Supplementary Figure 4 from Inhibition of the Replication Stress Response Is a Synthetic Vulnerability in SCLC That Acts Synergistically in Combination with Cisplatin

Autor: Anton Berns, Lodewyk F. A. Wessels, Hilda de Vries, Miranda Cozijnsen, Jan van der Vliet, Marieke van de Ven, Natalie Proost, Nanne Aben, Ana Teresa Avelar, Remco Nagel

Supplementary figure 4. Cell viability data based to generate the synergy plots in Figures 2 and 3.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01456a994a6da6126e64204a68188bf0
https://doi.org/10.1158/1535-7163.22509532

Supplementary Figure 1C + D from Inhibition of the Replication Stress Response Is a Synthetic Vulnerability in SCLC That Acts Synergistically in Combination with Cisplatin

Autor: Anton Berns, Lodewyk F. A. Wessels, Hilda de Vries, Miranda Cozijnsen, Jan van der Vliet, Marieke van de Ven, Natalie Proost, Nanne Aben, Ana Teresa Avelar, Remco Nagel

Supplementary figure 1C. Sequencing tracks of a part of the Zwilch gene targered by a second unique sgRNA, with the wildtype sequence (top) and sgRNA treated sequence (bottom) shown. D. Tide analysis showing editing efficiency of the second Zwilch ta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f6fd98104475e560d4a7cde7f896998
https://doi.org/10.1158/1535-7163.22509541

Supplementary Figure 2 from Inhibition of the Replication Stress Response Is a Synthetic Vulnerability in SCLC That Acts Synergistically in Combination with Cisplatin

Autor: Anton Berns, Lodewyk F. A. Wessels, Hilda de Vries, Miranda Cozijnsen, Jan van der Vliet, Marieke van de Ven, Natalie Proost, Nanne Aben, Ana Teresa Avelar, Remco Nagel

Supplementary figure 2. Graphs showing the correlation between all three replicates of the genome�wide CRISPR�Cas9 screen at the start of the experiment (t=0) and at the final time point (t=14).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cc3314d2e626bd6d2dc47afc7a85e4a
https://doi.org/10.1158/1535-7163.22509538

Inhibition of the Replication Stress Response Is a Synthetic Vulnerability in SCLC That Acts Synergistically in Combination with Cisplatin

Autor: Anton Berns, Natalie Proost, Nanne Aben, Marieke van de Ven, Jan van der Vliet, Hilda de Vries, Remco Nagel, Lodewyk F. A. Wessels, Ana Teresa Avelar, Miranda Cozijnsen

Publikováno v: Molecular Cancer Therapeutics. 18:762-770

Small cell lung cancer (SCLC) is generally regarded as very difficult to treat, mostly due to the development of metastases early in the disease and a quick relapse with resistant disease. SCLC patients initially show a good response to treatment wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ac2ac0c43fb300d709142bfa91ac84e
https://doi.org/10.1158/1535-7163.mct-18-0972

Human malignant mesothelioma is recapitulated in immunocompetent BALB/c mice injected with murine AB cells

Autor: Hilda de Vries, Roberta Frapolli, Elena Gatti, Camilla Recordati, Michela Frenquelli, Maurizio D'Incalci, Marco Bianchi, Massimo Venturini, Antonello E. Spinelli, Francesco De Marchis, Luca Crippa, Renzo Boldorini, Eltjona Rrapaj, Rosanna Mezzapelle, Eugenio Scanziani, Claudio Doglioni, Massimo P. Crippa, Chiara Ceriotti, Laura Perani, Silvia Valtorta, Lorenza Pecciarini, Alessandro Preti, Rosa Maria Moresco, Anton Berns

Publikováno v: Scientific Reports
Scientific reports (Nature Publishing Group) 6 (2016): 22850. doi:10.1038/srep22850
info:cnr-pdr/source/autori:Mezzapelle R.; Rrapaj E.; Gatti E.; Ceriotti C.; De Marchis F.; Preti A.; Spinelli A.E.; Perani L.; Venturini M.; Valtorta S.; Moresco R.M.; Pecciarini L.; Doglioni C.; Frenquelli M.; Crippa L.; Recordati C.; Scanziani E.; De Vries H.; Berns A.; Frapolli R.; Boldorini R.; D'Incalci M.; Bianchi M.E.; Crippa M.P./titolo:Human malignant mesothelioma is recapitulated in immunocompetent BALB%2Fc mice injected with murine AB cells/doi:10.1038%2Fsrep22850/rivista:Scientific reports (Nature Publishing Group)/anno:2016/pagina_da:22850/pagina_a:/intervallo_pagine:22850/volume:6

Malignant Mesothelioma is a highly aggressive cancer, which is difficult to diagnose and treat. Here we describe the molecular, cellular and morphological characterization of a syngeneic system consisting of murine AB1, AB12 and AB22 mesothelioma cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4f0d217fdbf74b4817a5f3f99d5224a
http://hdl.handle.net/10281/117009