Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Hildegard C. Eliason"'
Autor:
Hildegard C. Eliason, Stephen A. Fakhoury, William J. Frazee, Steven M. Riddle, Bryan D. Marks
Publikováno v:
SLAS Discovery. 16:1247-1253
Developing molecularly targeted therapeutics with minimal off-target effects is facilitated by an understanding of compound selectivity. However, for HDAC inhibitors, a clear understanding of specificity has been challenging. In particular, it has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ae812ddd8ee17f996ef878fdf0bad0
https://doi.org/10.1177/1087057111422102
https://doi.org/10.1177/1087057111422102
Autor:
Krishne Gowda, Naveeda Qadir, Mary Szatkowski Ozers, Kerry M. Ervin, Kevin R. Kupcho, Bryan D. Marks, Mohammed Saleh Shekhani, Therese De Rosier, Hildegard C. Eliason, Steven M. Riddle
Publikováno v:
Biochemistry. 46:683-695
The interactions of the ligand binding domain (LBD) of androgen receptor (AR) and the AR T877A mutant, found in prostate cancer, with peptides from coactivator and corepressor proteins or random phage display peptides were investigated using in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc3c90814d4c9823706911db48b0af09
https://doi.org/10.1021/bi061321b
https://doi.org/10.1021/bi061321b
Autor:
Yi Gao, Kurt W. Vogel, Hildegard C. Eliason, Connie S. Lebakken, Steven M. Riddle, Laurie J. Reichling, Bryan D. Marks, W. Jack Frazee, Upinder Singh
Publikováno v:
Journal of biomolecular screening. 14(8)
The expansion of kinase assay technologies over the past decade has mirrored the growing interest in kinases as drug targets. As a result, there is no shortage of convenient, fluorescence-based methods available to assay targets that span the kinome.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a1d2776d73b22a4e5c18679a16a4850
https://pubmed.ncbi.nlm.nih.gov/19564447
https://pubmed.ncbi.nlm.nih.gov/19564447
Autor:
Sunita J. Shukla, Anton Simeonov, James Inglese, William J. Frazee, John Printen, Hildegard C. Eliason, Ryan MacArthur, Christopher P. Austin, Bryan D. Marks, Tina M. Hallis, Douglas S. Auld, Upinder Singh, Dac-Trung Nguyen
The human pregnane X nuclear receptor (PXR) is a xenobiotic-regulated receptor that is activated by a range of diverse chemicals, including antibiotics, antifungals, glucocorticoids, and herbal extracts. PXR has been characterized as an important rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a71bbfd9868b23ee45e6e3cee5ecf0
https://europepmc.org/articles/PMC3116688/
https://europepmc.org/articles/PMC3116688/
Autor:
Maya Fuerstenau-Sharp, David R. Piper, Steve Duff, Stephen D. Hess, Pam Whitney, Mohammed Saleh Shekhani, C. Jachec, W. Jack Frazee, Hildegard C. Eliason, Kurt W. Vogel, Bryan D. Marks, Elizabeth A. Frey, Brian A. Pollok, David V. Thompson
Publikováno v:
Assay and drug development technologies. 6(2)
The life-threatening consequences of acquired, or drug-induced, long QT syndrome due to block of the human ether-a-go-go-related gene (hERG) channel are well appreciated and have been the cause of several drugs being removed from the market in recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70cebf6643f4d2882c6f2b5a7fa437fa
https://pubmed.ncbi.nlm.nih.gov/18471075
https://pubmed.ncbi.nlm.nih.gov/18471075
Autor:
Kurt W. Vogel, Mohammed Saleh Shekhani, Bryan D. Marks, Hildegard C. Eliason, Naveeda Qadir, Klaus Doering
Publikováno v:
Assay and drug development technologies. 3(6)
Direct measurement of the fluorescence lifetime (FLT) of a fluorescent label is an emerging method for high-throughput screening. Changes in the fluorescence lifetime can be correlated to changes in the non-radiative relaxation pathway(s) for the exc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f1ec6018e2104efe68ac3e0390adf2
https://pubmed.ncbi.nlm.nih.gov/16438657
https://pubmed.ncbi.nlm.nih.gov/16438657
Autor:
Kevin L. Vedvik, Randy Hoffman, Kevin R. Kupcho, Hildegard C. Eliason, Kurt W. Vogel, Jasmin R. Gibson, Richard Somberg
Publikováno v:
Assay and drug development technologies. 2(2)
Kinase-mediated phosphorylation of proteins is critical to the regulation of many biological processes, including cell growth, apoptosis, and differentiation. Because of the central role that kinases play in processes that can lead to disease states,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::992e4feb6a81950ba356ad62f5107282
https://pubmed.ncbi.nlm.nih.gov/15165515
https://pubmed.ncbi.nlm.nih.gov/15165515
Publikováno v:
Cancer Research. 70:362-362
There is a great clinical need to develop selective, high affinity kinase inhibitors. While many high throughput kinase activity assays have become readily available, easy-to-use and cost-effective, activity-based assays have significant limitations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f24f06ad45fd40985c014a595ecd6bc9
https://doi.org/10.1158/1538-7445.am10-362
https://doi.org/10.1158/1538-7445.am10-362
Autor:
Sunita J. Shukla, Dac-Trung Nguyen, Ryan MacArthur, Anton Simeonov, William J. Frazee, Tina M. Hallis, Bryan D. Marks, Upinder Singh, Hildegard C. Eliason, John Printen, Christopher P. Austin, James Inglese, Douglas S. Auld
Publikováno v:
Assay & Drug Development Technologies; Apr2009, Vol. 7 Issue 2, p143-169, 27p
Autor:
David R. Piper, Steve R. Duff, Hildegard C. Eliason, W. Jack Frazee, Elizabeth A. Frey, Maya Fuerstenau-Sharp, Christine Jachec, Bryan D. Marks, Brian A. Pollok, Mohammed Saleh Shekhani, David V. Thompson, Pam Whitney, Kurt W. Vogel, Stephen D. Hess
Publikováno v:
Assay & Drug Development Technologies; Apr2008, Vol. 6 Issue 2, p213-223, 11p