches are urgently needed. The NOTCH1 pathway plays a critical role in the pathogenesis of many cancers including acute
Externí odkaz:
https://doaj.org/article/141c8ec1797b428787335dc5fdca4e83
Autor:
Jakob Einhaus, Ann-Christin Pecher, Elisa Asteriti, Hannes Schmid, Kathy-Ann Secker, Silke Duerr-Stoerzer, Hildegard Keppeler, Reinhild Klein, Corina Schneidawind, Joerg Henes, Dominik Schneidawind
Publikováno v:
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-8 (2020)
Abstract Objective Systemic sclerosis (SSc) is a connective tissue disease with a significant morbidity and reduced survival of patients. Effective treatment and clinical control of the disease remain challenging. In particular, the development of pu
Externí odkaz:
https://doaj.org/article/27b4f8019cdc4954ac224882d2b9813f
Autor:
Ann-Christin Pecher, Felix Kettemann, Elisa Asteriti, Hannes Schmid, Silke Duerr-Stoerzer, Hildegard Keppeler, Joerg Christoph Henes, Reinhild Klein, Clemens Hinterleitner, Kathy-Ann Secker, Corina Schneidawind, Lothar Kanz, Dominik Schneidawind
Publikováno v:
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-8 (2019)
Abstract Background Systemic sclerosis (SSc) is a potentially fatal autoimmune disease that leads to extensive fibrosis of the skin and internal organs. Invariant natural killer T (iNKT) cells are potent immunoregulatory T lymphocytes being able to o
Externí odkaz:
https://doaj.org/article/53722ef4c96a400bad6afe83485331f1
Autor:
Hannes Schmid, Emmanuelle M. Ribeiro, Kathy-Ann Secker, Silke Duerr-Stoerzer, Hildegard Keppeler, Ruoyun Dong, Timo Munz, Klaus Schulze-Osthoff, Stephan Hailfinger, Corina Schneidawind, Dominik Schneidawind
Publikováno v:
Haematologica, Vol 107, Iss 2 (2021)
Graft-versus-host disease (GvHD) is a major cause of morbidity and mortality after allogeneic hematopoietic cell transplantation. We recently showed in murine studies and in vitro human models that adoptively transferred invariant natural killer T (i
Externí odkaz:
https://doaj.org/article/a686e7eee464476fa80c786a7985aa39
Autor:
Simona Jahnke, Hannes Schmid, Kathy-Ann Secker, Jakob Einhaus, Silke Duerr-Stoerzer, Hildegard Keppeler, Irmtraud Schober-Melms, Rebecca Baur, Michael Schumm, Rupert Handgretinger, Wolfgang Bethge, Lothar Kanz, Corina Schneidawind, Dominik Schneidawind
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Allogeneic hematopoietic cell transplantation (allo-HCT) is a curative treatment option for hematologic malignancies but relapse remains the most common cause of death. Infusion of donor lymphocytes (DLIs) can induce remission and prolong survival by
Externí odkaz:
https://doaj.org/article/408572c894f945a9803769e6512d431b
Autor:
Hannes Schmid, Corina Schneidawind, Simona Jahnke, Felix Kettemann, Kathy-Ann Secker, Silke Duerr-Stoerzer, Hildegard Keppeler, Lothar Kanz, Paul B. Savage, Dominik Schneidawind
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Graft-versus-host disease (GVHD) is a major cause of significant morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). Invariant natural killer T (iNKT) cells are potent regulators of immune responses, protect from lethal
Externí odkaz:
https://doaj.org/article/929130fb642c41e091a44c20381df024
Autor:
Gerhard E. Grossmayer, Hildegard Keppeler, Sebastian Boeltz, Christina Janko, Jürgen Rech, Martin Herrmann, Kirsten Lauber, Luis E. Muñoz
Publikováno v:
Frontiers in Immunology, Vol 8 (2018)
ObjectivesImpaired clearance of dying and dead cells by professional and amateur phagocytes plays a crucial role in the etiology of systemic lupus erythematosus (SLE). While dying, cells expose and release a plethora of eat-me and find-me signals to
Externí odkaz:
https://doaj.org/article/f461f04c635d4e719cc248a1c2bc4a5b