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pro vyhledávání: '"Hilda Morales-Alanis"'
Autor:
Lucien Nedelec, Jean Jacques, Hilda Morales-Alanis, Marie Josephe Brienne, Colette Tournemine, Vesperto Torelli, M.-M. Bouton
Publikováno v:
Journal of Medicinal Chemistry. 28:1796-1803
In the search for new antiandrogens, a number of des-A-steroids were prepared by condensation of Grignard reagents with lactone 3. From the resulting key intermediates 5, various structural modifications were performed such as the introduction of an