Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Hildegard Buning"'
Autor:
Martin Bentler, Romain Hardet, Moritz Ertelt, Daniela Rudolf, Dorota Kaniowska, Andreas Schneider, Florian W.R. Vondran, Clara T. Schoeder, Marion Delphin, Julie Lucifora, Michael Ott, Ulrich T. Hacker, Sahil Adriouch, Hildegard Büning
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 30, Iss , Pp 576-592 (2023)
De novo immune responses are considered major challenges in gene therapy. With the aim to lower innate immune responses directly in cells targeted by adeno-associated virus (AAV) vectors, we equipped the vector capsid with a peptide known to interfer
Externí odkaz:
https://doaj.org/article/653f4c03268045f68435d394aae772b1
Autor:
Ann-Christin Franke, Romain Hardet, Lisa Prager, Martin Bentler, Mélanie Demeules, Philipp John-Neek, Nico Martin Jäschke, Teng Cheong Ha, Ulrich Thorsten Hacker, Sahil Adriouch, Hildegard Büning
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 238-253 (2023)
Immunotherapy has significantly improved treatment outcomes in various cancer entities. To enhance immunogenicity and efficacy, and to further broaden its applicability, co-administration of anti-tumor vaccines is considered as a promising strategy.
Externí odkaz:
https://doaj.org/article/60289b2c07f7465484685690b5e11a75
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/3bf1d7e36f2b41078d40c9e6bffc0c3e
Autor:
Daniel Stone, Nadja Meumann, Anne-Sophie Kuhlmann, Christopher W. Peterson, Hong Xie, Pavitra Roychoudhury, Michelle A. Loprieno, Xuan-Khang Vu, Daniel E. Strongin, Elizabeth J. Kenkel, Anoria Haick, Laurence Stensland, Willimark M. Obenza, Jacob Parrott, Veronica Nelson, Robert D. Murnane, Meei-Li Huang, Martine Aubert, Hans-Peter Kiem, Hildegard Büning, Keith R. Jerome
Publikováno v:
Hepatology Communications, Vol 7, Iss 2, Pp e0009-e0009 (2023)
Background and Aims:. Adeno-associated virus (AAV) vectors are widely used to deliver therapeutic transgenes to distinct tissues, including the liver. Vectors based on naturally occurring AAV serotypes as well as vectors using engineered capsids have
Externí odkaz:
https://doaj.org/article/1d40d622a45b4cc6aa011947303c4dea
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 437-438 (2023)
Externí odkaz:
https://doaj.org/article/07d7f1c80e3440f2abdc1adffa220f3a
Autor:
Elisa Murenu, Marina Pavlou, Lisa Richter, Kleopatra Rapti, Sabrina Just, Jasmina Cehajic-Kapetanovic, Neda Tafrishi, Andrew Hayes, Rachel Scholey, Robert Lucas, Hildegard Büning, Dirk Grimm, Stylianos Michalakis
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 587-600 (2021)
Inherited retinal dystrophies (IRDs) are characterized by progressive degeneration and loss of light-sensing photoreceptors. The most promising therapeutic approach for IRDs is gene supplementation therapy using viral vectors, which requires the pres
Externí odkaz:
https://doaj.org/article/37533d6c477c425d8123d2759419c7c9
Autor:
Marina Pavlou, Christian Schön, Laurence M Occelli, Axel Rossi, Nadja Meumann, Ryan F Boyd, Joshua T Bartoe, Jakob Siedlecki, Maximilian J Gerhardt, Sabrina Babutzka, Jacqueline Bogedein, Johanna E Wagner, Siegfried G Priglinger, Martin Biel, Simon M Petersen‐Jones, Hildegard Büning, Stylianos Michalakis
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 4, Pp 1-19 (2021)
Abstract Gene therapy using recombinant adeno‐associated virus (rAAV) vectors to treat blinding retinal dystrophies has become clinical reality. Therapeutically impactful targeting of photoreceptors still relies on subretinal vector delivery, which
Externí odkaz:
https://doaj.org/article/8b6c55ffca62471b9aed7b84bf31bc23
Autor:
Sereina O Sutter, Anouk Lkharrazi, Elisabeth M Schraner, Kevin Michaelsen, Anita Felicitas Meier, Jennifer Marx, Bernd Vogt, Hildegard Büning, Cornel Fraefel
Publikováno v:
PLoS Pathogens, Vol 18, Iss 7, p e1010187 (2022)
Nucleoli are membrane-less structures located within the nucleus and are known to be involved in many cellular functions, including stress response and cell cycle regulation. Besides, many viruses can employ the nucleolus or nucleolar proteins to pro
Externí odkaz:
https://doaj.org/article/1a2d5a0947f944dcb06d6d884bcbc3df
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Cancer remains the second most common cause of death worldwide affecting around 10 million patients every year. Among the therapeutic options, chemotherapeutic drugs are widely used but often associated with side effects. In addition, toxicity agains
Externí odkaz:
https://doaj.org/article/92d156eaea2e41a3abe500f63393b19e