Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Hildegard Boss"'
Autor:
Mateva Liudmila, Corinne Emotte, George Golor, Richard A. Preston, Yves Horsmans, Henry Castro, Jocelyn Zhou, Oren Shibolet, Dalila Sellami, Michelle Quinlan, Hildegard Boss
Publikováno v:
Clinical Pharmacokinetics. 57:345-354
Sonidegib is a potent, selective and orally bioavailable inhibitor of the Hedgehog signaling pathway, primarily metabolized by the liver. In order to make dose recommendations for patients with hepatic impairment, we have assessed here the pharmacoki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a52c1fecab7d250f30050898e6af21
https://doi.org/10.1007/s40262-017-0560-2
https://doi.org/10.1007/s40262-017-0560-2
Autor:
Michelle Quinlan, Franck Picard, Dalila Sellami, Hildegard Boss, Jocelyn Zhou, Henry Castro, Kelli J Glenn
Publikováno v:
British Journal of Clinical Pharmacology. 82:1022-1029
Aims This study aimed to evaluate the impact of esomeprazole on the pharmacokinetics of sonidegib. Methods This Phase I study evaluated the impact of the proton pump inhibitor (PPI) esomeprazole on the oral absorption and pharmacokinetics (PKs) of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a67a37c060160d7cc0717ecd9e70a94c
https://doi.org/10.1111/bcp.13038
https://doi.org/10.1111/bcp.13038
Autor:
Jocelyn, Zhou, Michelle, Quinlan, Kelli, Glenn, Hildegard, Boss, Franck, Picard, Henry, Castro, Dalila, Sellami
Publikováno v:
British journal of clinical pharmacology. 82(4)
This study aimed to evaluate the impact of esomeprazole on the pharmacokinetics of sonidegib.This Phase I study evaluated the impact of the proton pump inhibitor (PPI) esomeprazole on the oral absorption and pharmacokinetics (PKs) of a single dose of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::87e1e7ea4b7ed1a5ff365dc931ddcc49
https://pubmed.ncbi.nlm.nih.gov/27277189
https://pubmed.ncbi.nlm.nih.gov/27277189
Autor:
Hildegard Boss, Søren Lophaven, Sophie Skorjanec, Thomas Delvin, Hans G. Kress, Michael Marx, Thomas Wagner, Gezim Lahu
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 75:225-231
Aim The pharmacokinetic profiles of the two commercially available transdermal fentanyl patches Matrifen (100 microg/h) and Durogesic DTrans (100 microg/h), used to manage severe chronic pain, were compared regarding their systemic exposure, rate of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86fc41d9a2dfafaff96f30bc16a09027
https://doi.org/10.1016/j.ejpb.2010.02.005
https://doi.org/10.1016/j.ejpb.2010.02.005
Autor:
Hildegard Boss, Kirsten M. Bommele, Armin Hatzelmann, Geert Jan Sterk, Margaretha Van Der Mey, Hendrik Timmerman, Mike Van Slingerland
Publikováno v:
Journal of Medicinal Chemistry. 46:2008-2016
In this study, the synthesis and in vitro and in vivo pharmacological investigations of a new series of phthalazinone/pyridazinone hybrids with both PDE3 and PDE4 inhibitory activities are described. These compounds combine the pharmacophores of rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4d046689594c30558075b30088f2ea1
https://doi.org/10.1021/jm030776l
https://doi.org/10.1021/jm030776l
Autor:
Hildegard Boss, Ivonne J. Van Der Laan, Hendrik Timmerman, Geert Jan Sterk, Armin Hatzelmann, Margaretha Van Der Mey
Publikováno v:
Journal of Medicinal Chemistry. 45:2520-2525
The synthesis and biological activities of a series of N-substituted cis-4a,5,6,7,8,8a-hexa- and cis-4a,5,8,8a-tetrahydro-2H-phthalazin-1-ones are described. It was found that compounds bearing a cycloalkyl group at the 2-position exhibit the highest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b69133d0f7480c4abc1c8d2ca2003cf1
