Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Hilde van Hattum"'
Publikováno v:
Journal of the American Society for Mass Spectrometry. 28:190-199
Hexafluoroisopropanol (HFIP) has been widely used as an acidic modifier for mobile phases for liquid chromatography-mass spectrometry (LC-MS) analysis of oligonucleotides ever since the first report of its use for this purpose. This is not surprising
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3845a04b00e8938398fc9d08248d5ecf
https://doi.org/10.1007/s13361-016-1500-3
https://doi.org/10.1007/s13361-016-1500-3
Autor:
Herbert Waldmann, Hilde van Hattum
Publikováno v:
Journal of the American Chemical Society. 136:11853-11859
For scientists to gain a better understanding of nature, biological research is greatly aided by small-molecule modulators that perturb protein activity without fundamentally altering the underlying biological systems. The number of possible interfer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7521c97663ddc03c4de50109199285a1
https://doi.org/10.1021/ja505861d
https://doi.org/10.1021/ja505861d
Autor:
Ed E. Moret, Hilbert M. Branderhorst, Hilde van Hattum, Ulf J. Nilsson, Roland J. Pieters, Hakon Leffler
Publikováno v:
Journal of Medicinal Chemistry; Vol 56
Inhibitors for galectin-1 and -3 were synthesized from thiodigalactoside and lactosamine by derivatization of the galactose C3. Introduction of 4-phenyl-1H-1,2,3-triazol-1-yl substituents at the thiodigalactoside C3 by CuAAC, targeting arginine–are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f055cd00be845ff1e096cc41d34a06
Autor:
Bader A. Salameh, Hans Thalsgaard Schambye, Santanu Mandal, Gunjan Sharma, Ulf J. Nilsson, Alison C. MacKinnon, John Stegmayr, Monique van Scherpenzeel, Amaia Larumbe, P.M. Collins, Vishal Kumar Rajput, Barbro Kahl-Knutsson, Tariq Sethi, Hilde van Hattum, Ian Cumpstey, Roland J. Pieters, Tamara Delaine, Hakon Leffler, Stina Oredsson, Helen Blanchard
Publikováno v:
ChemBioChem; 17(18), pp 1759-1770 (2016)
ChemBioChem, 17, 18, pp. 1759-1770
ChemBioChem, 17, 1759-1770
Delaine, T, Collins, P, MacKinnon, A, Sharma, G, Stegmayr, J, Rajput, V K, Mandal, S, Cumpstey, I, Larumbe, A, Salameh, B A, Kahl-Knutsson, B, van Hattum, H, van Scherpenzeel, M, Pieters, R J, Sethi, T, Schambye, H, Oredsson, S, Leffler, H, Blanchard, H & Nilsson, U J 2016, ' Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition ', ChemBioChem . https://doi.org/10.1002/cbic.201600285
ChemBioChem, 17, 18, pp. 1759-1770
ChemBioChem, 17, 1759-1770
Delaine, T, Collins, P, MacKinnon, A, Sharma, G, Stegmayr, J, Rajput, V K, Mandal, S, Cumpstey, I, Larumbe, A, Salameh, B A, Kahl-Knutsson, B, van Hattum, H, van Scherpenzeel, M, Pieters, R J, Sethi, T, Schambye, H, Oredsson, S, Leffler, H, Blanchard, H & Nilsson, U J 2016, ' Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition ', ChemBioChem . https://doi.org/10.1002/cbic.201600285
Discovery of glycan-competitive galectin-3-binding compounds that attenuate lung fibrosis in a murine model and that block intracellular galectin-3 accumulation at damaged vesicles, hence revealing galectin-3-glycan interactions involved in fibrosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbaa90d856d56ee08728755713b58e08
https://pubmed.ncbi.nlm.nih.gov/27356186
https://pubmed.ncbi.nlm.nih.gov/27356186
Autor:
Jos P. M. van Putten, Hilde van Hattum, Kim van der Zwaluw, Gerben M. Visser, Roland J. Pieters, Rob Ruijtenbeek
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(24)
A functional detection assay was developed for Escherichia coli secreted shiga-like toxin based on antibody capture and visualization with a multivalent galabiose ligand. It was possible to detect verotoxin in medically relevant E. coli samples in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f12cb69df72ce74d114afc6b89518feb
https://pubmed.ncbi.nlm.nih.gov/23142616
https://pubmed.ncbi.nlm.nih.gov/23142616
Publikováno v:
Cancer Research. 73:4136-4136
The galectin protein family consists of fifteen galactoside-binding proteins that are present in all classes of life where they function as cell-cell and cell-matrix interaction mediators. Galectins are however also highly overexpressed in various pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc9e39138cfea8d39491c54257fcb934
https://doi.org/10.1158/1538-7445.am2013-4136
https://doi.org/10.1158/1538-7445.am2013-4136
Autor:
Herbert Waldmann, Hilde van Hattum
Publikováno v:
Chemistry & Biology. (9):1185-1195
Rat sarcoma (RAS) family members are small GTPases that control a number of signaling pathways important for normal cellular proliferation. Therefore, it is no surprise that a significant portion of human tumors express constitutively active mutated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3626183041a62b2484b89cd2618b386
Autor:
Brinks, Vera, Lipinska, Katarzyna, de Jager, Miranda, Beumer, Wouter, Button, Brian, Livraghi-Butrico, Alessandra, Henig, Noreen, Matthee, Bianca
Publikováno v:
Journal of Aerosol Medicine & Pulmonary Drug Delivery; Oct2019, Vol. 32 Issue 5, p303-316, 14p
Autor:
Delaine, Tamara, Collins, Patrick, MacKinnon, Alison, Sharma, G., Stegmayr, John, Rajput, Vishal K., Mandal, Santanu, Cumpstey, Ian, Larumbe, Amaia, Salameh, Bader A., Kahl‐Knutsson, Barbro, van Hattum, Hilde, van Scherpenzeel, Monique, Pieters, Roland J., Sethi, Tariq, Schambye, Hans, Oredsson, Stina, Leffler, Hakon, Blanchard, Helen, Nilsson, Ulf J.
Publikováno v:
ChemBioChem; 9/15/2016, Vol. 17 Issue 18, p1759-1770, 12p
Publikováno v:
ChemBioChem; 11/23/2015, Vol. 16 Issue 17, p2460-2465, 6p, 3 Diagrams, 1 Chart, 1 Graph