Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Hildegard I. D. Mack"'
Autor:
Sara Völkel, Thomas S. Tarawneh, Laura Sacher, Aditya M. Bhagwat, Ihab Karim, Hildegard I. D. Mack, Thomas Wiesmann, Björn Beutel, Joachim Hoyer, Christian Keller, Harald Renz, Andreas Burchert, Andreas Neubauer, Johannes Graumann, Chrysanthi Skevaki, Elisabeth K. M. Mack
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
BackgroundAcute respiratory distress syndrome (ARDS) in corona virus disease 19 (COVID-19) is triggered by hyperinflammation, thus providing a rationale for immunosuppressive treatments. The Janus kinase inhibitor Ruxolitinib (Ruxo) has shown efficac
Externí odkaz:
https://doaj.org/article/f31a8ac547bb49bca677652f2227fef4
Autor:
Hildegard I. D. Mack, Jennifer Kremer, Eva Albertini, Elisabeth K. M. Mack, Pidder Jansen-Dürr
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-11 (2022)
Abstract Background In the nematode Caenorhabditis elegans, longevity in response to germline ablation, but not in response to reduced insulin/IGF1-like signaling, is strongly dependent on the conserved protein kinase minibrain-related kinase 1 (MBK-
Externí odkaz:
https://doaj.org/article/16779b143bed49018c9c23449b902b92
Autor:
Hildegard I. D. Mack, Laura G. Buck, Sonja Skalet, Jennifer Kremer, Hao Li, Elisabeth K. M. Mack
Publikováno v:
Cells, Vol 11, Iss 22, p 3527 (2022)
Reduction of insulin/insulin-like growth factor 1 (IGF1) signaling (IIS) promotes longevity across species. In the nematode Caenorhabditis elegans, ablation of germline stem cells (GSCs) and activity changes of the conserved signaling mediators unc-4
Externí odkaz:
https://doaj.org/article/d912b26fa9b0409382be19a67f0eda6b
Autor:
Karl Munger, Hildegard I. D. Mack
Publikováno v:
Cells, Vol 1, Iss 3, Pp 204-247 (2012)
Autophagy is an intracellular degradation pathway for long-lived proteins and organelles. This process is activated above basal levels upon cell intrinsic or environmental stress and dysregulation of autophagy has been linked to various human disease
Externí odkaz:
https://doaj.org/article/01c320b44d0644d78ec38fd36420d312
Autor:
Thomas S. Tarawneh, Fiona R. Rodepeter, Julia Teply-Szymanski, Petra Ross, Vera Koch, Clemens Thölken, Jonas A. Schäfer, Niklas Gremke, Hildegard I. D. Mack, Judith Gold, Jorge Riera-Knorrenschild, Christian Wilhelm, Anja Rinke, Martin Middeke, Andreas Klemmer, Marcel Romey, Akira Hattesohl, Moritz Jesinghaus, Christian Görg, Jens Figiel, Ho-Ryun Chung, Thomas Wündisch, Andreas Neubauer, Carsten Denkert, Elisabeth K. M. Mack
Publikováno v:
Cancers; Volume 14; Issue 18; Pages: 4430
Background: Increasing knowledge of cancer biology and an expanding spectrum of molecularly targeted therapies provide the basis for precision oncology. Despite extensive gene diagnostics, previous reports indicate that less than 10% of patients bene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a153cc4881a3e57b245fe737d0268901
Autor:
Hildegard I. D. Mack, Jennifer Kremer, Eva Albertini, Elisabeth K. M. Mack, Pidder Jansen-Dürr
Publikováno v:
BMC Genomics
BMC Genomics, Vol 23, Iss 1, Pp 1-11 (2022)
BMC Genomics, Vol 23, Iss 1, Pp 1-11 (2022)
Background In the nematode Caenorhabditis elegans, longevity in response to germline ablation, but not in response to reduced insulin/IGF1-like signaling, is strongly dependent on the conserved protein kinase minibrain-related kinase 1 (MBK-1). In hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::593ad09a462e9ecad6c09159c5d71dd7
https://pubmed.ncbi.nlm.nih.gov/34983389
https://pubmed.ncbi.nlm.nih.gov/34983389
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 8, p e0220434 (2019)
PLoS ONE, Vol 14, Iss 8, p e0220434 (2019)
Human fumarylacetoacetate hydrolase (FAH) domain containing protein 1 (FAHD1) is a mitochondrial oxalocatate decarboxylase, the first of its kind identified in eukaryotes. The physiological role of FAHD1 in other eukaryotes is still poorly understood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f5500c8052b76bedd4ad39e2651d92f9
https://pubmed.ncbi.nlm.nih.gov/31412049
https://pubmed.ncbi.nlm.nih.gov/31412049
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0220434 (2019)
Human fumarylacetoacetate hydrolase (FAH) domain containing protein 1 (FAHD1) is a mitochondrial oxalocatate decarboxylase, the first of its kind identified in eukaryotes. The physiological role of FAHD1 in other eukaryotes is still poorly understood
Externí odkaz:
https://doaj.org/article/18befc3000004e1f98397155a70bf540