Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Hilde, Nilsen"'
Autor:
Giorgio Turconi, Farhan Alam, Tanima SenGupta, Sini Pirnes-Karhu, Soophie Olfat, Mark S. Schmidt, Kärt Mätlik, Ana Montaño-Rodriguez, Vladimir Heiskanen, Daniel Garton, Petteri T. Piepponen, Charles Brenner, Carina I. Holmberg, Hilde Nilsen, Eija Pirinen, Jaan-Olle Andressoo
Publikováno v:
Heliyon, Vol 10, Iss 14, Pp e34355- (2024)
Parkinson's disease (PD) is associated with a reduction in 26/20S proteasome and mitochondrial function and depletion of dopamine. Activation of mitochondrial function with the NAD+ precursor nicotinamide riboside (NR) is a potential therapeutic for
Externí odkaz:
https://doaj.org/article/ac4f73d8f115461db81a3d5dd4a624da
Autor:
Christian Prebensen, Yohan Lefol, Peder L. Myhre, Torben Lüders, Christine Jonassen, Anita Blomfeldt, Torbjørn Omland, Hilde Nilsen, Jan-Erik Berdal
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract A maladaptive inflammatory response has been implicated in the pathogenesis of severe COVID-19. This study aimed to characterize the temporal dynamics of this response and investigate whether severe disease is associated with distinct gene e
Externí odkaz:
https://doaj.org/article/617d97c99f92420c82df8ad5c983e5c9
Autor:
Alfonso Schiavi, Eva Salveridou, Vanessa Brinkmann, Anjumara Shaik, Ralph Menzel, Sumana Kalyanasundaram, Ståle Nygård, Hilde Nilsen, Natascia Ventura
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106448- (2023)
Summary: Excessive iron accumulation or deficiency leads to a variety of pathologies in humans and developmental arrest in the nematode Caenorhabditis elegans. Instead, sub-lethal iron depletion extends C. elegans lifespan. Hypoxia preconditioning pr
Externí odkaz:
https://doaj.org/article/718e9a6fdb4d42a78172e8de69e26027
Autor:
Christian Prebensen, Yohan Lefol, Peder L. Myhre, Torben Lüders, Christine Jonassen, Anita Blomfeldt, Torbjørn Omland, Hilde Nilsen, Jan‑Erik Berdal
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/4aebf080d513416a83ca80ee0d0c36ce
Autor:
Ahmad Sleiman, Kévin Lalanne, François Vianna, Yann Perrot, Myriam Richaud, Tanima SenGupta, Mikaël Cardot-Martin, Pascal Pedini, Christophe Picard, Hilde Nilsen, Simon Galas, Christelle Adam-Guillermin
Publikováno v:
Biology, Vol 12, Iss 6, p 839 (2023)
Fifty percent of all patients with cancer worldwide require radiotherapy. In the case of brain tumors, despite the improvement in the precision of radiation delivery with proton therapy, studies have shown structural and functional changes in the bra
Externí odkaz:
https://doaj.org/article/3182eadfa0264612a92db8fff7bfe9b1
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101264- (2022)
Summary: Transgenic Caenorhabditis elegans that expresses the full-length wild-type human α-synuclein in dopaminergic neurons provides a well-established Parkinson’s disease (PD) nematode model. Here, we present a detailed protocol to monitor and
Externí odkaz:
https://doaj.org/article/c5ae3ab080fd4347a5dbcb8dc957a4b4
Autor:
Tom Rune Karlsen, Maria B. Olsen, Xiang Y. Kong, Kuan Yang, Ana Quiles-Jiménez, Penelope Kroustallaki, Sverre Holm, Glenn Terje Lines, Pål Aukrust, Tonje Skarpengland, Magnar Bjørås, Tuva B. Dahl, Hilde Nilsen, Ida Gregersen, Bente Halvorsen
Publikováno v:
Biochemistry and Biophysics Reports, Vol 29, Iss , Pp 101211- (2022)
Deficiency of NEIL3, a DNA repair enzyme, has significant impact on mouse physiology, including vascular biology and gut health, processes related to aging. Leukocyte telomere length (LTL) is suggested as a marker of biological aging, and shortened L
Externí odkaz:
https://doaj.org/article/652a13954c3c4aab96d85fa43546c2e4
Autor:
Marina Alexeeva, Marivi Nabong Moen, Xiang Ming Xu, Anette Rasmussen, Ingar Leiros, Finn Kirpekar, Arne Klungland, Lene Alsøe, Hilde Nilsen, Svein Bjelland
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Uracil arises in cellular DNA by cytosine (C) deamination and erroneous replicative incorporation of deoxyuridine monophosphate opposite adenine. The former generates C → thymine transition mutations if uracil is not removed by uracil-DNA glycosyla
Externí odkaz:
https://doaj.org/article/d7f045b476d94cb59da2ab03aa3d7809
Autor:
Åslaug Helland, Hege G. Russnes, Gro Live Fagereng, Khalid Al-Shibli, Yvonne Andersson, Thomas Berg, Line Bjørge, Egil Blix, Bodil Bjerkehagen, Sigmund Brabrand, Marte Grønlie Cameron, Astrid Dalhaug, Dalia Dietzel, Tom Dønnem, Espen Enerly, Åsmund Flobak, Sverre Fluge, Bjørnar Gilje, Bjørn Tore Gjertsen, Bjørn Henning Grønberg, Kari Grønås, Tormod Guren, Hanne Hamre, Åse Haug, Daniel Heinrich, Geir Olav Hjortland, Eivind Hovig, Randi Hovland, Ann-Charlotte Iversen, Emiel Janssen, Jon Amund Kyte, Hedda von der Lippe Gythfeldt, Ragnhild Lothe, Jo-Åsmund Lund, Leonardo Meza-Zepeda, Monica Cheng Munthe-Kaas, Olav Toai Duc Nguyen, Pitt Niehusmann, Hilde Nilsen, Katarina Puco, Anne Hansen Ree, Tonje Bøyum Riste, Karin Semb, Eli Sihn Samdal Steinskog, Andreas Stensvold, Pål Suhrke, Øyvind Tennøe, Geir E. Tjønnfjord, Liv Jorunn Vassbotn, Eline Aas, Kristine Aasebø, Kjetil Tasken, Sigbjørn Smeland
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/d1675781ce0d4327ba7f57f4b202f48a
Autor:
Evandro F. Fang, Yujun Hou, Sofie Lautrup, Martin Borch Jensen, Beimeng Yang, Tanima SenGupta, Domenica Caponio, Rojyar Khezri, Tyler G. Demarest, Yahyah Aman, David Figueroa, Marya Morevati, Ho-Joon Lee, Hisaya Kato, Henok Kassahun, Jong-Hyuk Lee, Deborah Filippelli, Mustafa Nazir Okur, Aswin Mangerich, Deborah L. Croteau, Yoshiro Maezawa, Costas A. Lyssiotis, Jun Tao, Koutaro Yokote, Tor Erik Rusten, Mark P. Mattson, Heinrich Jasper, Hilde Nilsen, Vilhelm A. Bohr
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
The molecular mechanisms of mitochondrial dysfunction in the premature ageing Werner syndrome were elusive. Here the authors show that NAD+ depletion-induced impaired mitophagy contributes to this phenomenon, shedding light on potential therapeutics.
Externí odkaz:
https://doaj.org/article/6fb6a8ffdc81475a8623958277a66533