Polyglutamine expansion accelerates the dynamics of ataxin-1 and does not result in aggregate formation

Autor: Eric Reits, Przemek M. Krawczyk, Hilde A. Krol, Jacob A. Aten, Klazien S. Bosch, Elly M. Hol

Publikováno v: PLoS ONE, Vol 3, Iss 1, p e1503 (2008)
PLoS One, 3. Public Library of Science
PLoS ONE, 3(1). Public Library of Science
PLoS ONE

BackgroundPolyglutamine expansion disorders are caused by an expansion of the polyglutamine (polyQ) tract in the disease related protein, leading to severe neurodegeneration. All polyQ disorders are hallmarked by the presence of intracellular aggrega

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59680a42f16c7e41775b714a974427b5
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18231590/pdf/?tool=EBI