https://doi.org/10.1021/jm0110340
https://doi.org/10.1021/jm0110340
Autor:
Michael Przybylski, S. Haas, Rainer Boer, Volker Gekeler, Angelika Schödl, Hildegard Boss, C Borchers, Wolf-Rüdiger Ulrich
Publikováno v:
European Journal of Pharmacology. 295:253-260
The interaction of cytostatics and chemosensitizers with the dexniguldipine binding site of P-glycoprotein was investigated in photoaffinity labeling experiments. A tritiated azidoderivative of the chemosensitizer dexniguldipine with dihydropyridine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58e7807dc8c6c38450a5a467d4c80f80
https://doi.org/10.1016/0014-2999(95)00649-4
https://doi.org/10.1016/0014-2999(95)00649-4
Autor:
Teresa Macarulla, Daniel H. Palmer, Wu Yi, Eunice L. Kwak, Josep Tabernero, Hildegard Boss, Jocelyn Zhou, Sunil Sharma, Kenneth H. Yu, Dalila Sellami
Publikováno v:
Journal of Clinical Oncology. 34:371-371
371 Background: Sonidegib (LDE225) is a potent, selective, and orally bioavailable inhibitor of smoothened receptor that demonstrated preclinical activity in combination with gemcitabine (GEM). Here, we present data from a phase 1b trial of sonidegib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba2b05efc256f4fda9df6aedc769f046
https://doi.org/10.1200/jco.2016.34.4_suppl.371
https://doi.org/10.1200/jco.2016.34.4_suppl.371
Autor:
Hildegard Boss, Pramod Niphadkar, Kannivelu Jagannath, S. Hellbardt, Nilkanth Awad, Durga A. Gadgil, Jyotsna M. Joshi
Publikováno v:
Clinical therapeutics. 27(11)
Objective: The efficacy of ciclesonide 160 μg QD (given either in the morning or evening) was compared with budesonide 200 μg BID in adults with stable asthma that was pretreated with inhaled corticosteroids. Methods: This was a randomized, 3-arm,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::868632cbe8eded309d5caddb3a0adda4
https://pubmed.ncbi.nlm.nih.gov/16368446
https://pubmed.ncbi.nlm.nih.gov/16368446
Autor:
Hendrik Timmerman, Hildegard Boss, Margaretha Van der Mey, Geert Jan Sterk, Kees Goubitz, Armin Hatzelmann, Henk Schenk, Dennis Couwenberg
Publikováno v:
Journal of Medicinal Chemistry, 45, 2526-33. American Chemical Society
der Van Mey, M, Boss, H, Couwenberg, D, Hatzelmann, A, Sterk, G J, Goubitz, K, Schenk, H & Timmerman, H 2002, ' Novel selective phosphodiesterase (PDE4) inhibitors. 4. Resolution, absolute configuration, and PDE4 inhibitory activity of cis-tetra-and cis-hexahydrophthalazinones ', Journal of Medicinal Chemistry, vol. 45, pp. 2526-33 . https://doi.org/10.1021/jm0110338
Journal of Medicinal Chemistry, 45, 2526-2533. American Chemical Society
der Van Mey, M, Boss, H, Couwenberg, D, Hatzelmann, A, Sterk, G J, Goubitz, K, Schenk, H & Timmerman, H 2002, ' Novel selective phosphodiesterase (PDE4) inhibitors. 4. Resolution, absolute configuration, and PDE4 inhibitory activity of cis-tetra-and cis-hexahydrophthalazinones ', Journal of Medicinal Chemistry, vol. 45, pp. 2526-33 . https://doi.org/10.1021/jm0110338
Journal of Medicinal Chemistry, 45, 2526-2533. American Chemical Society
Recently, we reported that 4-catechol-substituted cis-(+/-)-4a,5,6,7,8,8a-hexa- and cis-(+/-)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-ones show potent inhibition of phosphodiesterase (PDE4) activity, while the corresponding trans racemic mixtures exhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee8ea68cc0940f988663a1ef1f6e0417
https://research.vu.nl/en/publications/2fdf851e-0f3d-4310-8869-80246845a738
https://research.vu.nl/en/publications/2fdf851e-0f3d-4310-8869-80246845a738
