Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Hilde Ween"'
Autor:
Clark A. Briggs, Jens Halvard Grønlien, Kirsten Thorin-Hagene, Steven Cassar, John Malysz, Hilde Ween, Murali Gopalakrishnan, Jinhe Li
Publikováno v:
European Journal of Pharmacology. 647:37-47
Genistein and 5-hydroxyindole (5-HI) potentiate the α7 nicotinic acetylcholine receptor current by primarily increasing peak amplitude, a property of type I α7 positive allosteric modulation. In this study, the effects of these two compounds were i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ecf788748d420de7ab25bd701e7a6ba
https://doi.org/10.1016/j.ejphar.2010.08.027
https://doi.org/10.1016/j.ejphar.2010.08.027
Autor:
Murali Gopalakrishnan, Jens Halvard Grønlien, Hilde Ween, John Malysz, Kirsten Thorin-Hagene, Chih-Hung Lee, Elisabeth Andersen
Publikováno v:
Neurochemistry International. 57:269-277
Alpha3-containing (alpha 3*) and alpha 7 nicotinic acetylcholine receptors (nAChRs) are expressed in human IMR-32 neuroblastoma cells and implicated in Ca(2+) signaling. In this study, we investigated the intracellular Ca(2+) transient generation evo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16bf1b1d6e70135dd727caac9bdea68d
https://doi.org/10.1016/j.neuint.2010.06.005
https://doi.org/10.1016/j.neuint.2010.06.005
Autor:
Jinhe Li, David J. Anderson, Clark A. Briggs, Sujatha M. Gopalakrishnan, Earl J. Gubbins, Tino Dyhring, Elsebet Ø. Nielsen, John Malysz, Kirten Thorin-Hagene, Min Hu, William H. Bunnelle, Daniel B. Timmermann, Jens Halvard Grønlien, Michael Meyer, Jianguo Ji, Murali Gopalakrishnan, Dan Peters, Pamela S. Puttfarcken, Hilde Ween, Rosalind J. Helfrich, Philip K. Ahring, Monika Håkerud
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 334:863-874
Enhancement of alpha7 nicotinic acetylcholine receptor (nAChR) activity is considered a therapeutic approach for ameliorating cognitive deficits present in Alzheimer's disease and schizophrenia. In this study, we describe the in vitro profile of a no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a6038ab03c9504a39d27e70d0187e2
https://doi.org/10.1124/jpet.110.167072
https://doi.org/10.1124/jpet.110.167072
Role of channel activation in cognitive enhancement mediated by α7 nicotinic acetylcholine receptors
Autor:
William H. Bunnelle, Tino Dyhring, Jens Halvard Grønlien, David J. Anderson, Peter Curzon, John Malysz, Gunnar M. Olsen, Kirsten Thorin-Hagene, Clark A. Briggs, Paige Kerr, Hilde Ween, Murali Gopalakrishnan, Daniel B. Timmermann, Dan Peters
Publikováno v:
British Journal of Pharmacology. 158:1486-1494
Background and purpose: Several agonists of the α7 nicotinic acetylcholine receptor (nAChR) have been developed for treatment of cognitive deficits. However, agonist efficacy in vivo is difficult to reconcile with rapid α7 nAChR desensitization in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e03e70550bb60426e0c0a2ef38dbb934
https://doi.org/10.1111/j.1476-5381.2009.00426.x
https://doi.org/10.1111/j.1476-5381.2009.00426.x
Autor:
Jennifer M. Frost, Marc J. C. Scanio, Jens Halvard Grønlien, Jianguo Ji, Tao Li, Kirsten Thorin-Hagene, William H. Bunnelle, Hilde Ween, David J. Anderson, Lei Shi, Michael Meyer, Tino Dyhring, Karin R. Tietje, Dan Peters
Publikováno v:
Journal of Medicinal Chemistry. 52:4126-4141
A series of 5-(pyridine-3-yl)octahydropyrrolo[3,4-c]pyrroles have been prepared that exhibit high affinity to alpha4beta2 and/or alpha7 nicotinic acetylcholine receptors (nAChRs). Simple substitution patterns have been identified that allow construct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f95edc1f13156802b50953a488364939
https://doi.org/10.1021/jm900249k
https://doi.org/10.1021/jm900249k
Autor:
Kathy Sarris, Clark A. Briggs, Gregory A. Gfesser, William H. Bunnelle, Sujatha M. Gopalakrishnan, Michael P. Curtis, Caroline Wetterstrand, Ramin Faghih, Richard J. Radek, John Malysz, Holly M. Robb, Jens Halvard Grønlien, Hilde Ween, Kennan C. Marsh, Rachid El-Kouhen, Murali Gopalakrishnan
