Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Hilde van Hattum"'
Publikováno v:
Journal of the American Society for Mass Spectrometry. 28:190-199
Hexafluoroisopropanol (HFIP) has been widely used as an acidic modifier for mobile phases for liquid chromatography-mass spectrometry (LC-MS) analysis of oligonucleotides ever since the first report of its use for this purpose. This is not surprising
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3845a04b00e8938398fc9d08248d5ecf
https://doi.org/10.1007/s13361-016-1500-3
https://doi.org/10.1007/s13361-016-1500-3
Autor:
Herbert Waldmann, Hilde van Hattum
Publikováno v:
Journal of the American Chemical Society. 136:11853-11859
For scientists to gain a better understanding of nature, biological research is greatly aided by small-molecule modulators that perturb protein activity without fundamentally altering the underlying biological systems. The number of possible interfer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7521c97663ddc03c4de50109199285a1
https://doi.org/10.1021/ja505861d
https://doi.org/10.1021/ja505861d
Autor:
Ed E. Moret, Hilbert M. Branderhorst, Hilde van Hattum, Ulf J. Nilsson, Roland J. Pieters, Hakon Leffler
Publikováno v:
Journal of Medicinal Chemistry; Vol 56
Inhibitors for galectin-1 and -3 were synthesized from thiodigalactoside and lactosamine by derivatization of the galactose C3. Introduction of 4-phenyl-1H-1,2,3-triazol-1-yl substituents at the thiodigalactoside C3 by CuAAC, targeting arginine–are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f055cd00be845ff1e096cc41d34a06
Autor:
Bader A. Salameh, Hans Thalsgaard Schambye, Santanu Mandal, Gunjan Sharma, Ulf J. Nilsson, Alison C. MacKinnon, John Stegmayr, Monique van Scherpenzeel, Amaia Larumbe, P.M. Collins, Vishal Kumar Rajput, Barbro Kahl-Knutsson, Tariq Sethi, Hilde van Hattum, Ian Cumpstey, Roland J. Pieters, Tamara Delaine, Hakon Leffler, Stina Oredsson, Helen Blanchard
Publikováno v:
ChemBioChem; 17(18), pp 1759-1770 (2016)
ChemBioChem, 17, 18, pp. 1759-1770
ChemBioChem, 17, 1759-1770
Delaine, T, Collins, P, MacKinnon, A, Sharma, G, Stegmayr, J, Rajput, V K, Mandal, S, Cumpstey, I, Larumbe, A, Salameh, B A, Kahl-Knutsson, B, van Hattum, H, van Scherpenzeel, M, Pieters, R J, Sethi, T, Schambye, H, Oredsson, S, Leffler, H, Blanchard, H & Nilsson, U J 2016, ' Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition ', ChemBioChem . https://doi.org/10.1002/cbic.201600285
ChemBioChem, 17, 18, pp. 1759-1770
ChemBioChem, 17, 1759-1770
Delaine, T, Collins, P, MacKinnon, A, Sharma, G, Stegmayr, J, Rajput, V K, Mandal, S, Cumpstey, I, Larumbe, A, Salameh, B A, Kahl-Knutsson, B, van Hattum, H, van Scherpenzeel, M, Pieters, R J, Sethi, T, Schambye, H, Oredsson, S, Leffler, H, Blanchard, H & Nilsson, U J 2016, ' Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition ', ChemBioChem . https://doi.org/10.1002/cbic.201600285
Discovery of glycan-competitive galectin-3-binding compounds that attenuate lung fibrosis in a murine model and that block intracellular galectin-3 accumulation at damaged vesicles, hence revealing galectin-3-glycan interactions involved in fibrosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbaa90d856d56ee08728755713b58e08
https://pubmed.ncbi.nlm.nih.gov/27356186
https://pubmed.ncbi.nlm.nih.gov/27356186
Autor:
Jos P. M. van Putten, Hilde van Hattum, Kim van der Zwaluw, Gerben M. Visser, Roland J. Pieters, Rob Ruijtenbeek
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(24)
A functional detection assay was developed for Escherichia coli secreted shiga-like toxin based on antibody capture and visualization with a multivalent galabiose ligand. It was possible to detect verotoxin in medically relevant E. coli samples in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f12cb69df72ce74d114afc6b89518feb
https://pubmed.ncbi.nlm.nih.gov/23142616
https://pubmed.ncbi.nlm.nih.gov/23142616
Publikováno v:
Cancer Research. 73:4136-4136
The galectin protein family consists of fifteen galactoside-binding proteins that are present in all classes of life where they function as cell-cell and cell-matrix interaction mediators. Galectins are however also highly overexpressed in various pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc9e39138cfea8d39491c54257fcb934
https://doi.org/10.1158/1538-7445.am2013-4136
https://doi.org/10.1158/1538-7445.am2013-4136
Autor:
Herbert Waldmann, Hilde van Hattum
Publikováno v:
Chemistry & Biology. (9):1185-1195
Rat sarcoma (RAS) family members are small GTPases that control a number of signaling pathways important for normal cellular proliferation. Therefore, it is no surprise that a significant portion of human tumors express constitutively active mutated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3626183041a62b2484b89cd2618b386