Publikováno v:
Journal of Medicinal Chemistry. 52:3377-3384
The discovery of a series of pyrrole-sulfonamides as positive allosteric modulators (PAM) of alpha7 nAChRs is described. Optimization of this series led to the identification of 19 (A-867744), a novel type II PAM with good potency and selectivity. Co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d26e322c761752b465f16f2e130987ba
https://doi.org/10.1021/jm9003818
https://doi.org/10.1021/jm9003818
Autor:
Caroline Wetterstrand, Kirsten Thorin-Hagene, Ramin Faghih, John Malysz, Monika Håkerud, William H. Bunnelle, Jens Halvard Grønlien, Murali Gopalakrishnan, David J. Anderson, Hilde Ween, Clark A. Briggs
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 330:257-267
Targeting alpha7 neuronal acetylcholine receptors (nAChRs) with selective agonists and positive allosteric modulators (PAMs) is considered a therapeutic approach for managing cognitive deficits in schizophrenia and Alzheimer's disease. In this study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4306505e22b1d2ba56d85783008aa593
https://doi.org/10.1124/jpet.109.151886
https://doi.org/10.1124/jpet.109.151886
Autor:
William H. Bunnelle, Earl J. Gubbins, Murali Gopalakrishnan, Jens Halvard Grønlien, Kirsten Thorin-Hagene, Hilde Ween, David J. Anderson, John Malysz, Clark A. Briggs, Monika Håkerud, M R Schrimpf, Michael Meyer, Jinhe Li
Publikováno v:
British Journal of Pharmacology. 153:1054-1061
Background and purpose: The α7 nicotinic acetylcholine receptor (nAChR) has attracted considerable interest as a target for cognitive enhancement in schizophrenia and Alzheimer's Disease. However, most recently described α7 agonists are derived fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7a61107c884fbd3e037591cb925e643
https://doi.org/10.1038/sj.bjp.0707649
https://doi.org/10.1038/sj.bjp.0707649
Autor:
Kaitlin E. Browman, Arthur L. Nikkel, Richard Harris, Monika Håkerud, William H. Bunnelle, Paul J. Brackemeyer, David J. Anderson, Jennifer M. Frost, Sabine Halm, Jens Halvard Grønlien, Eva Spies, Liping Pan, Eric A.G. Blomme, Clark A. Briggs, Rosalind J. Helfrich, Ryan M. Fryer, Karla Drescher, Earl J. Gubbins, R. Scott Bitner, Ruth L. Martin, Kennan C. Marsh, Kirsten Thorin-Hagene, Stephani Otte, Peter Curzon, Murali Gopalakrishnan, John Malysz, Michael Meyer, Devalina Law, Gerard B. Fox, Hilde Ween, Dagmar Bury, Karin R. Tietje, Hongyu Xu, Pamela S. Puttfarcken, Angela L. Molesky, Kathy L. Kohlhaas, Holly M. Robb, Jeffrey F. Waring, Richard J. Radek
Publikováno v:
CNS Drug Reviews. 14:65-82
Among the diverse sets of nicotinic acetylcholine receptors (nAChRs), the alpha7 subtype is highly expressed in the hippocampus and cortex and is thought to play important roles in a variety of cognitive processes. In this review, we describe the pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a77948a51c5747ec1fd7e59fc278d27f
https://doi.org/10.1111/j.1527-3458.2008.00037.x
https://doi.org/10.1111/j.1527-3458.2008.00037.x
Autor:
Clark A, Briggs, Jens Halvard, Grønlien, Peter, Curzon, Daniel B, Timmermann, Hilde, Ween, Kirsten, Thorin-Hagene, Paige, Kerr, David J, Anderson, John, Malysz, Tino, Dyhring, Gunnar M, Olsen, Dan, Peters, William H, Bunnelle, Murali, Gopalakrishnan
Publikováno v:
British journal of pharmacology. 158(6)
Several agonists of the alpha7 nicotinic acetylcholine receptor (nAChR) have been developed for treatment of cognitive deficits. However, agonist efficacy in vivo is difficult to reconcile with rapid alpha7 nAChR desensitization in vitro; and further
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::806c3fef70e4b6903d9063ad93506315
https://pubmed.ncbi.nlm.nih.gov/19845675
https://pubmed.ncbi.nlm.nih.gov/19845675